GRIA4 and GRIP1

Number of citations of the paper that reports this interaction (PubMedID 11891216)
0

Data Source:
BioGRID (two hybrid, pull down)

		GRIA4	GRIP1
Description		glutamate ionotropic receptor AMPA type subunit 4	glutamate receptor interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Cell Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Postsynaptic Density Membrane Extracellular Vesicle	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endomembrane System Postsynaptic Density Membrane Dendrite Cytoplasmic Vesicle Cell Projection Neuron Projection Perikaryon Synapse Postsynaptic Membrane
	Molecular Function	Amyloid-beta Binding Glutamate-gated Receptor Activity AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding Beta-catenin Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Monoatomic Ion Transmembrane Transport Negative Regulation Of Smooth Muscle Cell Apoptotic Process Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Regulation Of Presynaptic Membrane Potential	Intracellular Signal Transduction Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Positive Regulation Of Neuron Projection Arborization
Pathways		Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules	Trafficking of GluR2-containing AMPA receptors
Drugs		Glutamic acid Butabarbital Ethanol Talampanel CX-717 Fluciclovine (18F)
Diseases
GWAS		Age at first sexual intercourse ( 27089180 34211149) Glioma ( 34319593) Myopia ( 27182965) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Post bronchodilator FEV1 ( 26634245) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		13 interacting genes: ABHD5 ACTN1 CACNG2 CAMK2G EPB41L1 GRIA1 GRIP1 IQGAP1 PICK1 PRKACA PRKCA PRKCG SDCBP	46 interacting genes: AGAP2 AR BAG4 CARM1 CSPG4 DEPDC1B DZIP3 EEPD1 EFNA5 EFNB1 EFNB2 EP300 ESR1 FGF12 FLII FXR1 FXR2 GPR37 GRIA1 GRIA3 GRIA4 GRIK1 GRIK2 GRIPAP1 GRM2 GRM3 GRM7 H3C1 HUS1 IRF3 KMT5B MFAP3 NCOA6 NEK6 NR3C1 NUMBL PICK1 PPARG PRKD2 PRMT1 RXRA THRA UBE2I VDR WDR6 XDH
Entrez ID		2893	23426
HPRD ID		00694	19086
Ensembl ID		ENSG00000152578	ENSG00000155974
Uniprot IDs		A0A8D9PH77 A0A994J6J2 G3V164 P48058 Q1WWK6	A0A8V8TLS6 Q9Y3R0
PDB IDs			2JIL
Enriched GO Terms of Interacting Partners?		Neuron Projection Endocytic Vesicle Membrane Postsynaptic Density Modulation Of Chemical Synaptic Transmission Synapse Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission Regulation Of Transport Response To Psychosocial Stress Cytosol Long-term Synaptic Potentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell-cell Junction Regulation Of Synaptic Plasticity Plasma Membrane Protein Domain Specific Binding Regulation Of Vesicle-mediated Transport Regulation Of Secretion By Cell Somatodendritic Compartment Response To Morphine Response To Peptide Hormone Long-term Synaptic Depression Response To Toxic Substance Regulation Of Secretion Regulation Of Endocytosis Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Intracellular Signal Transduction Regulation Of Cell Communication Establishment Of Protein Localization Protein Serine/threonine Kinase Activity Regulation Of Biological Quality Regulation Of Signaling AMPA Glutamate Receptor Complex Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Insulin Secretion Protein Localization To Postsynaptic Membrane Intracellular Signaling Cassette Protein Localization To Postsynapse Cell Junction Organization Regulation Of Exocytosis Regulation Of Protein Localization Negative Regulation Of Synaptic Transmission Regulation Of Peptide Hormone Secretion Actin Filament Binding Protein Kinase Activity Establishment Of Protein Localization To Membrane Postsynapse Organization Regulation Of Hormone Levels	Glutamate Receptor Signaling Pathway Regulation Of Cell Communication Glutamate-gated Receptor Activity Nuclear Receptor Activity Presynaptic Membrane Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Signal Transduction Chemical Synaptic Transmission Nuclear Receptor-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Positive Regulation Of Intracellular Signal Transduction Synaptic Signaling Ligand-gated Monoatomic Ion Channel Activity Regulation Of Biological Quality Glutamate Receptor Activity Regulation Of Synaptic Transmission, Glutamatergic Cell-cell Signaling Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Signaling Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synapse Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Transcription Coregulator Binding Cell Communication Hormone-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Nuclear Steroid Receptor Activity Postsynaptic Density Membrane AMPA Glutamate Receptor Activity Retinoic Acid Receptor Signaling Pathway MRNA Transcription Regulation Of Presynaptic Membrane Potential Regulation Of Synaptic Plasticity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Glutamatergic Synapse Regulation Of Signal Transduction Estrogen Response Element Binding
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