SETD2 and HTT

Number of citations of the paper that reports this interaction (PMID 9700202)
73

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		SETD2	HTT
Gene Name		SET domain containing 2	huntingtin
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Chromosome	Nucleus Nucleoplasm Cytoplasm Mitochondrion Late Endosome Autophagic Vacuole Endoplasmic Reticulum Golgi Apparatus Cytosol Inclusion Body Axon Dendrite Cytoplasmic Vesicle Membrane Protein Complex
	Molecular Function	Protein Binding Histone-lysine N-methyltransferase Activity	P53 Binding Protein Binding Transcription Factor Binding Dynactin Binding Identical Protein Binding Ion Channel Binding Dynein Intermediate Chain Binding Beta-tubulin Binding Diazepam Binding
	Biological Process	Angiogenesis Morphogenesis Of A Branching Structure Neural Tube Closure Mismatch Repair Chromatin Organization Regulation Of Transcription, DNA-templated Transcription Elongation From RNA Polymerase II Promoter Regulation Of MRNA Export From Nucleus Forebrain Development Nucleosome Organization Cell Migration Involved In Vasculogenesis Mesoderm Morphogenesis Embryonic Cranial Skeleton Morphogenesis Stem Cell Development Pericardium Development Embryonic Placenta Morphogenesis Coronary Vasculature Morphogenesis Histone H3-K36 Trimethylation	Urea Cycle Citrulline Metabolic Process Establishment Of Mitotic Spindle Orientation Protein Import Into Nucleus ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Endoplasmic Reticulum Organization Golgi Organization Dopamine Receptor Signaling Pathway Spermatogenesis Cell Aging Grooming Behavior Locomotory Behavior Axon Cargo Transport Determination Of Adult Lifespan Visual Learning Anterior/posterior Pattern Specification Endosomal Transport Lactate Biosynthetic Process From Pyruvate Quinolinate Biosynthetic Process Striatum Development Olfactory Lobe Development Neural Plate Formation Insulin Secretion Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Phosphatase Type 2A Activity Social Behavior Hormone Metabolic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Vesicle Transport Along Microtubule Regulation Of Synaptic Plasticity Paraxial Mesoderm Formation Organ Development Neuron Development Neuron Apoptotic Process Response To Calcium Ion Regulation Of Mitochondrial Membrane Potential L-glutamate Import Iron Ion Homeostasis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ATXN1 CIC HIST1H3A HIST3H3 HTT POLR2A SIAH2 SMAD3	108 interactors: AKT1 AMFR AP2A2 CASP1 CASP3 CASP6 CBS CHD3 CHUK CREBBP CRMP1 CTBP1 DLG4 DNALI1 DPPA4 DUSP10 ECH1 EGFR ERCC6L ETV4 EVL F8A1 FEZ1 FICD FTL GAPDH GGA2 GIT1 GOLPH3L GPRASP2 GRB2 HAP1 HEYL HIP1 HIP1R HIST1H3H HOXC11 HOXC4 HSPA8 HYPK HYPM IFT20 IKBKAP IKBKB IKBKG ING5 KAT2B KIAA1377 MAGEA3 MAGEB18 MAGEB6 MAP3K10 MBD1 MED21 MED31 MID1 MRFAP1 MRFAP1L1 MTSS1 NCOR1 NUPL1 OPTN OSTF1 PACSIN1 PDK2 PEX11B PFN2 PIAS1 PIAS4 PIK3R1 PML PPP2CA PRPF40A PRPF40B PSMC5 RASA1 REST RNF20 RPS6KB1 SAP30 SETD2 SH3GL3 SH3GLB1 SIN3A SP1 SUMO1 SYMPK TACC1 TAF4 TBP TCERG1 TGM2 TP53 TPR TRAFD1 TRIP10 TTC23 TUBB UBAC1 UBE2E3 UBE2K UTP14A VCP XRCC6 ZDHHC17 ZFYVE19 ZNF451 ZNF655
Entrez ID		29072	3064
HPRD ID		11043	00883
Ensembl ID		ENSG00000181555	ENSG00000197386
Uniprot IDs		Q9BYW2	P42858
PDB IDs		2A7O 4FMU 4H12	2D3X 2LD0 2LD2 3IO4 3IO6 3IOR 3IOT 3IOU 3IOV 3IOW 3LRH 4FE8 4FEB 4FEC 4FED
Enriched GO Terms of Interacting Partners?		Paraxial Mesoderm Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Paraxial Mesoderm Development Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Lung Alveolus Development Visual Learning Visual Behavior Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Associative Learning Neural Plate Formation Positive Regulation Of Transforming Growth Factor Beta3 Production Mesoderm Formation Negative Regulation Of Signaling Mesoderm Morphogenesis Regulation Of Phosphatase Activity Gene Silencing Negative Regulation Of Gene Expression Serotonin Uptake Transcription, RNA-templated Lactate Biosynthetic Process From Pyruvate RNA Processing Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Dephosphorylation Formation Of Primary Germ Layer Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of RNA Metabolic Process Learning Mesoderm Development Positive Regulation Of Gene Expression Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Phosphatase Type 2A Activity Evasion Or Tolerance Of Host Defenses By Virus Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Tube Development Quinolinate Biosynthetic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Synaptic Transmission, Dopaminergic Cellular Aromatic Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Cell Differentiation	Positive Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression RNA Metabolic Process Transcription, DNA-templated Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Regulation Of Transcription, DNA-templated Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Response To Growth Factor Cellular Response To Organic Substance Macromolecule Biosynthetic Process Viral Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Response To Organic Substance Cellular Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Signaling Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Gene Expression Regulation Of Protein Metabolic Process Developmental Process Transcription From RNA Polymerase II Promoter Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cell Communication Regulation Of Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process
Tagcloud ?		cpg cues de dense dnmt1 dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects transcribed	1s 2a 3s 4c 4r 9r aryl carbomethoxy carboxylic dat esters ethylene flattened fluorophenyl isomers methylenedioxy nortropane paroxetine phenoxy piperidine possesses pseudoequatorial reuptake serotonin ssri stereochemistry substituent substituents win
Tagcloud (Difference) ?		cpg cues de dense dnmt1 dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects transcribed	1s 2a 3s 4c 4r 9r aryl carbomethoxy carboxylic dat esters ethylene flattened fluorophenyl isomers methylenedioxy nortropane paroxetine phenoxy piperidine possesses pseudoequatorial reuptake serotonin ssri stereochemistry substituent substituents win
Tagcloud (Intersection) ?