GRID2 and GRID2IP

Number of citations of the paper that reports this interaction (PubMedID 11826110)
67

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		GRID2	GRID2IP
Description		glutamate ionotropic receptor delta type subunit 2	Grid2 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Ionotropic Glutamate Receptor Complex Membrane AMPA Glutamate Receptor Complex Somatodendritic Compartment Dendritic Spine Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Trans-synaptic Protein Complex Postsynaptic Density Membrane Glutamatergic Synapse	Plasma Membrane Membrane Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component Cerebellar Granule Cell To Purkinje Cell Synapse
	Molecular Function	AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity PDZ Domain Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Scaffold Protein Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Glutamate Receptor Signaling Pathway Intracellular Protein Localization Regulation Of Neuron Projection Development Cerebellar Granule Cell Differentiation Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Neuron Apoptotic Process Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Assembly Positive Regulation Of Synapse Assembly Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Prepulse Inhibition Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Postsynaptic Density Assembly Synaptic Signaling Via Neuropeptide Positive Regulation Of Long-term Synaptic Depression Excitatory Synapse Assembly Regulation Of Presynapse Assembly	Long-term Synaptic Depression Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Pathways
Drugs
Diseases
GWAS		Coffee consumption ( 31046077) Intelligence (MTAG) ( 29326435) Manganese levels ( 26025379) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 30456828) Obsessive-compulsive traits ( 33531474) Pancreatic beta-cell glucose sensitivity ( 32944759) Post bronchodilator FEV1/FVC ratio ( 26634245) Smoking initiation ( 33082346)	Body mass index ( 26426971) Heel bone mineral density x serum urate levels interaction ( 34046847) Inflammatory bowel disease ( 28067908) Irritable bowel syndrome ( 25248455) Ulcerative colitis ( 28067908)
Interacting Genes		10 interacting genes: AP4M1 DLG2 EML1 GOPC GRIA1 GRID2IP GRIK2 GRIK5 MAGI2 PTPN4	2 interacting genes: GRID2 RPS6KA1
Entrez ID		2895	392862
HPRD ID		06781	19587
Ensembl ID		ENSG00000152208	ENSG00000215045
Uniprot IDs		O43424	A4D2P6 C9J5F6
PDB IDs		5KC8 5KCA
Enriched GO Terms of Interacting Partners?		Glutamate-gated Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Postsynaptic Density Synapse Postsynaptic Density Membrane Regulation Of Presynaptic Membrane Potential Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Negative Regulation Of Synaptic Transmission Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Complex Receptor Clustering Glutamate Receptor Signaling Pathway Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Localization Within Membrane Glutamate Receptor Binding Postsynaptic Membrane Glutamate-gated Calcium Ion Channel Activity Protein Localization To Membrane Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Trans-synaptic Signaling Synaptic Signaling Long-term Synaptic Depression Postsynaptic Density, Intracellular Component Presynaptic Membrane Dendrite Monoatomic Ion Channel Activity Modulation Of Chemical Synaptic Transmission Neuronal Action Potential Regulation Of Synaptic Plasticity Cell-cell Signaling Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Hippocampal Mossy Fiber To CA3 Synapse Signaling Modulation Of Excitatory Postsynaptic Potential Cell Communication Cell Projection Signaling Receptor Activity Mossy Fiber Rosette Detection Of Cold Stimulus Involved In Thermoception Excitatory Postsynaptic Potential Extracellularly Glutamate-gated Ion Channel Activity Negative Regulation Of Anion Channel Activity Plasma Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Cerebellar Granule Cell Differentiation Positive Regulation Of Long-term Synaptic Depression AMPA Glutamate Receptor Activity Ionotropic Glutamate Receptor Complex Trans-synaptic Signaling Trans-synaptic Protein Complex Synaptic Signaling Chemical Synaptic Transmission Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation Ribosomal Protein S6 Kinase Activity Synaptic Signaling Via Neuropeptide Cell-cell Signaling Excitatory Synapse Assembly Signaling Cell Communication Glutamate Receptor Activity Prepulse Inhibition Regulation Of Long-term Synaptic Depression Glutamatergic Neuron Differentiation Regulation Of Postsynaptic Density Assembly Somatodendritic Compartment Regulation Of Postsynaptic Specialization Assembly Cell Differentiation In Hindbrain Parallel Fiber To Purkinje Cell Synapse Regulation Of Excitatory Synapse Assembly Regulation Of Translation In Response To Stress Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Synapse AMPA Glutamate Receptor Complex Protein Serine/threonine/tyrosine Kinase Activity Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synaptic Transmission, Glutamatergic Glutamate Receptor Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Synapse Assembly Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Excitatory Postsynaptic Potential TORC1 Signaling Scaffold Protein Binding Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Multicellular Organismal Process PDZ Domain Binding TOR Signaling
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