ANAPC2 and MEOX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ANAPC2	MEOX1
Description		anaphase promoting complex subunit 2	mesenchyme homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol Cullin-RING Ubiquitin Ligase Complex	Chromatin Nucleus Cytoplasm
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Nervous System Development Proteasomal Protein Catabolic Process Negative Regulation Of Gene Expression Protein Ubiquitination Cell Differentiation Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Synaptic Plasticity Positive Regulation Of Axon Extension Positive Regulation Of Dendrite Morphogenesis Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Synapse Maturation Protein Branched Polyubiquitination	Somite Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Differentiation Somite Development Sclerotome Development
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 32888494)	Fractures ( 30158200)
Interacting Genes		16 interacting genes: ANAPC11 ANAPC7 CDC20 CDC26 CDC27 FZR1 MAD2L1 MEOX1 PTTG1 SMAD2 SUMO2 UBC UBE2C UBE2D2 UFD1 WDR5	99 interacting genes: ACBD4 ACOT12 AIRIM ALOX5 ANAPC2 APP APPL1 ATG9A BANP BNIP2 BYSL C14orf119 C1orf50 CACNB3 CATSPERT CCDC102B CDC34 CIAO1 CIB3 CIMIP4 CKS1B CNOT11 CSNK2A1 CWF19L2 CYFIP1 DCX DNAAF19 DUSP3 EIF4A3 EIF4EBP1 EMD FMR1 GCC1 GEMIN2 GPANK1 GYS1 HMBOX1 HMGB3 HOMER3 HOXC8 HYCC2 INPP5J KANK2 KCTD7 L3MBTL2 LMNA MAPK9 MBD3 MCRS1 MEF2A MID1 MID2 MKRN3 MLX MORF4L1 MVP NAGK NDOR1 NEIL2 OSGIN1 PAGE3 PARVG PAX1 PAX3 PCP2 PDE4C PELI2 PIN1 PLCD4 PM20D2 POLR3GL PPM1F PRKAG1 PRKN QRICH1 RAD52 RANBP3 RBM41 RBM5 SDCBP SEC14L4 SOX10 SPAG8 SPIC SYT17 TCEANC TCP11L1 TRAPPC2L TRIM41 TRIML2 TRIP10 TXLNA TXNL4B UBE2R2 UBXN2B UBXN7 UNC45A ZCCHC10 ZNF410
Entrez ID		29882	4222
HPRD ID		07367	02537
Ensembl ID		ENSG00000176248	ENSG00000005102
Uniprot IDs		Q9UJX6	P50221
PDB IDs		4UI9 4YII 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6NXK 6OB1 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Protein K11-linked Ubiquitination Cell Division Post-translational Protein Modification Modification-dependent Protein Catabolic Process Regulation Of Meiotic Cell Cycle Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Sister Chromatid Segregation Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Ubiquitination Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Segregation Protein Branched Polyubiquitination Regulation Of Mitotic Sister Chromatid Separation Regulation Of Nuclear Division Positive Regulation Of Mitotic Sister Chromatid Separation Protein Polyubiquitination Proteasomal Protein Catabolic Process Macromolecule Catabolic Process Regulation Of Chromosome Separation Regulation Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Regulation Of Reproductive Process Positive Regulation Of Ubiquitin Protein Ligase Activity Nucleoplasm Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Chromosome Separation Protein Modification Process Protein Catabolic Process Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Organization Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Cell Cycle Phase Transition Nucleus Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Catabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Phase Transition Mitotic Checkpoint Complex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process	Protein Binding Cytosol Nucleoplasm Cytoplasm Growth Cone Filopodium Spindle Pole Centrosome Translation Repressor Activity Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Identical Protein Binding Perinuclear Region Of Cytoplasm Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Translation At Postsynapse
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