GSTM1 and MAP3K5

Number of citations of the paper that reports this interaction (PMID 11278289)
57

Data Source:
HPRD (in vitro, in vivo)

		GSTM1	MAP3K5
Gene Name		glutathione S-transferase mu 1	mitogen-activated protein kinase kinase kinase 5
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Endoplasmic Reticulum Cytosol Protein Kinase Complex
	Molecular Function	Glutathione Transferase Activity Enzyme Binding Protein Homodimerization Activity Glutathione Binding	Magnesium Ion Binding Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Kinase Binding Protein Phosphatase Binding Protein Homodimerization Activity
	Biological Process	Glutathione Metabolic Process Xenobiotic Metabolic Process Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Small Molecule Metabolic Process Cellular Detoxification Of Nitrogen Compound Glutathione Derivative Biosynthetic Process	MAPK Cascade Activation Of MAPKK Activity Response To Ischemia Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process JNK Cascade Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Viral Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of Neuron Death Cellular Response To Reactive Nitrogen Species
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Oxidative Stress Induced Senescence Cellular Senescence
Drugs		Glutathione (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene Zinc Trihydroxide Glutathione S-(2,4 Dinitrobenzene) Fluorotryptophane (9s,10s)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene
Diseases
GWAS		Bladder cancer ( 20972438)
Protein-Protein Interactions		3 interactors: GSTM2 GSTM3 MAP3K5	50 interactors: AKT1 AKT2 ARRB1 ARRB2 CDC25A CDKN1A CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 GADD45B GEMIN5 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L PDCD6 PPP3R1 PPP5C PTPN11 QARS RAF1 SFN TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TXN USP9X YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		2944	4217
HPRD ID		00707	03904
Ensembl ID		ENSG00000134184	ENSG00000197442
Uniprot IDs		P09488	Q99683
PDB IDs		1GTU 1XW6 1XWK 1YJ6 2F3M	2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE
Enriched GO Terms of Interacting Partners?		Cellular Detoxification Of Nitrogen Compound Nitrobenzene Metabolic Process Detoxification Of Nitrogen Compound Xenobiotic Catabolic Process Glutathione Derivative Biosynthetic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Peptide Metabolic Process Response To Toxic Substance Cellular Response To Stress Cellular Modified Amino Acid Metabolic Process Cellular Amide Metabolic Process Sulfur Compound Metabolic Process Establishment Of Blood-nerve Barrier Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Skeletal Muscle Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Caffeine Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Cation Channel Activity Relaxation Of Muscle Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Reactive Nitrogen Species Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Stress Response To Caffeine Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Response To Organic Cyclic Compound Positive Regulation Of Cation Channel Activity Response To Ischemia Activation Of JUN Kinase Activity Cellular Response To Alkaloid Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Programmed Necrotic Cell Death Endothelial Cell Development Necrotic Cell Death Negative Regulation Of Ion Transmembrane Transport Positive Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Transmembrane Transport Positive Regulation Of Transporter Activity Cellular Response To Hydrogen Peroxide Regulation Of Calcium Ion Transmembrane Transporter Activity	Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Apoptotic Process Positive Regulation Of Transferase Activity Programmed Cell Death Positive Regulation Of Protein Modification Process Regulation Of Stress-activated MAPK Cascade Cell Death Death Regulation Of MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Response To Stress Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Regulation Of Apoptotic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of JNK Cascade Positive Regulation Of Metabolic Process Cellular Response To Stimulus Response To Stimulus Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Programmed Cell Death Signal Transduction Signaling Positive Regulation Of Cell Death
Tagcloud ?		ab associations bcc bccs comprised cyp2d6 cytochrome em genotypes glutathione gstt1 heterogeneity lesion mpp null numbers p450 phenotype presentation presentations reflect reflects spp subgroup subgroups transferase truncal unidentified uv	199a2 angptl2 awry chondrosarcoma cmet discovering dnm3 evenly fibrosarcoma flt1 flt4 foxl1 genetics gli1 hif1alpha hmga2 kdr liposarcoma mdk med12 muc4 mycn osteocytes pcsk1 relentless sarcoma tek tie1 yeats4
Tagcloud (Difference) ?		ab associations bcc bccs comprised cyp2d6 cytochrome em genotypes glutathione gstt1 heterogeneity lesion mpp null numbers p450 phenotype presentation presentations reflect reflects spp subgroup subgroups transferase truncal unidentified uv	199a2 angptl2 awry chondrosarcoma cmet discovering dnm3 evenly fibrosarcoma flt1 flt4 foxl1 genetics gli1 hif1alpha hmga2 kdr liposarcoma mdk med12 muc4 mycn osteocytes pcsk1 relentless sarcoma tek tie1 yeats4
Tagcloud (Intersection) ?