GRID2 and GRIK5

Number of citations of the paper that reports this interaction (PMID 12573530)
7

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GRID2	GRIK5
Gene Name		glutamate receptor, ionotropic, delta 2	glutamate receptor, ionotropic, kainate 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Ionotropic Glutamate Receptor Complex Cell Junction Dendrite Dendritic Spine Synapse Postsynaptic Membrane	Endoplasmic Reticulum Plasma Membrane Postsynaptic Density Cell Junction Dendrite Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane
	Molecular Function	Ionotropic Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Glutamate Receptor Activity PDZ Domain Binding Scaffold Protein Binding	Extracellular-glutamate-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity SH3 Domain Binding PDZ Domain Binding Identical Protein Binding
	Biological Process	Transport Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Glutamate Receptor Signaling Pathway Regulation Of Neuron Projection Development Cerebellar Granule Cell Differentiation Ion Transmembrane Transport Cellular Protein Localization Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Neuron Apoptotic Process Regulation Of Excitatory Postsynaptic Membrane Potential Prepulse Inhibition	Protein Retention In ER Lumen Synaptic Transmission Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Establishment Of Localization In Cell Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Response To Glucose Stimulus
Pathways			Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs			L-Glutamic Acid
Diseases
GWAS		Obesity-related traits ( 23251661)	Bipolar disorder ( 21771265)
Protein-Protein Interactions		10 interactors: AP4M1 DLG2 EML1 GOPC GRIA1 GRID2IP GRIK2 GRIK5 MAGI2 PTPN4	8 interactors: DLG4 GOLM1 GPAA1 GRID2 GRIK2 GRIK3 LRSAM1 MLF1
Entrez ID		2895	2901
HPRD ID		06781	02614
Ensembl ID		ENSG00000152208	ENSG00000105737
Uniprot IDs		E9PH24 O43424	Q16478
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Clustering Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Neuron-neuron Synaptic Transmission Regulation Of Synaptic Transmission Cellular Protein Localization Protein Retention In ER Lumen Maintenance Of Protein Localization In Endoplasmic Reticulum Protein Localization To Membrane Regulation Of Vesicle-mediated Transport Long Term Synaptic Depression Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Regulation Of Synaptic Plasticity Protein Localization Synaptic Transmission Regulation Of Synaptic Vesicle Exocytosis Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Transport Cellular Localization Positive Regulation Of Neuron Apoptotic Process Membrane Organization Cellular Response To Glucose Stimulus Regulation Of Neurotransmitter Secretion Cell-cell Signaling Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Neuron Death Regulation Of Postsynaptic Membrane Potential Cytoplasmic Sequestering Of CFTR Protein Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Regulation Of Phosphatase Activity Planar Cell Polarity Pathway Involved In Axis Elongation Negative Regulation Of Signaling Membrane Depolarization Protein Localization To Endoplasmic Reticulum Regulation Of Dephosphorylation Response To Glucose Regulation Of Exocytosis Intracellular Transport Cytoplasmic Transport Response To Carbohydrate Negative Regulation Of Golgi To Plasma Membrane Protein Transport Glucose Homeostasis	Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Regulation Of Membrane Potential Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Protein Retention In ER Lumen Maintenance Of Protein Localization In Endoplasmic Reticulum Membrane Depolarization Negative Regulation Of Synaptic Transmission, Glutamatergic Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Endocytosis Regulation Of Synaptic Transmission Receptor Clustering Cell-cell Signaling Regulation Of Neuronal Synaptic Plasticity Protein Localization Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Vesicle-mediated Transport Ubiquitin-dependent Endocytosis Positive Regulation Of Synaptic Transmission Cellular Protein Localization Protein Localization To Endoplasmic Reticulum Neuromuscular Process Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Regulation Of Synaptic Plasticity Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Endocytosis Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Vesicle Organization Maintenance Of Apical/basal Cell Polarity Membrane Organization Regulation Of Cellular Component Organization Receptor Localization To Synapse Regulation Of Neuron Apoptotic Process Negative Regulation Of Receptor Internalization Viral Budding Myeloid Progenitor Cell Differentiation Locomotory Exploration Behavior Dendritic Spine Morphogenesis Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Neuron Death Synaptic Vesicle Maturation
Tagcloud ?		4q ataxia atrophy biallelic cerebella cerebellar cerebellum deletions evolutionarily exon eye fibers genotyping heterozygous homozygosity homozygous linkage movement movements ortholog purkinje recordings resemblance sanger speech spines synapse tonic upgaze	abuse bdkrb2 bipolar compulsive confer defines difficulty disorders eating genetics ghrh hint ionotropic kainate neurodevelopment neurotransmission obsessive odd panic preb prolactin psychiatric psychotic releasing rs945032 snps substance susceptibility synonymous
Tagcloud (Difference) ?		4q ataxia atrophy biallelic cerebella cerebellar cerebellum deletions evolutionarily exon eye fibers genotyping heterozygous homozygosity homozygous linkage movement movements ortholog purkinje recordings resemblance sanger speech spines synapse tonic upgaze	abuse bdkrb2 bipolar compulsive confer defines difficulty disorders eating genetics ghrh hint ionotropic kainate neurodevelopment neurotransmission obsessive odd panic preb prolactin psychiatric psychotic releasing rs945032 snps substance susceptibility synonymous
Tagcloud (Intersection) ?