KCNK1 and TCIRG1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		KCNK1	TCIRG1
Description		potassium two pore domain channel subfamily K member 1	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Apical Plasma Membrane Dendrite Cytoplasmic Vesicle Brush Border Membrane Potassium Channel Complex Cell Projection Perikaryon Synapse Recycling Endosome Synaptic Membrane Inward Rectifier Potassium Channel Complex	Vacuolar Proton-transporting V-type ATPase, V0 Domain Nucleus Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Endosome Membrane Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Secretory Granule Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V0 Domain Phagocytic Vesicle Ficolin-1-rich Granule Membrane
	Molecular Function	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Channel Activity Potassium Ion Leak Channel Activity Identical Protein Binding Protein Heterodimerization Activity Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Glutamate Secretion Monoatomic Ion Transmembrane Transport Response To Nicotine Sodium Ion Transmembrane Transport Regulation Of Resting Membrane Potential Regulation Of Postsynaptic Membrane Potential Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Chloride Transmembrane Transport	Autophagosome Assembly Ossification Osteoclast Proliferation Monoatomic Ion Transport Intracellular Calcium Ion Homeostasis Autophagy Apoptotic Process Inflammatory Response Cellular Defense Response Vacuolar Acidification Protein Catabolic Process In The Vacuole Lysosomal Lumen Acidification Positive Regulation Of Cell Population Proliferation Regulation Of Proton Transport Response To Silver Ion Gene Expression Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Macroautophagy Optic Nerve Development Establishment Of Cell Polarity Myeloid Cell Differentiation B Cell Differentiation T Cell Differentiation Osteoclast Differentiation Ruffle Organization Protein Localization To Organelle Memory T Cell Activation T-helper 1 Cell Activation Odontogenesis T Cell Homeostasis Tooth Eruption Bone Resorption Regulation Of Osteoblast Differentiation PH Reduction Homeostasis Of Number Of Cells Regulation Of Insulin Secretion Intracellular PH Reduction Establishment Of Vesicle Localization Retina Development In Camera-type Eye Hematopoietic Stem Cell Homeostasis Enamel Mineralization Cellular Response To Cytokine Stimulus Phagosome Acidification Dentin Mineralization Proton Transmembrane Transport
Pathways		Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Phase 4 - resting membrane potential	ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Ibutilide Quinidine Quinidine barbiturate	Tiludronic acid
Diseases			Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Cognitive function ( 28808816) Diabetic retinopathy ( 21441570) Periodontal microbiota ( 22699663) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Heel bone mineral density ( 30598549) Reticulocyte count ( 32888494)
Interacting Genes		13 interacting genes: AQP6 CDIPT CREB3 CREB3L1 ERGIC3 KRTAP10-3 LMNA SENP1 STOM TCIRG1 TMEM139 TMEM14B UBE2I	6 interacting genes: CYTH2 KCNK1 MTDH POGZ TERF1 TLX3
Entrez ID		3775	10312
HPRD ID		03447	05207
Ensembl ID		ENSG00000135750	ENSG00000110719
Uniprot IDs		O00180	Q13488
PDB IDs		3UKM
Enriched GO Terms of Interacting Partners?		Nitrate Transmembrane Transporter Activity Negative Regulation Of Apoptotic Signaling Pathway Transcription Coregulator Binding Presynaptic Cytosol Postsynaptic Cytosol Protein Sumoylation SUMO Conjugating Enzyme Activity Dentin Mineralization Response To Silver Ion CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deacetylase Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress PH-gated Chloride Channel Activity Nitrate Transmembrane Transport DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Memory T Cell Activation Alcohol Binding Endoplasmic Reticulum Unfolded Protein Response Retrograde Transporter Complex, Golgi To ER	Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomere Lengthening Brush Border Membrane Apical Plasma Membrane CTP Binding Chromosome Organization DATP Binding Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly DNA Biosynthetic Process Telomere Maintenance Neurofibrillary Tangle Assembly UTP Binding Regulation Of DNA Biosynthetic Process Sulfonylurea Receptor Binding Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Rho GDP-dissociation Inhibitor Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Bicellular Tight Junction Telomere Organization Ligand-gated Channel Activity Neuron Migration Sperm Mitochondrial Sheath Inward Rectifier Potassium Channel Complex Fibrillar Center Inner Dynein Arm Telomerase Holoenzyme Complex Assembly Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Intercellular Canaliculus Chaperone-mediated Autophagy Positive Regulation Of Cardiac Muscle Contraction DNA Metabolic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of Protein-containing Complex Assembly Inclusion Body Assembly Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Potassium Channel Complex Regulation Of Establishment Of Protein Localization To Chromosome
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