GSTM1 and GSTM2

Number of citations: 49 (PubMedID 12192076)
Data Source: HPRD (in vitro)

		GSTM1	GSTM2
Name		glutathione S-transferase mu 1	glutathione S-transferase mu 2
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Cytosol Sarcoplasmic Reticulum Extracellular Exosome
	Molecular Function	Glutathione Transferase Activity Transferase Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding	Glutathione Transferase Activity Glutathione Peroxidase Activity Fatty Acid Binding Protein Binding Transferase Activity Calcium Channel Inhibitor Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding Transmembrane Transporter Binding
	Biological Process	Lipid Metabolic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Hepoxilin Biosynthetic Process Cellular Detoxification Of Nitrogen Compound Glutathione Derivative Biosynthetic Process	Lipid Metabolic Process Glutathione Metabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Linoleic Acid Metabolic Process Hepoxilin Biosynthetic Process Relaxation Of Cardiac Muscle Cellular Detoxification Of Nitrogen Compound Cellular Response To Caffeine Cellular Oxidant Detoxification
Pathways		Glutathione conjugation Azathioprine ADME Paracetamol ADME	Glutathione conjugation
Drugs		Glutathione Chloroquine (9R,10R)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene Zinc trihydroxide S-(2,4-dinitrophenyl)glutathione Glutathione disulfide 5-fluorotryptophan Deoxycholic acid (9S,10S)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene	Glutathione S-(2,4-dinitrophenyl)glutathione Glutathione disulfide Glutathione disulfide Deoxycholic acid S-Methyl glutathione
GWAS		Alanine aminotransferase levels ( 34315874 ) Aspartate aminotransferase levels ( 34315874 ) Bladder cancer ( 20972438 ) Blood protein levels ( 30072576 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Mean platelet volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 32888494 ) Platelet count ( 32888494 )	Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) HDL cholesterol levels ( 32203549 ) LDL cholesterol levels ( 32203549 ) Metabolite levels ( 31628463 ) Urinary metabolite levels in chronic kidney disease ( 31959995 )
Interacting Genes		3 interacting genes: GSTM2 GSTM3 MAP3K5	3 interacting genes: GSTM1 GSTM3 PTEN
Entrez ID		2944	2946
HPRD ID		00707	00710
Ensembl ID		ENSG00000134184	ENSG00000213366
Uniprot IDs		P09488 X5D932 X5DR03	P28161 Q0D2I8
PDB IDs		1GTU 1XW6 1XWK 1YJ6 2F3M 7BEU 8VOU	1HNA 1HNB 1HNC 1XW5 1YKC 2AB6 2C4J 2GTU 3GTU 3GUR 5HWL
GO Terms Enriched among Interactors		Nitrobenzene Metabolic Process Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound Glutathione Binding Benzene-containing Compound Metabolic Process Glutathione Transferase Activity Xenobiotic Catabolic Process Glutathione Metabolic Process Protein Homodimerization Activity Xenobiotic Metabolic Process Cellular Detoxification Modified Amino Acid Metabolic Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Establishment Of Blood-nerve Barrier Protein Kinase Complex Sulfur Compound Metabolic Process IRE1-TRAF2-ASK1 Complex Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Transferase Activity Hepoxilin Biosynthetic Process Identical Protein Binding Sperm Fibrous Sheath Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Enzyme Binding JUN Kinase Kinase Kinase Activity Cellular Response To Caffeine Endothelial Cell Apoptotic Process Cellular Response To Purine-containing Compound Relaxation Of Cardiac Muscle Calcium Channel Inhibitor Activity Response To Caffeine Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Reactive Nitrogen Species Regulation Of Skeletal Muscle Contraction Relaxation Of Muscle Linoleic Acid Metabolic Process Glutathione Peroxidase Activity Programmed Necrotic Cell Death Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress MAP Kinase Kinase Kinase Activity Stress-activated MAPK Cascade Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Stress-activated Protein Kinase Signaling Cascade P38MAPK Cascade Positive Regulation Of P38MAPK Cascade Fatty Acid Binding Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Alkaloid Long-chain Fatty Acid Biosynthetic Process	Nitrobenzene Metabolic Process Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound Glutathione Binding Benzene-containing Compound Metabolic Process Glutathione Transferase Activity Xenobiotic Catabolic Process Enzyme Binding Glutathione Metabolic Process Xenobiotic Metabolic Process Cellular Detoxification Negative Regulation Of Synaptic Vesicle Clustering Modified Amino Acid Metabolic Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Establishment Of Blood-nerve Barrier Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Sulfur Compound Metabolic Process Glutathione Derivative Biosynthetic Process Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Identical Protein Binding Hepoxilin Biosynthetic Process Sperm Fibrous Sheath Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Density Assembly Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Anaphase-promoting Complex Binding Forebrain Morphogenesis Presynaptic Membrane Assembly Presynaptic Membrane Organization Postsynaptic Specialization Assembly Schmidt-Lanterman Incisure Negative Regulation Of Excitatory Postsynaptic Potential Locomotor Rhythm Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Maternal Behavior Phosphatidylinositol-3-phosphate Phosphatase Activity Prepulse Inhibition Meiotic Spindle Assembly Myelin Maintenance