BRF1 and GTF3C4

Number of citations of the paper that reports this interaction (PubMedID 10523658)
54

Data Source:
HPRD (in vitro, in vivo)

		BRF1	GTF3C4
Description		BRF1 general transcription factor IIIB subunit	general transcription factor IIIC subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Transcription Factor TFIIIB Complex Nucleus Nucleoplasm Transcription Preinitiation Complex	Transcription Factor TFIIIC Complex Nucleus Nucleoplasm Mitochondrion
	Molecular Function	RNA Polymerase III General Transcription Initiation Factor Activity RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Protein Binding Zinc Ion Binding TBP-class Protein Binding Metal Ion Binding	RNA Polymerase III General Transcription Initiation Factor Activity DNA Binding Histone Acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Histone H3K14 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity
	Biological Process	DNA-templated Transcription Initiation Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter RRNA Transcription TRNA Transcription Transcription Preinitiation Complex Assembly	Chromatin Remodeling Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter 5S Class RRNA Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III
Pathways		RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter	RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS		Huntington's disease progression ( 28642124) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 22139419 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 27863252 29403010 32888494) Platelet distribution width ( 27863252) Red blood cell count ( 32888494)
Interacting Genes		16 interacting genes: APP CSNK2A1 DTNBP1 GTF3C3 GTF3C4 GTF3C5 PCBD2 POLR3F RB1 RBL1 RBL2 RHOU RLIM TBP TP53 UBC	13 interacting genes: AURKA BRCA1 BRF1 ETS2 GTF3C1 GTF3C2 GTF3C5 H3-4 H3C15 POLR3C POLR3F SUMO2 TBP
Entrez ID		2972	9329
HPRD ID		05361	11998
Ensembl ID		ENSG00000185024	ENSG00000125484
Uniprot IDs		Q92994 V9HVY2	B3KNH2 Q9UKN8
PDB IDs			8CLI 8CLJ 8CLL
Enriched GO Terms of Interacting Partners?		Transcription By RNA Polymerase III RNA Polymerase III General Transcription Initiation Factor Activity Regulation Of Lipid Kinase Activity RRNA Transcription Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III DNA-templated Transcription TRNA Transcription By RNA Polymerase III TRNA Transcription Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Chromatin Organization Nucleobase-containing Compound Biosynthetic Process Glial Cell Apoptotic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Transcription Initiation At RNA Polymerase III Promoter Regulation Of Cell Cycle G1/S Phase Transition DNA Binding Negative Regulation Of Gene Expression Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Promoter-specific Chromatin Binding DNA-templated Transcription Initiation Nucleus Transcription Regulator Complex RRNA Metabolic Process Regulation Of Mitotic Cell Cycle Epigenetic Regulation Of Gene Expression Regulation Of DNA-templated Transcription Negative Regulation Of Glial Cell Proliferation Regulation Of RNA Biosynthetic Process Core Promoter Sequence-specific DNA Binding Regulation Of Phosphorus Metabolic Process PML Body Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Molecular Function Activator Activity Chromatin Remodeling Regulation Of Cell Cycle Disordered Domain Specific Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Receptor Internalization	Transcription By RNA Polymerase III RNA Polymerase III General Transcription Initiation Factor Activity TRNA Transcription RRNA Transcription Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter DNA-templated Transcription Nucleoplasm TRNA Transcription By RNA Polymerase III DNA-templated Transcription Initiation DNA Binding Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process Protein-DNA Complex Assembly Pronucleus TRNA Metabolic Process Nucleus RRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process RNA Polymerase III Complex Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase III DNA-directed RNA Polymerase Activity Nucleobase-containing Compound Metabolic Process DNA-directed RNA Polymerase Complex Positive Regulation Of Interferon-beta Production Centrosome Cycle Condensed Nuclear Chromosome Male Germ Cell Nucleus Regulation Of Centrosome Cycle Regulation Of Interferon-beta Production Transcription Preinitiation Complex Assembly Histone H2AK127 Ubiquitin Ligase Activity Chromatin Remodeling Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Ectodermal Cell Fate Commitment Ubiquitin Protein Ligase Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Organizing Center Organization Structural Constituent Of Chromatin Transcription Factor TFIIIB Complex Protein Heterodimerization Activity Positive Regulation Of Oocyte Maturation RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding Positive Regulation Of Type I Interferon Production BRCA1-B Complex
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