PDIA3 and SLC12A3

Number of citations of the paper that reports this interaction (PMID 11832422)
1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vivo)

		PDIA3	SLC12A3
Gene Name		protein disulfide isomerase family A, member 3	solute carrier family 12 (sodium/chloride transporter), member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Cell Surface Melanosome Extracellular Vesicular Exosome	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Poly(A) RNA Binding	Transporter Activity Protein Binding Sodium:chloride Symporter Activity
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Folding Proteolysis Protein Import Into Nucleus Protein Retention In ER Lumen Signal Transduction Protein N-linked Glycosylation Via Asparagine Response To Endoplasmic Reticulum Stress Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Post-translational Protein Modification Cellular Protein Metabolic Process Cell Redox Homeostasis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Transport Ion Transport Sodium Ion Transport Chloride Transport Sodium Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Antigen processing-Cross presentation ER-Phagosome pathway Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle	Transport of inorganic cations/anions and amino acids/oligopeptides Cation-coupled Chloride cotransporters SLC-mediated transmembrane transport
Drugs			Bendroflumethiazide Metolazone Benzthiazide Chlorothiazide Hydrochlorothiazide Diazoxide Polythiazide Quinethazone
Diseases
GWAS			HDL cholesterol ( 20031564 23505323)
Protein-Protein Interactions		15 interactors: APP BACE1 CALR CANX ERO1L ERP27 GYPC HLA-A IFNG MDM2 SLC12A3 SLC2A1 STAT3 SUMO4 TAP1	2 interactors: PDIA3 WNK4
Entrez ID		2923	6559
HPRD ID		03625	02984
Ensembl ID		ENSG00000167004	ENSG00000070915
Uniprot IDs		G5EA52 P30101	J3QSS1 P55017
PDB IDs		2ALB 2DMM 2H8L 3F8U
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Localization To Nucleus Chaperone-mediated Protein Folding Antigen Processing And Presentation Of Peptide Antigen Cellular Localization Response To Stress Protein Maturation By Protein Folding Endoplasmic Reticulum Unfolded Protein Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cellular Response To Unfolded Protein Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cytoplasmic Transport Negative Regulation Of Cell Development ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Antigen Processing And Presentation Of Endogenous Antigen Establishment Of Localization In Cell Defense Response Homeostatic Process Response To Unfolded Protein Immune System Process Chemical Homeostasis Establishment Of Protein Localization Intracellular Transport Response To Endoplasmic Reticulum Stress Response To Drug Protein Localization To Organelle Viral Process Intracellular Receptor Signaling Pathway Response To Estrogen Protein Maturation Transport Cellular Response To Organic Substance Protein Localization Nucleocytoplasmic Transport Nuclear Transport Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein Folding Regulation Of Neurogenesis Positive Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Neurogenesis Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Negative Regulation Of Cell Differentiation Cellular Protein Localization Calcium Ion Homeostasis Peptide Antigen Assembly With MHC Class I Protein Complex	Distal Tubule Morphogenesis Renal Sodium Ion Absorption Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport Protein Retention In ER Lumen Maintenance Of Protein Localization In Endoplasmic Reticulum Renal Absorption Distal Tubule Development Homeostatic Process Protein Localization Nephron Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Renal Tubule Morphogenesis Renal System Process Renal Tubule Development Protein N-linked Glycosylation Via Asparagine Kidney Morphogenesis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Protein N-linked Glycosylation Protein Import Into Nucleus Cell Redox Homeostasis Nuclear Import Protein Localization To Endoplasmic Reticulum Chloride Transport Maintenance Of Protein Location In Cell Nephron Development Maintenance Of Protein Location Maintenance Of Location In Cell Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Import Kidney Epithelium Development Response To Endoplasmic Reticulum Stress Protein Localization To Nucleus Negative Regulation Of Secretion Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Post-translational Protein Modification
Tagcloud ?		calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia2 pdia4 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization	adaptations adjustments alpha1beta1 arystarkhova ascending atpase compensatory convoluted cotransporter dct fxyd fxyd2 generates hypoplasia na ncc nephron nkcc2 nonetheless permissive reabsorption s71 segment t53 thiazide thick tubule twofold
Tagcloud (Difference) ?		calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia2 pdia4 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization	adaptations adjustments alpha1beta1 arystarkhova ascending atpase compensatory convoluted cotransporter dct fxyd fxyd2 generates hypoplasia na ncc nephron nkcc2 nonetheless permissive reabsorption s71 segment t53 thiazide thick tubule twofold
Tagcloud (Intersection) ?