GSTM1

Description		glutathione S-transferase mu 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Glutathione Transferase Activity Transferase Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding
	Biological Process	Lipid Metabolic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Hepoxilin Biosynthetic Process Cellular Detoxification Of Nitrogen Compound Glutathione Derivative Biosynthetic Process
Pathways		Glutathione conjugation Azathioprine ADME Paracetamol ADME
Drugs		Glutathione Chloroquine (9R,10R)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene Zinc trihydroxide S-(2,4-dinitrophenyl)glutathione Glutathione disulfide 5-fluorotryptophan Deoxycholic acid (9S,10S)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Bladder cancer ( 20972438) Blood protein levels ( 30072576) Liver enzyme levels (alanine transaminase) ( 33972514) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Platelet count ( 32888494)
Interacting Genes		3 interacting genes: GSTM2 GSTM3 MAP3K5
Entrez ID		2944
HPRD ID		00707
Ensembl ID		ENSG00000134184
Uniprot IDs		P09488 X5D932 X5DR03
PDB IDs		1GTU 1XW6 1XWK 1YJ6 2F3M 7BEU 8VOU
Enriched GO Terms of Interacting Partners?		Nitrobenzene Metabolic Process Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound Glutathione Binding Benzene-containing Compound Metabolic Process Glutathione Transferase Activity Xenobiotic Catabolic Process Glutathione Metabolic Process Protein Homodimerization Activity Xenobiotic Metabolic Process Cellular Detoxification Modified Amino Acid Metabolic Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Establishment Of Blood-nerve Barrier Protein Kinase Complex Sulfur Compound Metabolic Process IRE1-TRAF2-ASK1 Complex Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Transferase Activity Hepoxilin Biosynthetic Process Identical Protein Binding Sperm Fibrous Sheath Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Enzyme Binding JUN Kinase Kinase Kinase Activity Cellular Response To Caffeine Endothelial Cell Apoptotic Process Cellular Response To Purine-containing Compound Relaxation Of Cardiac Muscle Calcium Channel Inhibitor Activity Response To Caffeine Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Reactive Nitrogen Species Regulation Of Skeletal Muscle Contraction Relaxation Of Muscle Linoleic Acid Metabolic Process Glutathione Peroxidase Activity Programmed Necrotic Cell Death Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress MAP Kinase Kinase Kinase Activity Stress-activated MAPK Cascade Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Stress-activated Protein Kinase Signaling Cascade P38MAPK Cascade Positive Regulation Of P38MAPK Cascade Fatty Acid Binding Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Alkaloid Long-chain Fatty Acid Biosynthetic Process
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