CDH2 and ARVCF

Number of citations: 106 (PubMedID 35271311)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro, in vivo)

		CDH2	ARVCF
Name		cadherin 2	ARVCF delta catenin family member
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Focal Adhesion Cell Surface Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Catenin Complex Lamellipodium Cell Junction Desmosome Cortical Actin Cytoskeleton Extracellular Matrix Sarcolemma Neuron Projection Plasma Membrane Raft Apical Part Of Cell Synapse Anchoring Junction Presynapse	Nucleus Cytoplasm Plasma Membrane Adherens Junction Anchoring Junction
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding Alpha-catenin Binding Gamma-catenin Binding Cadherin Binding Metal Ion Binding	Protein Binding Cadherin Binding
	Biological Process	Cell Morphogenesis Type B Pancreatic Cell Development Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synapse Assembly Glial Cell Differentiation Neural Crest Cell Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Telencephalon Development Cerebral Cortex Development Adherens Junction Organization Detection Of Muscle Stretch Positive Regulation Of MAPK Cascade Cell-cell Adhesion Mediated By Cadherin Blood Vessel Morphogenesis Brain Morphogenesis Homeostasis Of Number Of Cells Striated Muscle Cell Differentiation Radial Glial Cell Differentiation Neuroepithelial Cell Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Migration Synaptic Vesicle Clustering Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Neuronal Stem Cell Population Maintenance Cell-cell Adhesion Regulation Of Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Vesicle Clustering	MRNA Processing Cell Adhesion RNA Splicing Cell-cell Adhesion
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Adherens junctions interactions Myogenesis Myogenesis Post-translational protein phosphorylation Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	None
Diseases		None	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Breast cancer ( 29058716 ) Breast cancer (estrogen-receptor negative) ( 29058716 ) Daytime nap ( 33568662 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Lung function (FVC) ( 24023788 ) Metabolite levels ( 23823483 ) Obesity-related traits ( 23251661 ) Optic disc size ( 31809533 ) Periodontal disease-related phenotype (Socransky) ( 24347629 ) PR interval ( 32439900 ) Refractive error ( 32231278 ) Response to hepatitis B vaccine ( 29534301 ) Resting heart rate ( 27798624 ) Systemic lupus erythematosus ( 32771030 ) Temperament (bipolar disorder) ( 22365631 ) Type 2 diabetes ( 31049640 ) Urinary albumin-to-creatinine ratio in diabetes ( 31511532 ) vWF and FVIII levels ( 21810271 )	Appendicular lean mass ( 33097823 ) Central corneal thickness ( 29760442 32528159 ) Lymphocyte count ( 27863252 32888494 ) Medication use (antihypertensives) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Monocyte count ( 27863252 32888494 ) Neutrophil count ( 32888494 ) Platelet count ( 27863252 32888494 22139419 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 ) Pulse pressure ( 30578418 30487518 28739976 28135244 27841878 ) Systolic blood pressure ( 30578418 30487518 27841878 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) White blood cell count ( 27863252 32888494 )
Novel Interactors		1 novel interactors: ADORA2A	None recorded
Interacting Genes		23 interacting genes: ARHGAP32 ARVCF BOC CDH11 CDH4 CDON CREBBP CTNNA1 CTNNB1 CTNND2 EXOC5 FGFR4 GNA12 GNA13 GRIK2 GRIN1 GRIN2D JUP LRRC7 PIK3R1 PKP4 PTPN1 UBC	6 interacting genes: CDH1 CDH15 CDH2 ERBIN LNX1 TJP1
Entrez ID		1000	421
HPRD ID		00226	03778
Ensembl ID		ENSG00000170558	ENSG00000099889
Uniprot IDs		C9J126 P19022	C9JJX6 E9PDC3 O00192
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Adherens Junction Cell-cell Adhesion Cadherin Binding Cell Adhesion Catenin Complex Regulation Of Cell Communication Regulation Of Signaling Plasma Membrane Regulation Of Signal Transduction Cell-cell Junction Assembly Cellular Response To Indole-3-methanol Response To Indole-3-methanol Cell-cell Junction Organization Glutamate-gated Calcium Ion Channel Activity Cell-cell Junction Cell Surface Receptor Signaling Pathway Postsynaptic Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signaling Cassette Postsynaptic Density Anatomical Structure Morphogenesis Cell Junction Assembly Excitatory Postsynaptic Potential D5 Dopamine Receptor Binding Cell Junction Organization Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Signal Transduction Catenin-TCF7L2 Complex Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Beta-catenin Binding Ligand-gated Monoatomic Ion Channel Activity Anchoring Junction Cellular Response To Oxygen-containing Compound Signal Transduction Cell-cell Adhesion Mediated By Cadherin Ligand-gated Ion Channel Signaling Pathway Rho-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Synaptic Transmission, Glutamatergic Regulation Of Neuroblast Proliferation Presynaptic Membrane Neuroblast Proliferation Intercalated Disc NMDA Glutamate Receptor Activity Glutamate Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission	Adherens Junction Organization Cell-cell Junction Assembly Catenin Complex Cell Junction Organization Cell-cell Junction Organization Adherens Junction Cell-cell Adhesion Mediated By Cadherin Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Junction Cell Junction Assembly Cadherin Binding Cell Adhesion Beta-catenin Binding Anchoring Junction Gamma-catenin Binding Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Adhesion Cell Morphogenesis Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Apical Junction Complex Desmosome Postsynapse Basolateral Plasma Membrane Synapse Organization Cortical Actin Cytoskeleton Neuromuscular Junction Apical Part Of Cell Cell Adhesion Molecule Binding Synapse Assembly Positive Regulation Of Synaptic Vesicle Clustering Basal Protein Localization Calcium Ion Binding Epithelial Cell Development Neuroligin Clustering Involved In Postsynaptic Membrane Assembly ErbB-2 Class Receptor Binding Intracellular Protein Localization Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Regulation Of Postsynaptic Density Protein 95 Clustering Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Localization To Plasma Membrane Response To Heparin Cellular Response To Indole-3-methanol Lamellipodium Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Response To Indole-3-methanol Response To Gram-positive Bacterium Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Synaptic Vesicle Clustering Protein Localization To Bicellular Tight Junction