PDIA3 and SLC12A3

Number of citations of the paper that reports this interaction (PubMedID 11832422)
0

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, two hybrid)

		PDIA3	SLC12A3
Description		protein disulfide isomerase family A member 3	solute carrier family 12 member 3
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Focal Adhesion Cell Surface Melanosome MHC Class I Peptide Loading Complex Phagocytic Vesicle Recycling Endosome Membrane Tapasin-ERp57 Complex Extracellular Exosome	Cytosol Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Isomerase Activity Identical Protein Binding LncRNA Binding	Nucleotide Binding Protein Binding ATP Binding Sodium:potassium:chloride Symporter Activity Sodium Ion Transmembrane Transporter Activity Symporter Activity Chloride:monoatomic Cation Symporter Activity Sodium:chloride Symporter Activity Transmembrane Transporter Activity
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class I Protein Complex Protein Folding Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Platelet Aggregation Extrinsic Apoptotic Signaling Pathway Cellular Response To Interleukin-7 Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Monoatomic Ion Transport Sodium Ion Transport Cell Volume Homeostasis Sodium Ion Transmembrane Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Transmembrane Transport Renal Sodium Ion Absorption Response To Salt Chloride Transmembrane Transport Response To Aldosterone Potassium Ion Import Across Plasma Membrane
Pathways		ER-Phagosome pathway ER-Phagosome pathway Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Cation-coupled Chloride cotransporters Defective SLC12A3 causes Gitelman syndrome (GS)
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Bendroflumethiazide Metolazone Benzthiazide Indapamide Chlorothiazide Hydrochlorothiazide Trichlormethiazide Polythiazide Quinethazone
Diseases
GWAS		Blood protein levels ( 30072576) Lead levels ( 26025379) Liver volume ( 34128465) Triglyceride levels ( 32203549)	HDL cholesterol ( 20031564 23505323) HDL cholesterol levels ( 26763881) HDL levels x fish oil supplementation interaction (1df) ( 33760818) HDL levels x fish oil supplementation interaction (2df) ( 33760818) Phoneme awareness ( 30741946)
Interacting Genes		25 interacting genes: APP BACE1 CALR CANX CEBPA CFTR ERO1A ERP27 ESR1 GYPC HLA-A IFNG LINC01554 MDM2 MTNR1B OGT PCAT1 PCBP2 RBFOX2 SLC12A3 SLC2A1 STAT3 SUMO4 TAP1 UBE3A	2 interacting genes: PDIA3 WNK4
Entrez ID		2923	6559
HPRD ID		03625	02984
Ensembl ID		ENSG00000167004	ENSG00000070915
Uniprot IDs		P30101 V9HVY3	J3QSS1 P55017
PDB IDs		2ALB 2DMM 2H8L 3F8U 6ENY 7QNG 7QPD	7Y6I 7YG0 7YG1 8FHN 8FHO 8FHP 8FHQ 8FHR 8FHT 8VPN 8VPP 9BWT
Enriched GO Terms of Interacting Partners?		MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Chemical Homeostasis Protein Folding In Endoplasmic Reticulum Regulation Of Glycolytic Process Intracellular Receptor Signaling Pathway Homeostatic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of ATP Metabolic Process Cellular Homeostasis Endoplasmic Reticulum Lumen Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Response To Hormone Response To Stress Negative Regulation Of RNA Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Intracellular Signal Transduction Amyloid Fibril Formation Lumenal Side Of Endoplasmic Reticulum Membrane Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Protein-containing Complex Response To Ketone Positive Regulation Of ATP Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Proteolysis Response To Lipid Presynapse Response To Endoplasmic Reticulum Stress Positive Regulation Of Nitric Oxide Metabolic Process Enzyme Binding Regulation Of Generation Of Precursor Metabolites And Energy Organ Growth Regulation Of Protein Localization Cellular Response To Manganese Ion Hormone-mediated Signaling Pathway Monoatomic Cation Homeostasis Endoplasmic Reticulum Prostate Gland Growth L-ascorbic Acid Metabolic Process Monoatomic Ion Homeostasis Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Endocytosis Positive Regulation Of Interleukin-1 Beta Production Regulation Of Endocytosis	Aldosterone Secretion Disulfide Oxidoreductase Activity Protein Folding In Endoplasmic Reticulum Phospholipase C Activity Cellular Response To Interleukin-7 MHC Class I Peptide Loading Complex Response To Interleukin-7 Tapasin-ERp57 Complex Peptide Antigen Assembly With MHC Class I Protein Complex Nephron Tubule Morphogenesis Negative Regulation Of Sodium Ion Transport Chloride Ion Binding Renal Tubule Morphogenesis Lipid Export From Cell Negative Regulation Of Pancreatic Juice Secretion Regulation Of Potassium Ion Export Across Plasma Membrane Distal Tubule Morphogenesis Ion Channel Inhibitor Activity Intracellular Chloride Ion Homeostasis Response To Dietary Excess Chloride Ion Homeostasis Protein Disulfide Isomerase Activity Monoatomic Anion Homeostasis Renal Sodium Ion Absorption Renal Sodium Ion Transport Protein-disulfide Reductase Activity LncRNA Binding Negative Regulation Of Protein Localization To Plasma Membrane Renal Absorption Platelet Aggregation ERK1 And ERK2 Cascade Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Homotypic Cell-cell Adhesion Macrophage Activation Regulation Of Potassium Ion Transmembrane Transport Cellular Response To Xenobiotic Stimulus Regulation Of Sodium Ion Transport Energy Homeostasis Cell Body Phagocytic Vesicle Regulation Of Potassium Ion Transport Hormone Secretion Recycling Endosome Membrane Melanosome Immune System Process Hormone Transport Negative Regulation Of Monoatomic Ion Transport Chloride Transport Epithelial Tube Morphogenesis
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