GSTM1 and GSTM3

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		GSTM1	GSTM3
Gene Name		glutathione S-transferase mu 1	glutathione S-transferase mu 3 (brain)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Sperm Fibrous Sheath Extracellular Vesicular Exosome
	Molecular Function	Glutathione Transferase Activity Enzyme Binding Protein Homodimerization Activity Glutathione Binding	Glutathione Transferase Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding
	Biological Process	Glutathione Metabolic Process Xenobiotic Metabolic Process Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Small Molecule Metabolic Process Cellular Detoxification Of Nitrogen Compound Glutathione Derivative Biosynthetic Process	Glutathione Metabolic Process Xenobiotic Metabolic Process Establishment Of Blood-nerve Barrier Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Response To Estrogen Small Molecule Metabolic Process Cellular Detoxification Of Nitrogen Compound Glutathione Derivative Biosynthetic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Glutathione (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene Zinc Trihydroxide Glutathione S-(2,4 Dinitrobenzene) Fluorotryptophane (9s,10s)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene	Glutathione
Diseases
GWAS		Bladder cancer ( 20972438)
Protein-Protein Interactions		3 interactors: GSTM2 GSTM3 MAP3K5	6 interactors: GSTM1 GSTM2 GSTM4 GSTM5 SH3GL2 UCHL5
Entrez ID		2944	2947
HPRD ID		00707	00712
Ensembl ID		ENSG00000134184	ENSG00000134202
Uniprot IDs		P09488	P21266 Q6FGJ9
PDB IDs		1GTU 1XW6 1XWK 1YJ6 2F3M	3GTU
Enriched GO Terms of Interacting Partners?		Cellular Detoxification Of Nitrogen Compound Nitrobenzene Metabolic Process Detoxification Of Nitrogen Compound Xenobiotic Catabolic Process Glutathione Derivative Biosynthetic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Peptide Metabolic Process Response To Toxic Substance Cellular Response To Stress Cellular Modified Amino Acid Metabolic Process Cellular Amide Metabolic Process Sulfur Compound Metabolic Process Establishment Of Blood-nerve Barrier Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Skeletal Muscle Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Caffeine Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Cation Channel Activity Relaxation Of Muscle Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Reactive Nitrogen Species Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Stress Response To Caffeine Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Response To Organic Cyclic Compound Positive Regulation Of Cation Channel Activity Response To Ischemia Activation Of JUN Kinase Activity Cellular Response To Alkaloid Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Programmed Necrotic Cell Death Endothelial Cell Development Necrotic Cell Death Negative Regulation Of Ion Transmembrane Transport Positive Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Transmembrane Transport Positive Regulation Of Transporter Activity Cellular Response To Hydrogen Peroxide Regulation Of Calcium Ion Transmembrane Transporter Activity	Glutathione Derivative Biosynthetic Process Nitrobenzene Metabolic Process Glutathione Metabolic Process Xenobiotic Catabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Peptide Metabolic Process Cellular Detoxification Of Nitrogen Compound Cellular Modified Amino Acid Metabolic Process Cellular Amide Metabolic Process Detoxification Of Nitrogen Compound Sulfur Compound Metabolic Process Catabolic Process Cellular Response To Stimulus Response To Toxic Substance Small Molecule Metabolic Process Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Response To Stimulus Biosynthetic Process Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Nitrogen Compound Metabolic Process Regulation Of Skeletal Muscle Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Caffeine Nitrogen Compound Metabolic Process Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Cellular Response To Stress Negative Regulation Of Cation Channel Activity Forebrain Morphogenesis Relaxation Of Muscle Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Lateral Ventricle Development Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Caffeine Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Receptor Internalization Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Positive Regulation Of Cation Channel Activity Response To Growth Factor Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Cellular Response To Alkaloid Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Brain Morphogenesis
Tagcloud ?		ab associations bcc bccs comprised cyp2d6 cytochrome em genotypes glutathione gstt1 heterogeneity lesion mpp null numbers p450 phenotype presentation presentations reflect reflects spp subgroup subgroups transferase truncal unidentified uv	5r acquire bax clonogenic exact facilitation fractionated hcc hepatoma immunoblotting irradiation lymphocytic modality p27 parental pivotal plc prf radiation radioresistance radioresistant radiosensitivity radiotherapy reversing rt sensitized sensitizing transferase
Tagcloud (Difference) ?		ab associations bcc bccs comprised cyp2d6 cytochrome em genotypes glutathione gstt1 heterogeneity lesion mpp null numbers p450 phenotype presentation presentations reflect reflects spp subgroup subgroups truncal unidentified uv	5r acquire bax clonogenic exact facilitation fractionated hcc hepatoma immunoblotting irradiation lymphocytic modality p27 parental pivotal plc prf radiation radioresistance radioresistant radiosensitivity radiotherapy reversing rt sensitized sensitizing
Tagcloud (Intersection) ?		transferase