GRIA4 and IQGAP1

Number of citations of the paper that reports this interaction (PMID 16190873)
12

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		GRIA4	IQGAP1
Gene Name		glutamate receptor, ionotropic, AMPA 4	IQ motif containing GTPase activating protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell Junction Dendrite Endocytic Vesicle Membrane Vesicle Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Postsynaptic Membrane	Nucleoplasm Cytoplasm Microtubule Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Microtubule Cytoskeleton Lateral Plasma Membrane Cell Junction Axon Growth Cone Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Leading Edge Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Extracellular Vesicular Exosome
	Molecular Function	Ionotropic Glutamate Receptor Activity Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity	GTPase Inhibitor Activity GTPase Activator Activity Ras GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Complex Binding Protein Serine/threonine Kinase Activator Activity Rac GTPase Binding
	Biological Process	Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic	Regulation Of Cytokine Production Energy Reserve Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Ras GTPase Activity Negative Regulation Of Dephosphorylation Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Insulin Secretion Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Glomerular Visceral Epithelial Cell Development Neuron Projection Extension
Pathways		Trafficking of GluR2-containing AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events Activation of AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Transmission across Chemical Synapses	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion Nephrin interactions
Drugs		L-Glutamic Acid
Diseases
GWAS		Refractive error ( 23396134)
Protein-Protein Interactions		12 interactors: ACTN1 CACNG2 CAMK2G EPB41L1 GRIA1 GRIP1 IQGAP1 PICK1 PRKACA PRKCA PRKCG SDCBP	24 interactors: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CLIC5 CLIP1 CTNNB1 CYBB EZR GRIA4 KDR MAPK1 MEN1 NPHS1 PDLIM7 PRKACA RAC1 S100B STAU1 TSG101 YWHAQ
Entrez ID		2893	8826
HPRD ID		00694	04541
Ensembl ID		ENSG00000152578	ENSG00000140575
Uniprot IDs		P48058 Q1WWK6	P46940
PDB IDs			1X0H 2RR8 3FAY 3I6X
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Positive Regulation Of Dense Core Granule Biogenesis Histone H3-T6 Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Signaling Cell Communication Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Activation Of Phospholipase C Activity Platelet Activation Protein Autophosphorylation Positive Regulation Of Phospholipase C Activity Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Lipase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Cell-cell Junction Assembly Cell Surface Receptor Signaling Pathway Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Long Term Synaptic Depression Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Nervous System Development Energy Reserve Metabolic Process Blood Coagulation Positive Regulation Of Blood Vessel Endothelial Cell Migration Hemostasis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Cardiac Muscle Hypertrophy Regulation Of Platelet Activation Rhodopsin Mediated Signaling Pathway	Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cellular Component Organization Epithelium Development Cell Development Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Anatomical Structure Morphogenesis Multicellular Organismal Development Epithelial Cell Development System Development Epithelial Cell Differentiation Tissue Development Cell Differentiation Developmental Process Positive Regulation Of Signal Transduction Organ Development Anatomical Structure Development Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Localization Cell-cell Junction Organization Nervous System Development Regulation Of Cell Proliferation Positive Regulation Of Organelle Organization Regulation Of Cell Differentiation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Osteoblast Differentiation Epidermis Development Apoptotic Process Epidermal Cell Differentiation Organelle Organization Immune System Process Regulation Of Epithelial Cell Proliferation Programmed Cell Death Regulation Of Cytoskeleton Organization Cell Death Death Cell Morphogenesis Response To External Stimulus Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Protein Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Protein Complex Assembly Neuron Differentiation Protein Localization
Tagcloud ?		ae c3h chr directing discharges electroencephalographic frameshift gge handle harbors hej iap inbred mitigating modifier modifiers pcnxl2 profoundly retrotransposition retrotransposon seizing seizures spike substrain substrains surprising swd talen validating	activating binds canonical clinicopathological coexpression correlating cytoplamic cytoplasm dishevelled dvl embryos expressions growths gtpase localization lymph membranous metastase metastases modulator nodal nsclc nucleus poor prognosis resection wnt xenopus
Tagcloud (Difference) ?		ae c3h chr directing discharges electroencephalographic frameshift gge handle harbors hej iap inbred mitigating modifier modifiers pcnxl2 profoundly retrotransposition retrotransposon seizing seizures spike substrain substrains surprising swd talen validating	activating binds canonical clinicopathological coexpression correlating cytoplamic cytoplasm dishevelled dvl embryos expressions growths gtpase localization lymph membranous metastase metastases modulator nodal nsclc nucleus poor prognosis resection wnt xenopus
Tagcloud (Intersection) ?