KCNK1 and ERGIC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNK1	ERGIC3
Description		potassium two pore domain channel subfamily K member 1	ERGIC and golgi 3
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Apical Plasma Membrane Dendrite Cytoplasmic Vesicle Brush Border Membrane Potassium Channel Complex Cell Projection Perikaryon Synapse Recycling Endosome Synaptic Membrane Inward Rectifier Potassium Channel Complex	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Retrograde Transporter Complex, Golgi To ER Transporter Complex
	Molecular Function	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Channel Activity Potassium Ion Leak Channel Activity Identical Protein Binding Protein Heterodimerization Activity Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Glutamate Secretion Monoatomic Ion Transmembrane Transport Response To Nicotine Sodium Ion Transmembrane Transport Regulation Of Resting Membrane Potential Regulation Of Postsynaptic Membrane Potential Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Chloride Transmembrane Transport	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Vesicle-mediated Transport Positive Regulation Of Intracellular Protein Transport
Pathways		Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Phase 4 - resting membrane potential
Drugs		Ibutilide Quinidine Quinidine barbiturate
Diseases
GWAS		Cognitive function ( 28808816) Diabetic retinopathy ( 21441570) Periodontal microbiota ( 22699663) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Apolipoprotein B levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 24097068 25961943 20686565) Height ( 28552196) Hip circumference adjusted for BMI ( 28552196 34021172) LDL cholesterol levels ( 32203549) Refractive error ( 32231278) Schizophrenia ( 28991256) Total cholesterol levels ( 28334899 30275531) Triglycerides ( 25961943) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: AQP6 CDIPT CREB3 CREB3L1 ERGIC3 KRTAP10-3 LMNA SENP1 STOM TCIRG1 TMEM139 TMEM14B UBE2I	233 interacting genes: ABHD16A ADGRE2 ADIPOQ AGPAT4 AGTRAP AIG1 ALG10 AOC2 APOC3 APOD APOL2 AQP10 AQP2 AQP3 ARLN ASGR1 ATP13A1 ATP1B4 ATP6V0C BCL2L1 BET1 BIK BNIP3 BTN2A2 BUD31 C14orf180 C2 C3orf52 CCDC167 CCR2 CCR4 CCR8 CD207 CD302 CD81 CDIPT CDS2 CEBPA CFHR5 CHRM4 CIAO2A CLCA4 CLDN19 CLDN8 CLDND2 CMTM5 CNIH1 CNIH3 COL4A5 COX20 CTSA CTXN3 CXorf66 CYB561 CYB561D2 CYB5B CYBC1 CYP4F2 DEFB103A DEFB103B EBP EMC6 EMP1 EMP3 ENTPD3 ERG28 ERGIC1 EXTL1 F2RL1 FA2H FAM3C FAXDC2 FETUB FIS1 FKBP8 FUNDC2 FXYD2 FXYD3 FXYD6 FXYD6-FXYD2 GAST GIMAP1 GIMAP5 GJB2 GOSR2 GPM6B GPR151 GPR152 GPR35 GPR37 GYPA HHATL HMOX1 HMOX2 IFITM3 IGFBP5 INSIG2 ITGAM JAGN1 KCNK1 LHFPL5 LPAR3 LPCAT2 MALL MARCHF2 MARCHF5 MFF MFSD6 MIP MS4A13 MYADM NDRG4 NDUFB6 NEU1 NINJ2 NKG7 NRG4 NRM NSG1 OGT ORMDL1 ORMDL2 ORMDL3 PAQR5 PAQR7 PEX11G PEX16 PGAP2 PLLP PLN PLP1 PLPP4 PMP22 PNLIPRP1 POMGNT1 RFT1 RHAG RTP2 RUSF1 SCARB2 SCD SEC22B SEC23A SELENOK SERP2 SFXN5 SLC13A3 SLC1A1 SLC29A2 SLC30A2 SLC35A1 SLC35A4 SLC35B2 SLC35B4 SLC38A7 SLC41A1 SLC41A2 SLC49A3 SMAGP SMCO4 SMIM1 SMIM3 SNCA SNORC SPN STATH STRIT1 STX12 STX1B STX3 STX8 SYNGR1 SYNJ2BP SYS1 TAP1 TECR TF THBD TM4SF4 TMEM100 TMEM107 TMEM109 TMEM11 TMEM120B TMEM128 TMEM140 TMEM141 TMEM147 TMEM14A TMEM14B TMEM179B TMEM203 TMEM218 TMEM222 TMEM229B TMEM243 TMEM254 TMEM42 TMEM60 TMEM65 TMEM86A TMEM86B TMEM97 TMUB2 TNFRSF10C TOMM6 TRAM1L1 TRARG1 TREX1 TRIM32 TSPAN33 TSPO2 UBIAD1 UNC50 UNC93B1 UPK1B VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VKORC1L1 VMP1 VSTM1 VTI1B YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZDHHC15 ZDHHC21 ZFPL1
Entrez ID		3775	51614
HPRD ID		03447	15306
Ensembl ID		ENSG00000135750	ENSG00000125991
Uniprot IDs		O00180	A2TJK5 Q9Y282
PDB IDs		3UKM
Enriched GO Terms of Interacting Partners?		Nitrate Transmembrane Transporter Activity Negative Regulation Of Apoptotic Signaling Pathway Transcription Coregulator Binding Presynaptic Cytosol Postsynaptic Cytosol Protein Sumoylation SUMO Conjugating Enzyme Activity Dentin Mineralization Response To Silver Ion CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deacetylase Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress PH-gated Chloride Channel Activity Nitrate Transmembrane Transport DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Memory T Cell Activation Alcohol Binding Endoplasmic Reticulum Unfolded Protein Response Retrograde Transporter Complex, Golgi To ER	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity SNARE Complex Plasma Membrane Establishment Of Protein Localization To Membrane Endomembrane System Vesicle Fusion Golgi Membrane Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport Localization Within Membrane Chemical Homeostasis Membrane Fusion Protein Localization To Membrane Membrane Organization SNARE Complex Assembly Protein Localization To Cell Periphery Establishment Of Protein Localization Establishment Of Protein Localization To Plasma Membrane Mitochondrial Outer Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Transmembrane Transport SNARE Binding Cellular Localization Membrane Docking Cholesterol Binding Bleb Assembly Structural Constituent Of Myelin Sheath Vesicle Organization Organelle Localization By Membrane Tethering Transport Vesicle Protein Localization To Plasma Membrane Intracellular Chemical Homeostasis Vesicle-mediated Transport To The Plasma Membrane Vesicle Docking Golgi Apparatus Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Homeostatic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Water Channel Activity Endosome To Plasma Membrane Protein Transport Golgi Vesicle Transport Mitochondrial Membrane Myelination Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
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