GRIA4 and PRKCG

Number of citations of the paper that reports this interaction (PubMedID 12471040)
0

Data Source:
HPRD (in vivo, in vitro)

		GRIA4	PRKCG
Description		glutamate ionotropic receptor AMPA type subunit 4	protein kinase C gamma
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Cell Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Postsynaptic Density Membrane Extracellular Vesicle	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Membrane Dendrite Cell Projection Neuron Projection Calyx Of Held Synapse Perinuclear Region Of Cytoplasm Synaptic Membrane Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Amyloid-beta Binding Glutamate-gated Receptor Activity AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Monoatomic Ion Transmembrane Transport Negative Regulation Of Smooth Muscle Cell Apoptotic Process Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Regulation Of Presynaptic Membrane Potential	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Learning Or Memory Chemosensory Behavior Response To Toxic Substance Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Response To Pain Rhythmic Process Regulation Of Phagocytosis Long-term Synaptic Potentiation Innervation Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Via Neuropeptide Negative Regulation Of Proteasomal Protein Catabolic Process Response To Angiotensin Response To Psychosocial Stress Regulation Of Synaptic Vesicle Exocytosis
Pathways		Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules	Calmodulin induced events Disinhibition of SNARE formation Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events WNT5A-dependent internalization of FZD4 Response to elevated platelet cytosolic Ca2+
Drugs		Glutamic acid Butabarbital Ethanol Talampanel CX-717 Fluciclovine (18F)	Tamoxifen Staurosporine Dequalinium Benzoyl peroxide Fostamatinib
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Age at first sexual intercourse ( 27089180 34211149) Glioma ( 34319593) Myopia ( 27182965) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Post bronchodilator FEV1 ( 26634245) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		13 interacting genes: ABHD5 ACTN1 CACNG2 CAMK2G EPB41L1 GRIA1 GRIP1 IQGAP1 PICK1 PRKACA PRKCA PRKCG SDCBP	64 interacting genes: AFAP1 ANXA7 APP ARHGEF25 ARHGEF7 CASR CCHCR1 CD5 CDC42 CHAT CTNNB1 CYTH2 DAB2 DNAJC5 DVL2 EIF4E EPHB1 EXOC5 FBXO7 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 MAPT MARK4 NOXA1 NRGN NUMB PA2G4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 RIGI SCN3A SDC2 SMURF1 STXBP1 TIAM1 TOP2A TRIM5 UBE2T VTN YWHAB YWHAE YWHAG
Entrez ID		2893	5582
HPRD ID		00694	01502
Ensembl ID		ENSG00000152578	ENSG00000126583
Uniprot IDs		A0A8D9PH77 A0A994J6J2 G3V164 P48058 Q1WWK6	A0A804HIU5 B2R5T1 B7Z3W6 P05129
PDB IDs			2E73 2UZP
Enriched GO Terms of Interacting Partners?		Neuron Projection Endocytic Vesicle Membrane Postsynaptic Density Modulation Of Chemical Synaptic Transmission Synapse Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission Regulation Of Transport Response To Psychosocial Stress Cytosol Long-term Synaptic Potentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell-cell Junction Regulation Of Synaptic Plasticity Plasma Membrane Protein Domain Specific Binding Regulation Of Vesicle-mediated Transport Regulation Of Secretion By Cell Somatodendritic Compartment Response To Morphine Response To Peptide Hormone Long-term Synaptic Depression Response To Toxic Substance Regulation Of Secretion Regulation Of Endocytosis Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Intracellular Signal Transduction Regulation Of Cell Communication Establishment Of Protein Localization Protein Serine/threonine Kinase Activity Regulation Of Biological Quality Regulation Of Signaling AMPA Glutamate Receptor Complex Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Insulin Secretion Protein Localization To Postsynaptic Membrane Intracellular Signaling Cassette Protein Localization To Postsynapse Cell Junction Organization Regulation Of Exocytosis Regulation Of Protein Localization Negative Regulation Of Synaptic Transmission Regulation Of Peptide Hormone Secretion Actin Filament Binding Protein Kinase Activity Establishment Of Protein Localization To Membrane Postsynapse Organization Regulation Of Hormone Levels	Cytoplasm Regulation Of Synaptic Plasticity Regulation Of Membrane Potential Postsynapse Regulation Of Cell Communication Regulation Of Signaling Plasma Membrane Cytosol Regulation Of Cell Projection Organization Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Cell-cell Signaling Regulation Of Transport Signaling Cell Junction Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Communication Chemical Synaptic Transmission Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Protein Localization Postsynaptic Membrane Regulation Of Biological Quality Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Focal Adhesion Regulation Of Signal Transduction Neuron Projection Cell Junction Assembly PAR Polarity Complex Protein Kinase C Binding Protein Kinase Binding Regulation Of System Process Positive Regulation Of Synaptic Transmission Positive Regulation Of Cell Communication Positive Regulation Of Signaling NMDA Glutamate Receptor Activity Glutamate Binding Developmental Process Positive Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Regulation Of Neuronal Synaptic Plasticity Anchoring Junction Monoatomic Ion Channel Activity Positive Regulation Of Cellular Component Organization Regulation Of Presynaptic Membrane Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity
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