GSTM1

Gene Name		glutathione S-transferase mu 1
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Glutathione Transferase Activity Enzyme Binding Protein Homodimerization Activity Glutathione Binding
	Biological Process	Glutathione Metabolic Process Xenobiotic Metabolic Process Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Small Molecule Metabolic Process Cellular Detoxification Of Nitrogen Compound Glutathione Derivative Biosynthetic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Glutathione (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene Zinc Trihydroxide Glutathione S-(2,4 Dinitrobenzene) Fluorotryptophane (9s,10s)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene
Diseases
GWAS		Bladder cancer ( 20972438)
Protein-protein Interactions		3 interactors: GSTM2 GSTM3 MAP3K5
Entrez ID		2944
HPRD ID		00707
Ensembl ID		ENSG00000134184
Uniprot IDs		P09488
PDB IDs		1GTU 1XW6 1XWK 1YJ6 2F3M
Enriched GO Terms of Interacting Partners?		Cellular Detoxification Of Nitrogen Compound Nitrobenzene Metabolic Process Detoxification Of Nitrogen Compound Xenobiotic Catabolic Process Glutathione Derivative Biosynthetic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Peptide Metabolic Process Response To Toxic Substance Cellular Response To Stress Cellular Modified Amino Acid Metabolic Process Cellular Amide Metabolic Process Sulfur Compound Metabolic Process Establishment Of Blood-nerve Barrier Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Skeletal Muscle Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Caffeine Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Cation Channel Activity Relaxation Of Muscle Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Reactive Nitrogen Species Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Stress Response To Caffeine Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Response To Organic Cyclic Compound Positive Regulation Of Cation Channel Activity Response To Ischemia Activation Of JUN Kinase Activity Cellular Response To Alkaloid Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Programmed Necrotic Cell Death Endothelial Cell Development Necrotic Cell Death Negative Regulation Of Ion Transmembrane Transport Positive Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Transmembrane Transport Positive Regulation Of Transporter Activity Cellular Response To Hydrogen Peroxide Regulation Of Calcium Ion Transmembrane Transporter Activity
Tagcloud ?		ab associations bcc bccs comprised cyp2d6 cytochrome em genotypes glutathione gstt1 heterogeneity lesion mpp null numbers p450 phenotype presentation presentations reflect reflects spp subgroup subgroups transferase truncal unidentified uv