PDIA3 and ERP27

Number of citations of the paper that reports this interaction (PubMedID 16940051)
0

Data Source:
HPRD (in vivo, in vitro)

		PDIA3	ERP27
Description		protein disulfide isomerase family A member 3	endoplasmic reticulum protein 27
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GO Annotations	Cellular Component	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Focal Adhesion Cell Surface Melanosome MHC Class I Peptide Loading Complex Phagocytic Vesicle Recycling Endosome Membrane Tapasin-ERp57 Complex Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Isomerase Activity Identical Protein Binding LncRNA Binding	Protein Disulfide Isomerase Activity Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class I Protein Complex Protein Folding Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Platelet Aggregation Extrinsic Apoptotic Signaling Pathway Cellular Response To Interleukin-7 Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Folding Response To Unfolded Protein Response To Endoplasmic Reticulum Stress
Pathways		ER-Phagosome pathway ER-Phagosome pathway Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576) Lead levels ( 26025379) Liver volume ( 34128465) Triglyceride levels ( 32203549)	Finger osteoarthritis severity (hand Klsum) ( 33055079) Hand grip strength ( 29313844) Hand osteoarthritis severity (hand Klsum) ( 33055079) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Osteoarthritis of the hand ( 28855172)
Interacting Genes		25 interacting genes: APP BACE1 CALR CANX CEBPA CFTR ERO1A ERP27 ESR1 GYPC HLA-A IFNG LINC01554 MDM2 MTNR1B OGT PCAT1 PCBP2 RBFOX2 SLC12A3 SLC2A1 STAT3 SUMO4 TAP1 UBE3A	10 interacting genes: BLOC1S2 C12orf60 GOLGA8F MED20 PDIA3 SGTA UBL4A UBQLN1 UBQLN2 UBQLN4
Entrez ID		2923	121506
HPRD ID		03625	08723
Ensembl ID		ENSG00000167004	ENSG00000139055
Uniprot IDs		P30101 V9HVY3	F5GYS6 Q96DN0
PDB IDs		2ALB 2DMM 2H8L 3F8U 6ENY 7QNG 7QPD	2L4C 4F9Z
Enriched GO Terms of Interacting Partners?		MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Chemical Homeostasis Protein Folding In Endoplasmic Reticulum Regulation Of Glycolytic Process Intracellular Receptor Signaling Pathway Homeostatic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of ATP Metabolic Process Cellular Homeostasis Endoplasmic Reticulum Lumen Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Response To Hormone Response To Stress Negative Regulation Of RNA Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Intracellular Signal Transduction Amyloid Fibril Formation Lumenal Side Of Endoplasmic Reticulum Membrane Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Protein-containing Complex Response To Ketone Positive Regulation Of ATP Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Proteolysis Response To Lipid Presynapse Response To Endoplasmic Reticulum Stress Positive Regulation Of Nitric Oxide Metabolic Process Enzyme Binding Regulation Of Generation Of Precursor Metabolites And Energy Organ Growth Regulation Of Protein Localization Cellular Response To Manganese Ion Hormone-mediated Signaling Pathway Monoatomic Cation Homeostasis Endoplasmic Reticulum Prostate Gland Growth L-ascorbic Acid Metabolic Process Monoatomic Ion Homeostasis Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Endocytosis Positive Regulation Of Interleukin-1 Beta Production Regulation Of Endocytosis	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Response To Endoplasmic Reticulum Stress Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Targeting To ER Protein Insertion Into ER Membrane Macromolecule Catabolic Process Regulation Of Cellular Response To Stress Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Macroautophagy Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Autophagy Negative Regulation Of Store-operated Calcium Channel Activity Protein Targeting To Membrane Protein Insertion Into Membrane Cellular Response To Stress Tapasin-ERp57 Complex TRC Complex Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Autophagy Nuclear Proteasome Complex Autophagosome Assembly Autophagosome Organization BAT3 Complex Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Identical Protein Binding Extrinsic Apoptotic Signaling Pathway Proteasomal Protein Catabolic Process BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Catabolic Process Cytosolic Proteasome Complex Positive Regulation Of Catabolic Process
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