OLA1 and PRMT5

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		OLA1	PRMT5
Gene Name		Obg-like ATPase 1	protein arginine methyltransferase 5
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Centrosome Membrane Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Methylosome
	Molecular Function	Protein Binding ATP Binding GTP Binding ATPase Activity Ribosome Binding Ribosomal Large Subunit Binding Metal Ion Binding	Core Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Ribonucleoprotein Complex Binding
	Biological Process		Negative Regulation Of Transcription From RNA Polymerase II Promoter Spliceosomal SnRNP Assembly Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Cell Proliferation Gene Expression Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Circadian Regulation Of Gene Expression NcRNA Metabolic Process Peptidyl-arginine N-methylation Endothelial Cell Activation Histone H4-R3 Methylation
Pathways			Chromatin modifying enzymes snRNP Assembly Chromatin organization Metabolism of non-coding RNA RMTs methylate histone arginines
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ASCC2 BARD1 BRCA1 HMGA1 PRMT5 TUBG1	67 interactors: ARGLU1 CALU CAPN1 CCAR2 CDYL2 CLK1 CLK3 CLNS1A COPRS CTDP1 DIO3 DNMT3A EZH2 FAM76B GRHL3 GTPBP2 H3F3C HIST1H3A HIST1H4A HIST2H2AC HOXC4 ING5 JAK1 JAK2 JAK3 LDHAL6B LENG8 LUC7L MAGEB2 MBP MCRS1 MEF2D MYOD1 MYOG NELFCD NUDCD2 OLA1 PHYHIP PRPF38A RBM23 RSRP1 SF3A3 SIN3A SLU7 SMARCA2 SMARCB1 SMARCC1 SMARCE1 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SSTR1 SUPT5H TRIB3 TYK2 WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZNF2 ZNF224 ZNF436 ZUFSP
Entrez ID		29789	10419
HPRD ID		15194	04955
Ensembl ID		ENSG00000138430	ENSG00000100462
Uniprot IDs		Q9NTK5	O14744
PDB IDs		2OHF	4GQB
Enriched GO Terms of Interacting Partners?		Protein K6-linked Ubiquitination Negative Regulation Of Gene Expression Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation DNA Repair Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Negative Regulation Of MRNA 3'-end Processing Oncogene-induced Cell Senescence Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Senescence-associated Heterochromatin Focus Assembly Protein Polyubiquitination Cellular Response To DNA Damage Stimulus Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Senescence Regulation Of Cell Cycle Regulation Of Gene Expression, Epigenetic Cellular Response To Indole-3-methanol Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Centriole Replication Cell Cycle Process DNA Metabolic Process Negative Regulation Of Protein Export From Nucleus Dosage Compensation By Inactivation Of X Chromosome Negative Regulation Of Chromatin Silencing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Establishment Of Integrated Proviral Latency Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription DNA Replication Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cell Aging Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Cellular Nitrogen Compound Metabolic Process Establishment Of Viral Latency Regulation Of Centriole Replication Histone H4-R3 Methylation Heterochromatin Assembly Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process Meiotic Spindle Organization	Gene Expression RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Organization Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Chromatin Modification Regulation Of RNA Metabolic Process MRNA Processing Nitrogen Compound Metabolic Process Regulation Of Gene Expression Chromosome Organization Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated MRNA Metabolic Process RNA Splicing RNA Biosynthetic Process RNA Processing Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of Transcription, DNA-templated MRNA Splicing, Via Spliceosome Regulation Of Nucleic Acid-templated Transcription RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly Positive Regulation Of Gene Expression Cellular Macromolecular Complex Assembly Histone Modification Positive Regulation Of Macromolecule Biosynthetic Process Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Ribonucleoprotein Complex Biogenesis Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-tyrosine Autophosphorylation Peptidyl-amino Acid Modification Positive Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Chromatin Remodeling Regulation Of Metabolic Process Positive Regulation Of Viral Transcription Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Nucleosome Disassembly Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		1b acetate antioxidant biomarker comparative discovered dosing glatiramer highlighted ifnbeta ikbke insufficiency integrated knowledgebases mediators ms naive nd6 neuropathy nrf2 optic plausible pleiotropic preservation reduces relapsing remitting sclerosis signatures	acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase
Tagcloud (Difference) ?		1b acetate antioxidant biomarker comparative discovered dosing glatiramer highlighted ifnbeta ikbke insufficiency integrated knowledgebases mediators ms naive nd6 neuropathy nrf2 optic plausible pleiotropic preservation reduces relapsing remitting sclerosis signatures	acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase
Tagcloud (Intersection) ?