GSN and ACTN4

Number of citations of the paper that reports this interaction (PMID 11733011)
3

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		GSN	ACTN4
Gene Name		gelsolin	actinin, alpha 4
Image
Gene Ontology Annotations	Cellular Component	Ruffle Extracellular Region Cytosol Focal Adhesion Actin Cytoskeleton Lamellipodium Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cell-cell Junction Focal Adhesion Z Disc Ribonucleoprotein Complex Cortical Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Neuron Projection Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding	Nucleoside Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Poly(A) RNA Binding Protein N-terminus Binding Actin Filament Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Aging Oligodendrocyte Development Vesicle-mediated Transport Actin Filament Polymerization Regulation Of Cell Adhesion Tissue Regeneration Actin Nucleation Response To Ethanol Phosphatidylinositol-mediated Signaling Actin Filament Severing Barbed-end Actin Filament Capping Response To Folic Acid Cilium Morphogenesis Cellular Response To Cadmium Ion	Response To Hypoxia Platelet Degranulation Blood Coagulation Protein Transport Platelet Activation Positive Regulation Of Sodium:proton Antiporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Pinocytosis Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Tight Junction Assembly Protein Localization To Tight Junction Regulation Of Nucleic Acid-templated Transcription
Pathways		Amyloids Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins	Response to elevated platelet cytosolic Ca2+ Nephrin interactions Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Heart rate ( 23583979)
Protein-Protein Interactions		23 interactors: ACTA1 ACTB ACTG1 ACTN4 APP AR BCAR1 CASP3 CLIC5 CSK FHIT FN1 LIMK2 PIK3CG PLCG1 PTK2B PXN STK39 TNIK TOM1L1 VASP VCL VDAC1	43 interactors: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 ESR1 GSN HDAC7 INO80 ITGB1 KPNA2 LRRC7 MAGI1 MAPK7 MEF2A MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTPN11 PTPN6 RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 STAT1 TJP1 TRIM3 TXN UCHL5 USP6NL VDR
Entrez ID		2934	81
HPRD ID		00674	05222
Ensembl ID		ENSG00000148180
Uniprot IDs		B7Z4U6 B7Z5V1 F5H1A8 P06396	O43707
PDB IDs		1C0F 1C0G 1D4X 1DEJ 1EQY 1ESV 1H1V 1KCQ 1MDU 1NLV 1NM1 1NMD 1P8X 1P8Z 1SOL 1T44 1YAG 1YVN 2FF3 2FF6 2FH1 2FH2 2FH3 2FH4 3A5L 3A5M 3A5N 3A5O 3CI5 3CIP 3CJB 3CJC 3FFK 3FFN 3TU5	1WLX 1YDI 2R0O
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Cell Junction Assembly Response To Wounding Regulation Of Body Fluid Levels Wound Healing Adherens Junction Organization Movement Of Cell Or Subcellular Component Cell Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Cell-cell Junction Organization Response To Stimulus Response To Stress Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Cell Morphogenesis Regulation Of Kinase Activity Cell Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cell Differentiation Cellular Component Assembly Cell Projection Organization Signaling Anatomical Structure Development Generation Of Neurons Platelet Aggregation Cell Communication Positive Regulation Of Protein Metabolic Process Locomotion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Kinase Activity Signal Transduction Positive Regulation Of Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Nervous System Development Developmental Process Multicellular Organismal Development Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neuron Differentiation System Development Regulation Of Cellular Component Organization Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity	Cellular Response To Organic Substance Response To Organic Substance Negative Regulation Of Signaling Response To Stress Developmental Process Cellular Response To Interferon-gamma Response To Interferon-gamma Negative Regulation Of Signal Transduction Regulation Of Cell Death Response To Abiotic Stimulus Defense Response Cellular Response To Lipid Regulation Of Signaling Regulation Of Apoptotic Process Signal Transduction Interferon-gamma-mediated Signaling Pathway Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Component Assembly Signaling Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cell Communication Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Innate Immune Response Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Lipid Multicellular Organismal Development Response To Stimulus Regulation Of Cellular Component Organization Regulation Of Cellular Process Response To Hormone Abortive Mitotic Cell Cycle System Development Mitotic Cell Cycle Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide
Tagcloud ?		amyloidogenic amyloidosis autosomal contractility counter crossbreeding dermatological disturbed dominantly folding furin g2 g654a gelsolin generates hampered hereditary inherited mt1 nanobodies nanobody nb11 ophthalmological proteases proteolysis proteolytic rendering secreting shield	1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Difference) ?		amyloidogenic amyloidosis autosomal contractility counter crossbreeding dermatological disturbed dominantly folding furin g2 g654a gelsolin generates hampered hereditary inherited mt1 nanobodies nanobody nb11 ophthalmological proteases proteolysis proteolytic rendering secreting shield	1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Intersection) ?