SETD2 and GMPPB

Data Source: HiPPIP (Novel)

		SETD2	GMPPB
Name		SET domain containing 2, histone lysine methyltransferase	GDP-mannose pyrophosphorylase B
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm	Cytoplasm Cytosol GDP-mannose Pyrophosphorylase Complex
	Molecular Function	Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Alpha-tubulin Binding Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K36 Trimethyltransferase Activity	Nucleotide Binding Mannose-1-phosphate Guanylyltransferase (GTP) Activity Protein Binding GTP Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding
	Biological Process	Autophagosome Assembly Immune System Process DNA Repair Mismatch Repair Chromatin Organization Regulation Of DNA-templated Transcription Transcription Elongation By RNA Polymerase II DNA Damage Response Response To Metal Ion Regulation Of Gene Expression Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of MRNA Export From Nucleus Peptidyl-lysine Trimethylation Cell Differentiation Methylation Regulation Of Cytokinesis Positive Regulation Of Interferon-alpha Production Response To Type I Interferon Nucleosome Organization Endodermal Cell Differentiation Response To Alkaloid Innate Immune Response Positive Regulation Of Ossification Stem Cell Differentiation Defense Response To Virus Protein K48-linked Ubiquitination Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Protein Localization To Chromatin	Protein Glycosylation GDP-mannose Biosynthetic Process GDP-mannose Metabolic Process GDP-mannose Biosynthetic Process From Mannose
Pathways		PKMTs methylate histone lysines	Synthesis of GDP-mannose
GWAS		Adult body size ( 32376654 ) Basophil count ( 32888494 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Granulocyte percentage of myeloid white cells ( 27863252 ) HDL cholesterol ( 24097068 30275531 ) HDL cholesterol levels ( 28334899 ) Huntington's disease progression ( 28642124 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Mean platelet volume ( 32888494 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Monocyte count ( 27863252 ) Monocyte percentage of white cells ( 32888494 27863252 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Platelet distribution width ( 32888494 27863252 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Refractive error ( 32231278 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 ) White blood cell count ( 27863252 32888494 ) White blood cell count (basophil) ( 27863252 )	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Extremely high intelligence ( 29520040 ) Multisite chronic pain ( 31194737 ) Regular attendance at a gym or sports club ( 29970889 ) Regular attendance at a religious group ( 29970889 ) Resting heart rate ( 27798624 ) Sleep duration (short sleep) ( 30846698 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 21297633 )
Novel Interactors		6 novel interactors: EXOSC7 GMPPB KLHL18 NDUFAF3 TEX264 TMA7	1 novel interactors: SETD2
Interacting Genes		10 interacting genes: ARX ATXN1 CIC H3-4 H3C1 HTT SHANK3 SIAH2 SMAD3 SPOP	5 interacting genes: DPPA4 GLYCTK GMPPA POLR1C TXNDC5
Entrez ID		29072	29925
HPRD ID		11043	13589
Ensembl ID		ENSG00000181555	ENSG00000173540
Uniprot IDs		A0A1W2PPX9 Q9BYW2	Q9Y5P6
PDB IDs		2A7O 2MDC 2MDI 2MDJ 4FMU 4H12 5JJY 5JLB 5JLE 5LSS 5LSX 5LSY 5LSZ 5LT6 5LT7 5LT8 5V21 5V22 6J9J 6VDB 7EA8 7EVR 7EVS 7LZB 7LZD 7LZF 7TY2 7TY3 8Q5P 8RZU 9EGZ 9EH0 9EH1 9EH2	7D72 7D73 7D74
GO Terms Enriched among Interactors		Vocal Learning Learning Social Behavior Observational Learning Auditory Behavior Learning Or Memory Mechanosensory Behavior Cognition Memory Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Chromatin Binding Proteasomal Protein Catabolic Process Lung Alveolus Development	Molecular Sensor Activity GDP-mannose Pyrophosphorylase Complex Mannose-1-phosphate Guanylyltransferase (GTP) Activity Fructose Catabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Glycerate Kinase Activity