PDIA3 and ERO1L

Number of citations of the paper that reports this interaction (PMID 17170699)
39

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PDIA3	ERO1L
Gene Name		protein disulfide isomerase family A, member 3	ERO1-like (S. cerevisiae)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Cell Surface Melanosome Extracellular Vesicular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Poly(A) RNA Binding	Protein Disulfide Isomerase Activity Protein Binding Protein Disulfide Oxidoreductase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Folding Proteolysis Protein Import Into Nucleus Protein Retention In ER Lumen Signal Transduction Protein N-linked Glycosylation Via Asparagine Response To Endoplasmic Reticulum Stress Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Post-translational Protein Modification Cellular Protein Metabolic Process Cell Redox Homeostasis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Response To Reactive Oxygen Species Protein Folding Cellular Protein Modification Process Response To Temperature Stimulus 4-hydroxyproline Metabolic Process Protein Maturation By Protein Folding Extracellular Matrix Organization Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress Cellular Protein Metabolic Process Cell Redox Homeostasis Brown Fat Cell Differentiation Chaperone Mediated Protein Folding Requiring Cofactor Release Of Sequestered Calcium Ion Into Cytosol Oxidation-reduction Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Antigen processing-Cross presentation ER-Phagosome pathway Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle	Peptide hormone metabolism Detoxification of Reactive Oxygen Species Insulin processing
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		15 interactors: APP BACE1 CALR CANX ERO1L ERP27 GYPC HLA-A IFNG MDM2 SLC12A3 SLC2A1 STAT3 SUMO4 TAP1	6 interactors: APPBP2 ERP44 P4HB PDIA3 PDILT PELI2
Entrez ID		2923	30001
HPRD ID		03625	13278
Ensembl ID		ENSG00000167004
Uniprot IDs		G5EA52 P30101	Q96HE7
PDB IDs		2ALB 2DMM 2H8L 3F8U	3AHQ 3AHR
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Localization To Nucleus Chaperone-mediated Protein Folding Antigen Processing And Presentation Of Peptide Antigen Cellular Localization Response To Stress Protein Maturation By Protein Folding Endoplasmic Reticulum Unfolded Protein Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cellular Response To Unfolded Protein Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cytoplasmic Transport Negative Regulation Of Cell Development ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Antigen Processing And Presentation Of Endogenous Antigen Establishment Of Localization In Cell Defense Response Homeostatic Process Response To Unfolded Protein Immune System Process Chemical Homeostasis Establishment Of Protein Localization Intracellular Transport Response To Endoplasmic Reticulum Stress Response To Drug Protein Localization To Organelle Viral Process Intracellular Receptor Signaling Pathway Response To Estrogen Protein Maturation Transport Cellular Response To Organic Substance Protein Localization Nucleocytoplasmic Transport Nuclear Transport Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein Folding Regulation Of Neurogenesis Positive Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Neurogenesis Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Negative Regulation Of Cell Differentiation Cellular Protein Localization Calcium Ion Homeostasis Peptide Antigen Assembly With MHC Class I Protein Complex	Cell Redox Homeostasis Protein Folding Response To Endoplasmic Reticulum Stress Cellular Homeostasis Homeostatic Process Cellular Protein Metabolic Process
Tagcloud ?		calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia2 pdia4 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Difference) ?		calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia2 pdia4 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Intersection) ?