KCNK1 and STOM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNK1	STOM
Description		potassium two pore domain channel subfamily K member 1	stomatin
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GO Annotations	Cellular Component	Endosome Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Apical Plasma Membrane Dendrite Cytoplasmic Vesicle Brush Border Membrane Potassium Channel Complex Cell Projection Perikaryon Synapse Recycling Endosome Synaptic Membrane Inward Rectifier Potassium Channel Complex	Extracellular Space Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Cytoskeleton Plasma Membrane Membrane Cytoplasmic Vesicle Vesicle Azurophil Granule Membrane Specific Granule Membrane Melanosome Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Membrane Blood Microparticle
	Molecular Function	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Channel Activity Potassium Ion Leak Channel Activity Identical Protein Binding Protein Heterodimerization Activity Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding Ion Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity RNA Polymerase Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Glutamate Secretion Monoatomic Ion Transmembrane Transport Response To Nicotine Sodium Ion Transmembrane Transport Regulation Of Resting Membrane Potential Regulation Of Postsynaptic Membrane Potential Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Chloride Transmembrane Transport	Regulation Of Monoatomic Ion Transmembrane Transport Host-mediated Activation Of Viral Genome Replication Positive Regulation Of Viral Process Positive Regulation Of Protein Targeting To Membrane
Pathways		Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Phase 4 - resting membrane potential	Stimuli-sensing channels Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle
Drugs		Ibutilide Quinidine Quinidine barbiturate
Diseases			Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP)
GWAS		Cognitive function ( 28808816) Diabetic retinopathy ( 21441570) Periodontal microbiota ( 22699663) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		13 interacting genes: AQP6 CDIPT CREB3 CREB3L1 ERGIC3 KRTAP10-3 LMNA SENP1 STOM TCIRG1 TMEM139 TMEM14B UBE2I	81 interacting genes: AIG1 APOA2 ASIC1 ASIC2 ASIC3 ATP1B3 ATP6V0B ATP6V0C BCL2L2 BNIP1 C2 C3orf52 CFHR5 CHST1 CLDN19 CLRN2 CMTM5 CNIH3 CTXN3 CYB5B CYB5R3 DAGLA DVL3 EMP1 ERG28 FAXDC2 FUNDC2 GIMAP1 GIMAP5 GPR25 GPR37L1 GRM2 HMOX2 KCNK1 KTN1 LANCL1 LNPEP MGLL MMP14 NKG7 ORMDL1 PEDS1-UBE2V1 PEMT PGA4 PMP22 PTCH1 RPL13A RPRM RTP2 RUVBL1 RUVBL2 SCD SELENOK SERP2 SFT2D1 SFT2D2 SFXN1 SFXN5 SLC2A1 SLC35B4 SMCO4 STX6 TECR THSD7B TMEM109 TMEM120B TMEM140 TMEM14B TMEM203 TMEM208 TMEM254 TMEM60 TMEM86B TMEM98 TMPO TNF TNFRSF10C TSPO2 VAMP4 WFDC2 YIPF6
Entrez ID		3775	2040
HPRD ID		03447	00585
Ensembl ID		ENSG00000135750	ENSG00000148175
Uniprot IDs		O00180	F8VSL7 P27105
PDB IDs		3UKM	7WH3
Enriched GO Terms of Interacting Partners?		Nitrate Transmembrane Transporter Activity Negative Regulation Of Apoptotic Signaling Pathway Transcription Coregulator Binding Presynaptic Cytosol Postsynaptic Cytosol Protein Sumoylation SUMO Conjugating Enzyme Activity Dentin Mineralization Response To Silver Ion CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deacetylase Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress PH-gated Chloride Channel Activity Nitrate Transmembrane Transport DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Memory T Cell Activation Alcohol Binding Endoplasmic Reticulum Unfolded Protein Response Retrograde Transporter Complex, Golgi To ER	Membrane Endoplasmic Reticulum Membrane Sensory Perception Of Sour Taste Endoplasmic Reticulum Response To Acidic PH Sodium Channel Activity PH-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity Ligand-gated Sodium Channel Activity Protein Binding Cellular Response To Type II Interferon Response To PH PH-gated Monoatomic Ion Channel Activity Nitric-oxide Synthase Complex Synaptic Vesicle To Endosome Fusion Mitochondrial Outer Membrane Response To Type II Interferon Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Nitrite Reductase (NO-forming) Activity R2TP Complex Cellular Response To PH Detection Of Mechanical Stimulus Involved In Sensory Perception Acylglycerol Catabolic Process Diacylglycerol Catabolic Process Lipid Biosynthetic Process Amino Acid Transport Organic Anion Transport Telomerase RNA Localization To Cajal Body Sensory Perception Of Taste Response To Mechanical Stimulus Plasma Membrane
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