BRF1 and RBL1

Number of citations of the paper that reports this interaction (PMID 10330166)
17

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		BRF1	RBL1
Gene Name		BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit	retinoblastoma-like 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Transcription Factor TFIIIB Complex Nucleoplasm	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	Zinc Ion Binding TBP-class Protein Binding	Protein Binding Transcription Factor Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase III Promoter Transcription Initiation From RNA Polymerase III Promoter RRNA Transcription TRNA Transcription Gene Expression Regulation Of MRNA Stability	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Viral Process Chromatin Modification Regulation Of Lipid Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle
Pathways		RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 2 Promoter	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419)
Protein-Protein Interactions		13 interactors: APP CSNK2A1 DTNBP1 GTF3C3 GTF3C4 GTF3C5 PCBD2 POLR3F RB1 RBL1 RBL2 TBP TP53	51 interactors: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB PLSCR1 PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 SUV420H2 TAF1 TOP1 USP4
Entrez ID		2972	5933
HPRD ID		05361	00312
Ensembl ID		ENSG00000185024	ENSG00000080839
Uniprot IDs		Q92994	P28749
PDB IDs			1H28
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase III Promoter RRNA Transcription 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter TRNA Transcription Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Biosynthetic Process Macromolecule Biosynthetic Process Neuron Apoptotic Process Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Neuron Death Positive Regulation Of Gene Expression Regulation Of Cell Cycle Phase Transition Glial Cell Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Chromatin Organization Mitotic Cell Cycle Positive Regulation Of Transcription, DNA-templated Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Checkpoint Regulation Of RNA Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of Metabolic Process Neuron Maturation Chromosome Organization Regulation Of Chromosome Organization Viral Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation	Transcription From RNA Polymerase II Promoter Cell Cycle Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Cell Cycle Process Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Multicellular Organismal Development
Tagcloud ?		5s alcohol cjun colony consumption decreases deregulation downregulate enhances eralpha iii indicates inhibits jun occupancy pol promoters reduces repress repressing repression rrna tam tamoxifen transcription translational trnas uncover upregulate	accounts adenocarcinoma applicable assist deaths diagnostics e2f6 effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr screen silico sub suitable suv39h1 tf tfdp1 transcriptomics vital worldwide
Tagcloud (Difference) ?		5s alcohol cjun colony consumption decreases deregulation downregulate enhances eralpha iii indicates inhibits jun occupancy pol promoters reduces repress repressing repression rrna tam tamoxifen transcription translational trnas uncover upregulate	accounts adenocarcinoma applicable assist deaths diagnostics e2f6 effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr screen silico sub suitable suv39h1 tf tfdp1 transcriptomics vital worldwide
Tagcloud (Intersection) ?