GTF3A and OPTN

Number of citations of the paper that reports this interaction (PMID 10756201)
9

Data Source:
HPRD (in vitro)

		GTF3A	OPTN
Gene Name		general transcription factor IIIA	optineurin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagic Vacuole Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Membrane-bounded Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	DNA Binding RNA Binding Metal Ion Binding	Protein Binding Protein C-terminus Binding Rab GTPase Binding Polyubiquitin Binding K63-linked Polyubiquitin Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase III Promoter RRNA Transcription Gene Expression	Protein Targeting To Golgi G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Golgi Organization Signal Transduction Cell Death Macroautophagy Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response To Gram-negative Bacterium Golgi Ribbon Formation
Pathways		RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation	G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Body mass index ( 20935630)	Paget's disease ( 21623375 20436471)
Protein-Protein Interactions		4 interactors: CHMP5 GTF3C2 OPTN SCYL2	36 interactors: CALM1 CCDC53 CDC23 CYLD DAZAP2 EPS15 FAM178A FLII FOS GNAS GRM1 GTF3A HACE1 HTT MAP1LC3A MPP1 MYO6 PIAS4 RAB10 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RNF11 SQSTM1 TBC1D15 TBC1D17 TBK1 TNIP1 UBC UQCRQ ZNF329 ZNF398 ZNF670
Entrez ID		2971	10133
HPRD ID		02916	03891
Ensembl ID		ENSG00000122034	ENSG00000123240
Uniprot IDs		Q92664	Q96CV9
PDB IDs			2LO4 2LUE 3VTV 3VTW
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor Recycling Endosome To Lysosome Transport Lysosomal Transport Vacuolar Transport Cytoplasmic Transport Endosomal Transport Receptor Internalization Involved In Canonical Wnt Signaling Pathway Negative Regulation Of Receptor Recycling 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter Positive Regulation Of Clathrin-mediated Endocytosis Intracellular Transport TRNA Transcription Golgi Ribbon Formation Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Regulation Of Clathrin-mediated Endocytosis Establishment Of Localization In Cell Regulation Of Mitotic Spindle Organization Cell Separation After Cytokinesis Positive Regulation Of Receptor Internalization Protein Targeting To Golgi RRNA Transcription Golgi To Plasma Membrane Protein Transport Cellular Localization Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Mitotic Metaphase Plate Congression Mitotic Cell Cycle Process Regulation Of Receptor Internalization Metaphase Plate Congression Mitotic Cell Cycle Golgi To Plasma Membrane Transport Defense Response To Gram-negative Bacterium Positive Regulation Of Receptor-mediated Endocytosis Protein Localization To Golgi Apparatus Regulation Of Centrosome Duplication Receptor Internalization Establishment Of Chromosome Localization Membrane Organization Regulation Of Signaling Regulation Of Centrosome Cycle Transcription From RNA Polymerase III Promoter Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Lysosome Organization Intra-Golgi Vesicle-mediated Transport Macroautophagy Cell Cycle Process Negative Regulation Of Signal Transduction Mitotic Sister Chromatid Segregation	Endosomal Transport Rab Protein Signal Transduction Membrane Organization Ras Protein Signal Transduction Secretion By Cell Establishment Of Localization In Cell Intracellular Transport Intracellular Signal Transduction Secretion Protein Secretion Cellular Localization Cell Communication Signal Transduction Regulation Of Signaling Protein Transport Vesicle-mediated Transport Signaling Establishment Of Protein Localization Exocytosis Protein Localization Pattern Recognition Receptor Signaling Pathway Cellular Response To Stimulus Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Intracellular Protein Transport Positive Regulation Of Metabolic Process Positive Regulation Of Innate Immune Response Establishment Of Organelle Localization Establishment Of Vesicle Localization Vesicle Localization Cellular Protein Catabolic Process Regulation Of Vesicle-mediated Transport Melanosome Transport Regulation Of Intracellular Signal Transduction Pigment Granule Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor Signaling Pathway Establishment Of Melanosome Localization Protein Catabolic Process Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Organelle Localization Melanosome Localization Endomembrane System Organization Golgi Vesicle Transport Negative Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction
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Tagcloud (Difference) ?			advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto
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