SETD2 and CIC

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SETD2	CIC
Gene Name		SET domain containing 2	capicua transcriptional repressor
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Chromosome	Nucleus
	Molecular Function	Protein Binding Histone-lysine N-methyltransferase Activity	DNA Binding Chromatin Binding Protein Binding
	Biological Process	Angiogenesis Morphogenesis Of A Branching Structure Neural Tube Closure Mismatch Repair Chromatin Organization Regulation Of Transcription, DNA-templated Transcription Elongation From RNA Polymerase II Promoter Regulation Of MRNA Export From Nucleus Forebrain Development Nucleosome Organization Cell Migration Involved In Vasculogenesis Mesoderm Morphogenesis Embryonic Cranial Skeleton Morphogenesis Stem Cell Development Pericardium Development Embryonic Placenta Morphogenesis Coronary Vasculature Morphogenesis Histone H3-K36 Trimethylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Lung Alveolus Development
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ATXN1 CIC HIST1H3A HIST3H3 HTT POLR2A SIAH2 SMAD3	13 interactors: ATXN1 CENPJ CSNK2B GABPB1 GTPBP3 NFYC PICK1 PLK1 PYCR2 SEC62 SETD2 TRIM22 ZNRD1
Entrez ID		29072	23152
HPRD ID		11043	10831
Ensembl ID		ENSG00000181555	ENSG00000079432
Uniprot IDs		Q9BYW2	Q96RK0
PDB IDs		2A7O 4FMU 4H12	4J2J 4J2L
Enriched GO Terms of Interacting Partners?		Paraxial Mesoderm Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Paraxial Mesoderm Development Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Lung Alveolus Development Visual Learning Visual Behavior Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Associative Learning Neural Plate Formation Positive Regulation Of Transforming Growth Factor Beta3 Production Mesoderm Formation Negative Regulation Of Signaling Mesoderm Morphogenesis Regulation Of Phosphatase Activity Gene Silencing Negative Regulation Of Gene Expression Serotonin Uptake Transcription, RNA-templated Lactate Biosynthetic Process From Pyruvate RNA Processing Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Dephosphorylation Formation Of Primary Germ Layer Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of RNA Metabolic Process Learning Mesoderm Development Positive Regulation Of Gene Expression Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Phosphatase Type 2A Activity Evasion Or Tolerance Of Host Defenses By Virus Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Tube Development Quinolinate Biosynthetic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Synaptic Transmission, Dopaminergic Cellular Aromatic Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Cell Differentiation	Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Histone H3-K36 Trimethylation RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Elongation Activation Of APC-Cdc20 Complex Activity Cellular Aromatic Compound Metabolic Process Centrosome Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Cell Migration Involved In Vasculogenesis Microtubule Organizing Center Organization Cellular Nitrogen Compound Metabolic Process G2/M Transition Of Mitotic Cell Cycle Polar Body Extrusion After Meiotic Divisions Cellular Metabolic Process Activation Of Anaphase-promoting Complex Activity Meiotic Cytokinesis L-proline Biosynthetic Process Posttranslational Protein Targeting To Membrane Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Activin Receptor Signaling Pathway DNA Methylation Involved In Embryo Development Adiponectin-activated Signaling Pathway Regulation Of MRNA Export From Nucleus Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Metaphase/anaphase Transition Of Mitotic Cell Cycle Histone H3-K36 Methylation Dendritic Spine Maintenance Regulation Of Metabolic Process Regulation Of Gene Expression, Epigenetic Positive Regulation Of Metabolic Process Tube Development Coronary Vasculature Morphogenesis Endothelial Tube Morphogenesis Gene Expression Regulation Of Centriole Replication Protein Localization To Chromatin Neuronal Ion Channel Clustering Mitotic Cell Cycle Regulation Of RNA Export From Nucleus Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Tagcloud ?		cpg cues de dense dnmt1 dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects transcribed	aetiology assumed bacteriuria catheterization clean complaints distress epq evaluations eysenck ghq intermittent inventory neurogenic neurotic neuroticism personality practised prescription psychometric spielberger stai thirds tolerability trait undergone unnecessary verify x1
Tagcloud (Difference) ?		cpg cues de dense dnmt1 dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects transcribed	aetiology assumed bacteriuria catheterization clean complaints distress epq evaluations eysenck ghq intermittent inventory neurogenic neurotic neuroticism personality practised prescription psychometric spielberger stai thirds tolerability trait undergone unnecessary verify x1
Tagcloud (Intersection) ?