CDH2 and CDH4

Number of citations: 47 (PubMedID 10662782)
Data Source: HPRD (in vivo)

		CDH2	CDH4
Name		cadherin 2	cadherin 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Focal Adhesion Cell Surface Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Catenin Complex Lamellipodium Cell Junction Desmosome Cortical Actin Cytoskeleton Extracellular Matrix Sarcolemma Neuron Projection Plasma Membrane Raft Apical Part Of Cell Synapse Anchoring Junction Presynapse	Plasma Membrane Adherens Junction Membrane Catenin Complex
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding Alpha-catenin Binding Gamma-catenin Binding Cadherin Binding Metal Ion Binding	Calcium Ion Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Cell Morphogenesis Type B Pancreatic Cell Development Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synapse Assembly Glial Cell Differentiation Neural Crest Cell Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Telencephalon Development Cerebral Cortex Development Adherens Junction Organization Detection Of Muscle Stretch Positive Regulation Of MAPK Cascade Cell-cell Adhesion Mediated By Cadherin Blood Vessel Morphogenesis Brain Morphogenesis Homeostasis Of Number Of Cells Striated Muscle Cell Differentiation Radial Glial Cell Differentiation Neuroepithelial Cell Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Migration Synaptic Vesicle Clustering Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Neuronal Stem Cell Population Maintenance Cell-cell Adhesion Regulation Of Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Vesicle Clustering	Cell Morphogenesis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Axon Guidance Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Adherens Junction Organization Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Axon Extension Axon Extension Cell-cell Adhesion
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Adherens junctions interactions Myogenesis Myogenesis Post-translational protein phosphorylation Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	Adherens junctions interactions Myogenesis Myogenesis
GWAS		Breast cancer ( 29058716 ) Breast cancer (estrogen-receptor negative) ( 29058716 ) Daytime nap ( 33568662 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Lung function (FVC) ( 24023788 ) Metabolite levels ( 23823483 ) Obesity-related traits ( 23251661 ) Optic disc size ( 31809533 ) Periodontal disease-related phenotype (Socransky) ( 24347629 ) PR interval ( 32439900 ) Refractive error ( 32231278 ) Response to hepatitis B vaccine ( 29534301 ) Resting heart rate ( 27798624 ) Systemic lupus erythematosus ( 32771030 ) Temperament (bipolar disorder) ( 22365631 ) Type 2 diabetes ( 31049640 ) Urinary albumin-to-creatinine ratio in diabetes ( 31511532 ) vWF and FVIII levels ( 21810271 )	β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374 ) 3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134 ) Axial length ( 24144296 ) Cerebrospinal T-tau levels ( 20932310 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444 ) Erosive tooth wear (severe vs non-severe) ( 29898447 ) Erosive tooth wear (severe vs none or mild) ( 29898447 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Fish intake frequency ( 31320941 ) General cognitive ability ( 29844566 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Gut microbiota relative abundance (unassigned genus belonging to family Lachnospiraceae) ( 33208821 ) HDL cholesterol levels ( 32759990 ) Hip circumference adjusted for BMI ( 28552196 ) Household income (MTAG) ( 31844048 ) Longevity ( 20834067 ) Metabolite levels ( 23823483 ) Metabolite levels (X-11787) ( 23934736 ) Multiple system atrophy ( 27629089 ) Night sleep phenotypes ( 27126917 ) Obesity-related traits ( 23251661 ) Obstructive sleep apnea trait (average respiratory event duration) ( 26977737 ) Sudden cardiac arrest ( 21658281 ) Volumetric brain MRI ( 17903297 )
Novel Interactors		1 novel interactors: ADORA2A	None recorded
Interacting Genes		23 interacting genes: ARHGAP32 ARVCF BOC CDH11 CDH4 CDON CREBBP CTNNA1 CTNNB1 CTNND2 EXOC5 FGFR4 GNA12 GNA13 GRIK2 GRIN1 GRIN2D JUP LRRC7 PIK3R1 PKP4 PTPN1 UBC	3 interacting genes: CDH2 MTNR1B UBE2I
Entrez ID		1000	1002
HPRD ID		00226	04304
Ensembl ID		ENSG00000170558	ENSG00000179242
Uniprot IDs		C9J126 P19022	P55283
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Adherens Junction Cell-cell Adhesion Cadherin Binding Cell Adhesion Catenin Complex Regulation Of Cell Communication Regulation Of Signaling Plasma Membrane Regulation Of Signal Transduction Cell-cell Junction Assembly Cellular Response To Indole-3-methanol Response To Indole-3-methanol Cell-cell Junction Organization Glutamate-gated Calcium Ion Channel Activity Cell-cell Junction Cell Surface Receptor Signaling Pathway Postsynaptic Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signaling Cassette Postsynaptic Density Anatomical Structure Morphogenesis Cell Junction Assembly Excitatory Postsynaptic Potential D5 Dopamine Receptor Binding Cell Junction Organization Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Signal Transduction Catenin-TCF7L2 Complex Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Beta-catenin Binding Ligand-gated Monoatomic Ion Channel Activity Anchoring Junction Cellular Response To Oxygen-containing Compound Signal Transduction Cell-cell Adhesion Mediated By Cadherin Ligand-gated Ion Channel Signaling Pathway Rho-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Synaptic Transmission, Glutamatergic Regulation Of Neuroblast Proliferation Presynaptic Membrane Neuroblast Proliferation Intercalated Disc NMDA Glutamate Receptor Activity Glutamate Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission	Detection Of Muscle Stretch Regulation Of Oligodendrocyte Progenitor Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Synaptic Vesicle Clustering Regulation Of Synaptic Vesicle Clustering Regulation Of Postsynaptic Density Protein 95 Clustering Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep RING-like Zinc Finger Domain Binding SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding SUMO Conjugating Enzyme Activity Fascia Adherens Enzyme Binding Regulation Of Intracellular Signal Transduction Alpha-catenin Binding Mitotic Nuclear Membrane Reassembly Gamma-catenin Binding Synaptic Vesicle Clustering Type B Pancreatic Cell Development Radial Glial Cell Differentiation Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Transferase Complex Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Transmission Of Nerve Impulse Brain Morphogenesis Positive Regulation Of Circadian Rhythm Negative Regulation Of Nervous System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Transcription Factor Binding SUMO Transferase Activity Apicolateral Plasma Membrane Neuronal Stem Cell Population Maintenance Regulation Of Circadian Sleep/wake Cycle Synaptonemal Complex Telencephalon Development Response To Muscle Stretch Catenin Complex Neural Crest Cell Development Desmosome Positive Regulation Of Behavior