PDIA3 and TAP1

Number of citations of the paper that reports this interaction (PubMedID 9545232)
66

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		PDIA3	TAP1
Description		protein disulfide isomerase family A member 3	transporter 1, ATP binding cassette subfamily B member
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Focal Adhesion Cell Surface Melanosome MHC Class I Peptide Loading Complex Phagocytic Vesicle Recycling Endosome Membrane Tapasin-ERp57 Complex Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Phagocytic Vesicle Membrane Organelle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Centriolar Satellite MHC Class I Peptide Loading Complex TAP Complex
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Isomerase Activity Identical Protein Binding LncRNA Binding	Nucleotide Binding Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity ATP Hydrolysis Activity MHC Class Ib Protein Binding MHC Protein Binding MHC Class I Protein Binding Peptide Antigen Binding Protein Homodimerization Activity ADP Binding Metal Ion Binding TAP1 Binding TAP2 Binding ABC-type Transporter Activity Peptide Transmembrane Transporter Activity
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class I Protein Complex Protein Folding Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Platelet Aggregation Extrinsic Apoptotic Signaling Pathway Cellular Response To Interleukin-7 Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class I Protein Complex Defense Response Protein Transport Peptide Transport Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Transmembrane Transport
Pathways		ER-Phagosome pathway ER-Phagosome pathway Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type1
GWAS		Blood protein levels ( 30072576) Lead levels ( 26025379) Liver volume ( 34128465) Triglyceride levels ( 32203549)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Metabolite levels ( 23823483) Nephropathy ( 21399633)
Interacting Genes		25 interacting genes: APP BACE1 CALR CANX CEBPA CFTR ERO1A ERP27 ESR1 GYPC HLA-A IFNG LINC01554 MDM2 MTNR1B OGT PCAT1 PCBP2 RBFOX2 SLC12A3 SLC2A1 STAT3 SUMO4 TAP1 UBE3A	27 interacting genes: AQP6 CHRM3 CREB3 ERGIC3 ERVFRD-1 ESR1 GEMIN4 GPR152 HLA-F HLA-G KRTAP4-12 LCE2C LMNA MDFI MUL1 PDIA3 PSMB5 PSMB8 RNF19B SLC10A1 SLC10A6 SLC35H1 SSMEM1 TAP2 TAPBP TDP2 TMEM14B
Entrez ID		2923	6890
HPRD ID		03625	01359
Ensembl ID		ENSG00000167004	ENSG00000168394
Uniprot IDs		P30101 V9HVY3	A0A0S2Z5A6 B7Z7P4 Q03518 X5CKB3
PDB IDs		2ALB 2DMM 2H8L 3F8U 6ENY 7QNG 7QPD	1JJ7 5U1D 8T46 8T4E 8T4F 8T4G 8T4H 8T4I 8T4J
Enriched GO Terms of Interacting Partners?		MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Chemical Homeostasis Protein Folding In Endoplasmic Reticulum Regulation Of Glycolytic Process Intracellular Receptor Signaling Pathway Homeostatic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of ATP Metabolic Process Cellular Homeostasis Endoplasmic Reticulum Lumen Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Response To Hormone Response To Stress Negative Regulation Of RNA Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Intracellular Signal Transduction Amyloid Fibril Formation Lumenal Side Of Endoplasmic Reticulum Membrane Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Protein-containing Complex Response To Ketone Positive Regulation Of ATP Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Proteolysis Response To Lipid Presynapse Response To Endoplasmic Reticulum Stress Positive Regulation Of Nitric Oxide Metabolic Process Enzyme Binding Regulation Of Generation Of Precursor Metabolites And Energy Organ Growth Regulation Of Protein Localization Cellular Response To Manganese Ion Hormone-mediated Signaling Pathway Monoatomic Cation Homeostasis Endoplasmic Reticulum Prostate Gland Growth L-ascorbic Acid Metabolic Process Monoatomic Ion Homeostasis Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Endocytosis Positive Regulation Of Interleukin-1 Beta Production Regulation Of Endocytosis	TAP1 Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen MHC Class I Peptide Loading Complex Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Peptide Antigen Assembly With MHC Class I Protein Complex Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Tapasin-ERp57 Complex Antigen Processing And Presentation Of Peptide Antigen TAP2 Binding Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Positive Regulation Of T Cell Mediated Cytotoxicity Bile Acid:sodium Symporter Activity Regulation Of T Cell Mediated Cytotoxicity MHC Class I Protein Complex Positive Regulation Of Natural Killer Cell Cytokine Production Threonine-type Endopeptidase Activity Regulation Of Natural Killer Cell Cytokine Production Proteasome Core Complex, Beta-subunit Complex Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Positive Regulation Of T Cell Mediated Immunity Identical Protein Binding Endoplasmic Reticulum Proteasome Core Complex Regulation Of Leukocyte Mediated Cytotoxicity Negative Regulation Of Innate Immune Response Bile Acid And Bile Salt Transport Recycling Endosome Membrane Regulation Of T Cell Mediated Immunity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Lymphocyte Mediated Immunity Nitrate Transmembrane Transporter Activity Protein Binding Membrane Endoplasmic Reticulum Membrane 14-3-3 Protein Binding Adaptive Immune Response Negative Regulation Of T Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Negative Regulation Of Natural Killer Cell Degranulation
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