GRIA4 and CACNG2

Number of citations of the paper that reports this interaction (PMID 11140673)
222

Data Source:
HPRD (in vivo)

		GRIA4	CACNG2
Gene Name		glutamate receptor, ionotropic, AMPA 4	calcium channel, voltage-dependent, gamma subunit 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell Junction Dendrite Endocytic Vesicle Membrane Vesicle Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Postsynaptic Membrane	Plasma Membrane Voltage-gated Calcium Channel Complex Endocytic Vesicle Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex
	Molecular Function	Ionotropic Glutamate Receptor Activity Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity	Voltage-gated Calcium Channel Activity Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic	Transport Synaptic Transmission Neuromuscular Junction Development Transmission Of Nerve Impulse Membrane Depolarization Membrane Hyperpolarization Calcium Ion Transmembrane Transport Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways		Trafficking of GluR2-containing AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events Activation of AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Transmission across Chemical Synapses	Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs		L-Glutamic Acid
Diseases
GWAS		Refractive error ( 23396134)
Protein-Protein Interactions		12 interactors: ACTN1 CACNG2 CAMK2G EPB41L1 GRIA1 GRIP1 IQGAP1 PICK1 PRKACA PRKCA PRKCG SDCBP	10 interactors: APP DLG1 DLG2 DLG3 DLG4 GRIA1 GRIA4 INADL PRKACA SRPK2
Entrez ID		2893	10369
HPRD ID		00694	04220
Ensembl ID		ENSG00000152578
Uniprot IDs		P48058 Q1WWK6	Q9Y698
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Positive Regulation Of Dense Core Granule Biogenesis Histone H3-T6 Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Signaling Cell Communication Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Activation Of Phospholipase C Activity Platelet Activation Protein Autophosphorylation Positive Regulation Of Phospholipase C Activity Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Lipase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Cell-cell Junction Assembly Cell Surface Receptor Signaling Pathway Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Long Term Synaptic Depression Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Nervous System Development Energy Reserve Metabolic Process Blood Coagulation Positive Regulation Of Blood Vessel Endothelial Cell Migration Hemostasis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Cardiac Muscle Hypertrophy Regulation Of Platelet Activation Rhodopsin Mediated Signaling Pathway	Receptor Localization To Synapse Protein Localization To Synapse Synaptic Transmission Receptor Clustering Nucleotide Phosphorylation Cell-cell Signaling Establishment Or Maintenance Of Apical/basal Cell Polarity Signaling Ionotropic Glutamate Receptor Signaling Pathway Cell Communication Phosphorylation Glutamate Receptor Signaling Pathway Chemotaxis Signal Transduction Protein Localization To Membrane Membrane Organization Axon Guidance Cell-cell Junction Assembly Response To Stimulus Phosphate-containing Compound Metabolic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cellular Component Assembly Axonogenesis Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Nucleotide Metabolic Process Axon Development Cortical Cytoskeleton Organization Cell Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Cellular Response To Stimulus Cell-cell Junction Organization Locomotion Neuron Projection Morphogenesis Nucleobase-containing Small Molecule Metabolic Process Nervous System Development Small Molecule Metabolic Process Synaptic Transmission, Glutamatergic Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Learning Or Memory Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Tight Junction Assembly Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Cycle Cognition Negative Regulation Of Catalytic Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis
Tagcloud ?		ae c3h chr directing discharges electroencephalographic frameshift gge handle harbors hej iap inbred mitigating modifier modifiers pcnxl2 profoundly retrotransposition retrotransposon seizing seizures spike substrain substrains surprising swd talen validating	ampa bioinformatics electrophysiological glutamatergic hypomorphic inbred integrative intimately list mapped narrow neuropathic pain1 physiology pinpoint precipitating predisposing predisposition progeny psychosocial qtl rist rpt segregation specifics stargazer stargazin trait ultimately
Tagcloud (Difference) ?		ae c3h chr directing discharges electroencephalographic frameshift gge handle harbors hej iap mitigating modifier modifiers pcnxl2 profoundly retrotransposition retrotransposon seizing seizures spike substrain substrains surprising swd talen validating	ampa bioinformatics electrophysiological glutamatergic hypomorphic integrative intimately list mapped narrow neuropathic pain1 physiology pinpoint precipitating predisposing predisposition progeny psychosocial qtl rist rpt segregation specifics stargazer stargazin trait ultimately
Tagcloud (Intersection) ?		inbred