GSN and ACTB

Number of citations of the paper that reports this interaction (PubMedID 10945978)
0

Data Source:
HPRD (in vivo)

		GSN	ACTB
Description		gelsolin	actin beta
Image
GO Annotations	Cellular Component	Podosome Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Sarcoplasm Lamellipodium Actin Cap Cortical Actin Cytoskeleton Secretory Granule Lumen Phagocytic Vesicle Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Kinetochore Chromatin Nucleosome Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Brush Border Cell-cell Junction Adherens Junction Focal Adhesion Actin Cytoskeleton Membrane Nuclear Matrix SWI/SNF Complex RSC-type Complex Lamellipodium Axon Cortical Cytoskeleton Vesicle Protein-containing Complex Brahma Complex NuA4 Histone Acetyltransferase Complex Cytoplasmic Ribonucleoprotein Granule Apical Junction Complex Calyx Of Held Synapse Extracellular Exosome Tight Junction NpBAF Complex NBAF Complex Blood Microparticle Dense Body Schaffer Collateral - CA1 Synapse Presynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse BBAF Complex GBAF Complex Ribonucleoprotein Complex
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol 3-kinase Catalytic Subunit Binding Myosin II Binding Metal Ion Binding Actin Filament Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Kinesin Binding Protein Kinase Binding Nitric-oxide Synthase Regulator Activity Tat Protein Binding Nucleosomal DNA Binding Identical Protein Binding Tau Protein Binding Nitric-oxide Synthase Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Transporter Regulator Activity
	Biological Process	Phagocytosis, Engulfment Actin Filament Organization Central Nervous System Development Actin Polymerization Or Depolymerization Positive Regulation Of Gene Expression Striated Muscle Atrophy Vesicle-mediated Transport Extracellular Matrix Disassembly Cell Projection Organization Cell Projection Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Actin Filament Depolymerization Protein Destabilization Response To Muscle Stretch Positive Regulation Of Apoptotic Process Host-mediated Suppression Of Symbiont Invasion Actin Filament Severing Barbed-end Actin Filament Capping Positive Regulation Of Actin Nucleation Actin Filament Capping Relaxation Of Cardiac Muscle Cilium Assembly Cellular Response To Type II Interferon Regulation Of Podosome Assembly Cardiac Muscle Cell Contraction Renal Protein Absorption Hepatocyte Apoptotic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Establishment Of T Cell Polarity Regulation Of Plasma Membrane Raft Polarization Regulation Of Receptor Clustering Positive Regulation Of Protein Processing In Phagocytic Vesicle Amyloid Fibril Formation	Morphogenesis Of A Polarized Epithelium Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Axonogenesis Positive Regulation Of Cell Population Proliferation Substantia Nigra Development Regulation Of Mitotic Metaphase/anaphase Transition Adherens Junction Assembly Maintenance Of Blood-brain Barrier Regulation Of Apoptotic Process Apical Protein Localization Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Cell Motility Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Regulation Of Cell Cycle Regulation Of G0 To G1 Transition Platelet Aggregation Protein Localization To Adherens Junction Cellular Response To Cytochalasin B Postsynaptic Actin Cytoskeleton Organization Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Stem Cell Population Maintenance Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Neutrophil degranulation Sensory processing of sound by outer hair cells of the cochlea Amyloid fiber formation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation HATs acetylate histones Prefoldin mediated transfer of substrate to CCT/TriC Folding of actin by CCT/TriC EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions B-WICH complex positively regulates rRNA expression RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation UCH proteinases DNA Damage Recognition in GG-NER Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOF GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Regulation of CDH1 Function Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs		Zinc Latrunculin A Copper Zinc acetate	Quercetin Phenethyl Isothiocyanate
Diseases		Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome Familial amyloidosis	Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Blood protein levels ( 30072576)	Global electrical heterogeneity phenotypes ( 29622589) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Relative hand skill in reading disability ( 24068947) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		28 interacting genes: ACTA1 ACTB ACTG1 ACTN4 APP AR BCAR1 CASP3 CEBPA CLIC5 CSK ERBB2 FHIT FN1 HSP90AA1 LIMK2 PDE4B PIK3CG PLCG1 PTK2B PXN STK39 TNIK TOM1L1 VASP VCL VDAC1 WEE2-AS1	161 interacting genes: A2M ABLIM1 ABRA ACD ACTC1 ACTG1 ALOX5 ANXA7 AQP2 AR ARPC1B ATF7IP BBS4 BCL2L1 CAP1 CAPZA1 CCN2 CCT2 CCT4 CCT5 CCT8 CDC37 CDK5R2 CDKN1A CDKN2A CFL1 CFL2 CLIC4 CLIC6 CLNS1A CNN2 CORO1A CORO7 COTL1 CPNE1 CPNE2 CPNE4 CREBBP CSNK1A1 CSNK2B DMTN DNASE1 DSCR9 DSTN DUSP19 DYNLL1 EEF1A1 EHHADH EMD ERG EZR FABP4 FHL3 FLII FXR1 GAPDH GNA12 GSN H2AX HCK HIP1R HMMR HNRNPAB HNRNPD HNRNPU HSD17B4 HSPB2 HTR6 KHDRBS1 LASP1 LCOR LGALS13 LINC01554 LINC02582 LMNA LMOD1 LRRK2 LYN MAP1B MAP2 MAPT MRGBP MTNR1A MX1 MYO18B MYO1E MYOC NCALD NCF1 NDEL1 NEBL NOS2 NRAP NSMAF NT5E NTAQ1 OGT P2RX7 PCYT1A PDIA2 PDLIM5 PFDN1 PFDN4 PFN1 PFN2 PHACTR4 PLD1 PLD2 PLG POLR2A POT1 PRKCD PROSER2 PTN PTPRF RAB4A RAC1 RAC2 RCC1 RPL10A S100A11 SAMHD1 SCN10A SHBG SMAD3 SMAD9 SMARCA4 SMN1 SPTAN1 SPTB SPTBN2 SRPK2 SSH1 SSH2 SSH3 STX4 SUMO2 SYNJ2BP TANC1 TGM2 TINF2 TK1 TMSB4X TMSB4XP1 TMSB4XP4 TNNI2 TPM1 TPM2 TPM3 TRIM15 TSHR TTR UBC UBE2I UBE3A VHL VSNL1 WASF1 WASF2 WASF3 XPO6
Entrez ID		2934	60
HPRD ID		00674	00032
Ensembl ID		ENSG00000148180	ENSG00000075624
Uniprot IDs		A0A0A0MS51 A0A0A0MT01 A0A384MEF1 A0A8V8TND7 B7Z4U6 P06396	P60709 Q1KLZ0
PDB IDs		1C0F 1C0G 1D4X 1DEJ 1EQY 1ESV 1H1V 1KCQ 1MDU 1NLV 1NM1 1NMD 1P8X 1P8Z 1SOL 1T44 1YAG 1YVN 2FF3 2FF6 2FH1 2FH2 2FH3 2FH4 3A5L 3A5M 3A5N 3A5O 3CI5 3CIP 3CJB 3CJC 3FFK 3FFN 3TU5 4PKG 4PKH 4PKI 4S10 4Z94 5FAE 5FAF 5H3M 5H3N 5O2Z 5UBO 5ZZ0 6H1F 6JCO 6JEG 6JEH 6LJE 6LJF 6Q9R 6Q9Z 6QBF 6QW3 7P2B 8VIZ 8VKH	3BYH 3D2U 3J82 3LUE 6ANU 6ICT 6ICV 6LTJ 6MBJ 6MBK 6MBL 6NBW 6OX0 6OX1 6OX2 6OX3 6OX4 6OX5 6V62 6V63 6WK1 6WK2 7AS4 7P1H 7QJ6 7QJ9 7VDV 7W28 7W29 7Y8R 7ZTC 7ZTD 8COG 8DNH 8IB8 8OI8 8OID 8QR1 8RTT 8RTY 8RU2 8RX1 8UAU 8VRD 8VRJ 8VRK 8X15 8X19 8X1C 8XVG 8XVT 9B2Z 9C57 9C62 9C6N 9FJM
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Regulation Of Monoatomic Cation Transmembrane Transport Lamellipodium Actin Cytoskeleton Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Locomotion Multicellular Organismal-level Homeostasis Regulation Of Metal Ion Transport Regulation Of Cellular Component Organization Regulation Of Immune System Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Apoptotic Process Nucleotide Binding Regulation Of Monoatomic Ion Transport Regulation Of Cell Migration Regulation Of Programmed Cell Death Focal Adhesion Extracellular Exosome Positive Regulation Of Immune System Process Anatomical Structure Homeostasis Tissue Homeostasis Regulation Of Cell Adhesion Regulation Of Cell Motility Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytosol Regulation Of Transport Regulation Of Locomotion Platelet Aggregation Plasma Membrane Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process ATP Binding Regulation Of Calcium Ion Transport Actin Cytoskeleton Organization Signal Transduction Transmembrane Transporter Binding Positive Regulation Of Gene Expression Identical Protein Binding Homotypic Cell-cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Actin Filament-based Process Cytoplasm Positive Regulation Of Protein Metabolic Process Cell Motility ERBB Signaling Pathway Cell Body Protein Kinase Binding Positive Regulation Of MAPK Cascade	Actin Binding Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Organelle Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Negative Regulation Of Supramolecular Fiber Organization Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Actin Filament-based Process Actin Filament Binding Regulation Of Cellular Component Organization Regulation Of Cellular Component Size Actin Filament Organization Negative Regulation Of Cytoskeleton Organization Cytoskeleton Negative Regulation Of Actin Filament Polymerization Cytoplasm Negative Regulation Of Cellular Component Organization Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Organelle Organization Actin Cytoskeleton Regulation Of Biological Quality Negative Regulation Of Protein-containing Complex Assembly Extracellular Exosome Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Cortical Actin Cytoskeleton Regulation Of Actin Filament Depolymerization Actin Filament Organelle Organization Glutamatergic Synapse Positive Regulation Of Cellular Component Organization Modification Of Postsynaptic Actin Cytoskeleton Cytosol Regulation Of Protein Localization Regulation Of Protein Depolymerization Negative Regulation Of Actin Filament Depolymerization Focal Adhesion Regulation Of Telomere Maintenance Via Telomerase Modification Of Postsynaptic Structure Actin Filament Capping Postsynapse Modification Of Synaptic Structure Regulation Of Cellular Localization
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