CDH2 and CDH11

Number of citations of the paper that reports this interaction (PubMedID 14625392)
0

Data Source:
HPRD (in vivo)

		CDH2	CDH11
Description		cadherin 2	cadherin 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Focal Adhesion Cell Surface Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Catenin Complex Lamellipodium Cell Junction Desmosome Cortical Actin Cytoskeleton Extracellular Matrix Sarcolemma Neuron Projection Plasma Membrane Raft Apical Part Of Cell Synapse Anchoring Junction Presynapse	Extracellular Region Cytoplasm Plasma Membrane Adherens Junction Membrane Catenin Complex Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding Alpha-catenin Binding Gamma-catenin Binding Cadherin Binding Metal Ion Binding	Calcium Ion Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Cell Morphogenesis Type B Pancreatic Cell Development Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synapse Assembly Glial Cell Differentiation Neural Crest Cell Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Telencephalon Development Cerebral Cortex Development Adherens Junction Organization Detection Of Muscle Stretch Positive Regulation Of MAPK Cascade Cell-cell Adhesion Mediated By Cadherin Blood Vessel Morphogenesis Brain Morphogenesis Homeostasis Of Number Of Cells Striated Muscle Cell Differentiation Radial Glial Cell Differentiation Neuroepithelial Cell Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Migration Synaptic Vesicle Clustering Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Neuronal Stem Cell Population Maintenance Cell-cell Adhesion Regulation Of Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Vesicle Clustering	Cell Morphogenesis Skeletal System Development Ossification Aortic Valve Formation Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Corticospinal Tract Morphogenesis Negative Regulation Of Cell Migration Cell-substrate Adhesion Adherens Junction Organization Cell-cell Adhesion Mediated By Cadherin Focal Adhesion Assembly Modulation Of Chemical Synaptic Transmission Cell-cell Adhesion
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Adherens junctions interactions Myogenesis Myogenesis Post-translational protein phosphorylation Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	Adherens junctions interactions Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 function Regulation of CDH11 function CDH11 homotypic and heterotypic interactions
Drugs			Celecoxib
Diseases
GWAS		Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Lung function (FVC) ( 24023788) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Periodontal disease-related phenotype (Socransky) ( 24347629) PR interval ( 32439900) Refractive error ( 32231278) Response to hepatitis B vaccine ( 29534301) Resting heart rate ( 27798624) Systemic lupus erythematosus ( 32771030) Temperament (bipolar disorder) ( 22365631) Type 2 diabetes ( 31049640) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) vWF and FVIII levels ( 21810271)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Blood protein levels ( 30072576) Cerebrospinal T-tau levels ( 26252872) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Deep white matter hyperintensities ( 32517579) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estrogen level change in anastrozole-treated breast cancer ( 32701512) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Hand grip strength ( 29691431) High density lipoprotein cholesterol levels ( 33339817) Intraocular pressure ( 29617998 29785010 30054594 31959993) Lung cancer in never smokers ( 28604730) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Schizophrenia ( 28991256) Systolic blood pressure ( 27841878) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		23 interacting genes: ARHGAP32 ARVCF BOC CDH11 CDH4 CDON CREBBP CTNNA1 CTNNB1 CTNND2 EXOC5 FGFR4 GNA12 GNA13 GRIK2 GRIN1 GRIN2D JUP LRRC7 PIK3R1 PKP4 PTPN1 UBC	4 interacting genes: CDH2 CTNNB1 CTNND1 MTNR1B
Entrez ID		1000	1009
HPRD ID		00226	08960
Ensembl ID		ENSG00000170558	ENSG00000140937
Uniprot IDs		C9J126 P19022	H3BUU9 P55287
PDB IDs
Enriched GO Terms of Interacting Partners?		Adherens Junction Cell-cell Adhesion Cadherin Binding Cell Adhesion Catenin Complex Regulation Of Cell Communication Regulation Of Signaling Plasma Membrane Regulation Of Signal Transduction Cell-cell Junction Assembly Cellular Response To Indole-3-methanol Response To Indole-3-methanol Cell-cell Junction Organization Glutamate-gated Calcium Ion Channel Activity Cell-cell Junction Cell Surface Receptor Signaling Pathway Postsynaptic Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signaling Cassette Postsynaptic Density Anatomical Structure Morphogenesis Cell Junction Assembly Excitatory Postsynaptic Potential D5 Dopamine Receptor Binding Cell Junction Organization Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Signal Transduction Catenin-TCF7L2 Complex Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Beta-catenin Binding Ligand-gated Monoatomic Ion Channel Activity Anchoring Junction Cellular Response To Oxygen-containing Compound Signal Transduction Cell-cell Adhesion Mediated By Cadherin Ligand-gated Ion Channel Signaling Pathway Rho-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Synaptic Transmission, Glutamatergic Regulation Of Neuroblast Proliferation Presynaptic Membrane Neuroblast Proliferation Intercalated Disc NMDA Glutamate Receptor Activity Glutamate Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission	Catenin Complex Cell-cell Adhesion Mediated By Cadherin Detection Of Muscle Stretch Fascia Adherens Regulation Of Blood Vessel Branching Alpha-catenin Binding Synaptic Vesicle Clustering Adherens Junction Cell-cell Junction Regulation Of Protein Localization Apicolateral Plasma Membrane Response To Muscle Stretch Cadherin Binding Negative Regulation Of Signal Transduction Anchoring Junction Detection Of Mechanical Stimulus Negative Regulation Of Cell Communication Adherens Junction Organization Intercalated Disc Negative Regulation Of Signaling Regulation Of Morphogenesis Of A Branching Structure Phosphatase Binding Regulation Of Transport Cell-cell Adhesion Regulation Of Morphogenesis Of An Epithelium Apical Part Of Cell Regulation Of Neural Precursor Cell Proliferation Protein Phosphatase Binding Regulation Of Intracellular Signal Transduction Glial Cell Differentiation Muscle Cell Differentiation Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Negative Regulation Of Blood Vessel Branching Cell-cell Junction Assembly Stem Cell Population Maintenance Vesicle Localization Detection Of Abiotic Stimulus Maintenance Of Cell Number Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Synaptic Vesicle Clustering Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Negative Regulation Of Vasculature Development Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Scrib-APC-beta-catenin Complex
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