GSTM1 and GSTM2

Number of citations of the paper that reports this interaction (PMID 6500576)
15

Data Source:
HPRD (in vitro)

		GSTM1	GSTM2
Gene Name		glutathione S-transferase mu 1	glutathione S-transferase mu 2 (muscle)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Cytosol Sarcoplasmic Reticulum Extracellular Vesicular Exosome
	Molecular Function	Glutathione Transferase Activity Enzyme Binding Protein Homodimerization Activity Glutathione Binding	Glutathione Transferase Activity Receptor Binding Enzyme Binding Protein Homodimerization Activity Glutathione Binding
	Biological Process	Glutathione Metabolic Process Xenobiotic Metabolic Process Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Small Molecule Metabolic Process Cellular Detoxification Of Nitrogen Compound Glutathione Derivative Biosynthetic Process	Glutathione Metabolic Process Xenobiotic Metabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Small Molecule Metabolic Process Relaxation Of Cardiac Muscle Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Detoxification Of Nitrogen Compound Cellular Response To Caffeine Glutathione Derivative Biosynthetic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Glutathione (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene Zinc Trihydroxide Glutathione S-(2,4 Dinitrobenzene) Fluorotryptophane (9s,10s)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene	Glutathione Glutathione S-(2,4 Dinitrobenzene) Oxidized Glutathione Disulfide S-METHYL-GLUTATHIONE
Diseases
GWAS		Bladder cancer ( 20972438)
Protein-Protein Interactions		3 interactors: GSTM2 GSTM3 MAP3K5	2 interactors: GSTM1 GSTM3
Entrez ID		2944	2946
HPRD ID		00707	00710
Ensembl ID		ENSG00000134184	ENSG00000213366
Uniprot IDs		P09488	P28161 Q0D2I8
PDB IDs		1GTU 1XW6 1XWK 1YJ6 2F3M	1HNA 1HNB 1HNC 1XW5 1YKC 2AB6 2C4J 2GTU 3GTU 3GUR
Enriched GO Terms of Interacting Partners?		Cellular Detoxification Of Nitrogen Compound Nitrobenzene Metabolic Process Detoxification Of Nitrogen Compound Xenobiotic Catabolic Process Glutathione Derivative Biosynthetic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Peptide Metabolic Process Response To Toxic Substance Cellular Response To Stress Cellular Modified Amino Acid Metabolic Process Cellular Amide Metabolic Process Sulfur Compound Metabolic Process Establishment Of Blood-nerve Barrier Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Skeletal Muscle Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Caffeine Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Cation Channel Activity Relaxation Of Muscle Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Reactive Nitrogen Species Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Stress Response To Caffeine Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Response To Organic Cyclic Compound Positive Regulation Of Cation Channel Activity Response To Ischemia Activation Of JUN Kinase Activity Cellular Response To Alkaloid Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Programmed Necrotic Cell Death Endothelial Cell Development Necrotic Cell Death Negative Regulation Of Ion Transmembrane Transport Positive Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Transmembrane Transport Positive Regulation Of Transporter Activity Cellular Response To Hydrogen Peroxide Regulation Of Calcium Ion Transmembrane Transporter Activity	Cellular Detoxification Of Nitrogen Compound Nitrobenzene Metabolic Process Detoxification Of Nitrogen Compound Xenobiotic Catabolic Process Glutathione Derivative Biosynthetic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Peptide Metabolic Process Response To Toxic Substance Cellular Modified Amino Acid Metabolic Process Cellular Amide Metabolic Process Sulfur Compound Metabolic Process Establishment Of Blood-nerve Barrier Endothelial Cell Development Cellular Response To Stress Catabolic Process Endothelial Cell Differentiation Endothelium Development Peripheral Nervous System Development Small Molecule Metabolic Process Epithelial Cell Development Response To Estrogen Response To Stress
Tagcloud ?		ab associations bcc bccs comprised cyp2d6 cytochrome em genotypes glutathione gstt1 heterogeneity lesion mpp null numbers p450 phenotype presentation presentations reflect reflects spp subgroup subgroups transferase truncal unidentified uv	ankrd1 ccl13 ccl3l3 ccl7 ccl9 csda dbq1 egr3 gadd45g herpud1 hsp90aa hspa1a hspd1 hsph1 mgst3 mybpc3 myh7 myom2 nfkbid nppa opioidergic ptgds saa1 sarcomeric selp serpina3 serpinh1 slp xirp1
Tagcloud (Difference) ?		ab associations bcc bccs comprised cyp2d6 cytochrome em genotypes glutathione gstt1 heterogeneity lesion mpp null numbers p450 phenotype presentation presentations reflect reflects spp subgroup subgroups transferase truncal unidentified uv	ankrd1 ccl13 ccl3l3 ccl7 ccl9 csda dbq1 egr3 gadd45g herpud1 hsp90aa hspa1a hspd1 hsph1 mgst3 mybpc3 myh7 myom2 nfkbid nppa opioidergic ptgds saa1 sarcomeric selp serpina3 serpinh1 slp xirp1
Tagcloud (Intersection) ?