SETD2 and KLHL18

Data Source: HiPPIP (Novel)

		SETD2	KLHL18
Name		SET domain containing 2, histone lysine methyltransferase	kelch like family member 18
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm	Cytoplasm Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Alpha-tubulin Binding Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K36 Trimethyltransferase Activity	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Autophagosome Assembly Immune System Process DNA Repair Mismatch Repair Chromatin Organization Regulation Of DNA-templated Transcription Transcription Elongation By RNA Polymerase II DNA Damage Response Response To Metal Ion Regulation Of Gene Expression Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of MRNA Export From Nucleus Peptidyl-lysine Trimethylation Cell Differentiation Methylation Regulation Of Cytokinesis Positive Regulation Of Interferon-alpha Production Response To Type I Interferon Nucleosome Organization Endodermal Cell Differentiation Response To Alkaloid Innate Immune Response Positive Regulation Of Ossification Stem Cell Differentiation Defense Response To Virus Protein K48-linked Ubiquitination Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Protein Localization To Chromatin	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Division Positive Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		PKMTs methylate histone lysines	None
GWAS		Adult body size ( 32376654 ) Basophil count ( 32888494 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Granulocyte percentage of myeloid white cells ( 27863252 ) HDL cholesterol ( 24097068 30275531 ) HDL cholesterol levels ( 28334899 ) Huntington's disease progression ( 28642124 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Mean platelet volume ( 32888494 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Monocyte count ( 27863252 ) Monocyte percentage of white cells ( 32888494 27863252 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Platelet distribution width ( 32888494 27863252 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Refractive error ( 32231278 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 ) White blood cell count ( 27863252 32888494 ) White blood cell count (basophil) ( 27863252 )	Huntington's disease progression ( 28642124 ) Refractive error ( 32231278 )
Novel Interactors		6 novel interactors: EXOSC7 GMPPB KLHL18 NDUFAF3 TEX264 TMA7	2 novel interactors: SCAP SETD2
Interacting Genes		10 interacting genes: ARX ATXN1 CIC H3-4 H3C1 HTT SHANK3 SIAH2 SMAD3 SPOP	3 interacting genes: AURKA CFTR EEF1G
Entrez ID		29072	23276
HPRD ID		11043	10017
Ensembl ID		ENSG00000181555	ENSG00000114648
Uniprot IDs		A0A1W2PPX9 Q9BYW2	O94889
PDB IDs		2A7O 2MDC 2MDI 2MDJ 4FMU 4H12 5JJY 5JLB 5JLE 5LSS 5LSX 5LSY 5LSZ 5LT6 5LT7 5LT8 5V21 5V22 6J9J 6VDB 7EA8 7EVR 7EVS 7LZB 7LZD 7LZF 7TY2 7TY3 8Q5P 8RZU 9EGZ 9EH0 9EH1 9EH2	Not available
GO Terms Enriched among Interactors		Vocal Learning Learning Social Behavior Observational Learning Auditory Behavior Learning Or Memory Mechanosensory Behavior Cognition Memory Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Chromatin Binding Proteasomal Protein Catabolic Process Lung Alveolus Development	Sterol Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Cytokinesis Microtubule Cytoskeleton Organization Involved In Mitosis Response To Vitamin B3 SREBP-SCAP Complex Positive Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Regulation Of Cell Division Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Histone H3S10 Kinase Activity Positive Regulation Of Oocyte Maturation Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Alcohol Metabolic Process Chloride Channel Inhibitor Activity Transepithelial Water Transport Steroid Metabolic Process Amelogenesis Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Basolateral Plasma Membrane Pronucleus Chromosome Passenger Complex Positive Regulation Of Cell Maturation Mitotic Centrosome Separation Axon Hillock Sterol Binding Negative Regulation Of Cholesterol Biosynthetic Process SREBP Signaling Pathway Negative Regulation Of Cholesterol Metabolic Process Cellular Response To Sterol Depletion Histone H3K36 Trimethyltransferase Activity Regulation Of Protein Localization To Chromatin Peptidyl-lysine Trimethylation ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of MRNA Export From Nucleus Histone H3K36 Methyltransferase Activity Cilium Disassembly Response To Sterol Depletion Centrosome Separation Spindle Assembly Involved In Female Meiosis Response To Type I Interferon