GSTM1 and MAP3K5

Number of citations of the paper that reports this interaction (PubMedID 11278289)
0

Data Source:
HPRD (in vivo, in vitro)

		GSTM1	MAP3K5
Description		glutathione S-transferase mu 1	mitogen-activated protein kinase kinase kinase 5
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Endoplasmic Reticulum Cytosol External Side Of Plasma Membrane Protein-containing Complex Protein Kinase Complex IRE1-TRAF2-ASK1 Complex
	Molecular Function	Glutathione Transferase Activity Transferase Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Lipid Metabolic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Hepoxilin Biosynthetic Process Cellular Detoxification Of Nitrogen Compound Glutathione Derivative Biosynthetic Process	MAPK Cascade Immune System Process Response To Ischemia Apoptotic Process JNK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress P38MAPK Cascade Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Neuron Apoptotic Process Stress-activated MAPK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Endothelial Cell Apoptotic Process Cellular Senescence Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of P38MAPK Cascade Cellular Response To Reactive Nitrogen Species Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Glutathione conjugation Azathioprine ADME Paracetamol ADME	Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence
Drugs		Glutathione Chloroquine (9R,10R)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene Zinc trihydroxide S-(2,4-dinitrophenyl)glutathione Glutathione disulfide 5-fluorotryptophan Deoxycholic acid (9S,10S)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Bladder cancer ( 20972438) Blood protein levels ( 30072576) Liver enzyme levels (alanine transaminase) ( 33972514) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Platelet count ( 32888494)	Eosinophil count ( 32888494) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: GSTM2 GSTM3 MAP3K5	69 interacting genes: AKT1 ARRB2 AURKA BIRC2 CCND2 CDC25A CDC25C CDK4 CDK6 CDKN1A CDKN2A CIB1 CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 FGFR4 FZR1 GADD45B GEMIN5 GLIS2 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L NF2 PDCD6 PPP3R1 PPP5C PRMT1 PTPN11 QARS1 RAF1 SFN SIAH1 STK11 TEAD2 TERT TNFAIP3 TNFAIP8L1 TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TULP3 TXN UBE2I USP9X YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		2944	4217
HPRD ID		00707	03904
Ensembl ID		ENSG00000134184	ENSG00000197442
Uniprot IDs		P09488 X5D932 X5DR03	A0A8V8TMH5 Q99683
PDB IDs		1GTU 1XW6 1XWK 1YJ6 2F3M 7BEU 8VOU	2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE 5ULM 5UOR 5UOX 5UP3 5V19 5V24 5VIL 5VIO 6E2M 6E2N 6E2O 6EJL 6OYT 6OYW 6VRE 6XIH 7MU6 7MU7 8QGY
Enriched GO Terms of Interacting Partners?		Nitrobenzene Metabolic Process Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound Glutathione Binding Benzene-containing Compound Metabolic Process Glutathione Transferase Activity Xenobiotic Catabolic Process Glutathione Metabolic Process Protein Homodimerization Activity Xenobiotic Metabolic Process Cellular Detoxification Modified Amino Acid Metabolic Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Establishment Of Blood-nerve Barrier Protein Kinase Complex Sulfur Compound Metabolic Process IRE1-TRAF2-ASK1 Complex Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Transferase Activity Hepoxilin Biosynthetic Process Identical Protein Binding Sperm Fibrous Sheath Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Enzyme Binding JUN Kinase Kinase Kinase Activity Cellular Response To Caffeine Endothelial Cell Apoptotic Process Cellular Response To Purine-containing Compound Relaxation Of Cardiac Muscle Calcium Channel Inhibitor Activity Response To Caffeine Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Reactive Nitrogen Species Regulation Of Skeletal Muscle Contraction Relaxation Of Muscle Linoleic Acid Metabolic Process Glutathione Peroxidase Activity Programmed Necrotic Cell Death Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress MAP Kinase Kinase Kinase Activity Stress-activated MAPK Cascade Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Stress-activated Protein Kinase Signaling Cascade P38MAPK Cascade Positive Regulation Of P38MAPK Cascade Fatty Acid Binding Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Alkaloid Long-chain Fatty Acid Biosynthetic Process	Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of MAPK Cascade Signal Transduction Cytosol Cytoplasm Positive Regulation Of MAPK Cascade Cellular Response To Stress Regulation Of Protein Metabolic Process MAPK Cascade Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Regulation Of Apoptotic Process Protein Kinase Binding Protein Modification Process Positive Regulation Of Protein Metabolic Process Transferase Activity Enzyme Binding Regulation Of Primary Metabolic Process Protein Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Positive Regulation Of Metabolic Process Protein Serine Kinase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Regulation Of JNK Cascade Kinase Activity Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Catalytic Activity Identical Protein Binding Negative Regulation Of Signal Transduction Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Protein Metabolic Process Regulation Of Innate Immune Response
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