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ANAPC2 and UFD1L
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
ANAPC2
UFD1L
Gene Name
anaphase promoting complex subunit 2
ubiquitin fusion degradation 1 like (yeast)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Nucleus
Cytosol
Molecular Function
Ubiquitin Protein Ligase Binding
Ubiquitin-specific Protease Activity
Receptor Binding
Protein Binding
Protein Complex Binding
Biological Process
Mitotic Cell Cycle
Mitotic Nuclear Division
Mitotic Spindle Assembly Checkpoint
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Synaptic Plasticity
Positive Regulation Of Axon Extension
Positive Regulation Of Dendrite Morphogenesis
Cell Division
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Protein K11-linked Ubiquitination
Positive Regulation Of Synapse Maturation
Skeletal System Development
Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Phosphorylation of the APC/C
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Antigen processing: Ubiquitination & Proteasome degradation
Separation of Sister Chromatids
Inactivation of APC/C via direct inhibition of the APC/C complex
Cellular Senescence
Mitotic Anaphase
APC/C:Cdc20 mediated degradation of Securin
M Phase
Inactivation of APC/C via direct inhibition of the APC/C complex
Autodegradation of Cdh1 by Cdh1:APC/C
Mitotic Spindle Checkpoint
Class I MHC mediated antigen processing & presentation
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Senescence-Associated Secretory Phenotype (SASP)
Regulation of APC/C activators between G1/S and early anaphase
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Cell Cycle, Mitotic
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Regulation of mitotic cell cycle
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Cell Cycle Checkpoints
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Mitotic Metaphase and Anaphase
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
13 interactors:
ANAPC11
ANAPC5
ANAPC7
CDC20
CDC26
CDC27
FBXO5
FZR1
MAD2L1
SMAD2
UBE2C
UBE2S
UFD1L
19 interactors:
A2M
AMFR
ANAPC2
F13A1
GZMK
IGHM
MASP1
NEDD8
NGFR
NPLOC4
NUB1
PIK3CA
PPHLN1
SNX1
TAF1C
TIAM2
TP53
UBXN6
VCP
Entrez ID
29882
7353
HPRD ID
07367
06778
Ensembl ID
ENSG00000176248
ENSG00000070010
Uniprot IDs
B4DGH7
Q9UJX6
Q541A5
Q92890
PDB IDs
2YUJ
Enriched GO Terms of Interacting Partners
?
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Mitotic Sister Chromatid Separation
Protein K11-linked Ubiquitination
Negative Regulation Of Protein Ubiquitination
Regulation Of Protein Ubiquitination
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Mitotic Spindle Assembly Checkpoint
Negative Regulation Of Cellular Protein Catabolic Process
Spindle Assembly Checkpoint
Negative Regulation Of Cell Division
Regulation Of Chromosome Segregation
Mitotic Spindle Checkpoint
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Chromosome Segregation
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Mitotic Nuclear Division
Spindle Checkpoint
Negative Regulation Of Mitotic Nuclear Division
Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Mitotic Metaphase/anaphase Transition
Cellular Protein Catabolic Process
Negative Regulation Of Protein Catabolic Process
Protein Catabolic Process
Regulation Of Mitotic Nuclear Division
Cell Division
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Division
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Transferase Activity
Negative Regulation Of Chromosome Organization
Cellular Macromolecule Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Chromosome Organization
Positive Regulation Of Protein Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Protein Catabolic Process
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
ER-associated Ubiquitin-dependent Protein Catabolic Process
Protein Catabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Complement Activation
ER-nucleus Signaling Pathway
Response To Growth Factor
Regulation Of Fibroblast Apoptotic Process
Protein Modification By Small Protein Conjugation
Regulation Of Proteolysis
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Protein Catabolic Process
Protein Metabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Response To Endoplasmic Reticulum Stress
Blood Coagulation
Hemostasis
Regulation Of Complement Activation
Cellular Response To Organic Substance
Response To Organic Substance
Platelet Activation
Regulation Of Proteasomal Protein Catabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Response To Stress
Neurotrophin TRK Receptor Signaling Pathway
Vesicle-mediated Transport
Neurotrophin Signaling Pathway
Regulation Of Humoral Immune Response
Positive Regulation Of Lys63-specific Deubiquitinase Activity
Positive Regulation Of Protein K63-linked Deubiquitination
Regulation Of Body Fluid Levels
Protein Ubiquitination
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Wound Healing
Positive Regulation Of Cell Death
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
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