GRID2 and GRIK5

Number of citations of the paper that reports this interaction (PubMedID 12573530)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GRID2	GRIK5
Description		glutamate ionotropic receptor delta type subunit 2	glutamate ionotropic receptor kainate type subunit 5
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Ionotropic Glutamate Receptor Complex Membrane AMPA Glutamate Receptor Complex Somatodendritic Compartment Dendritic Spine Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Trans-synaptic Protein Complex Postsynaptic Density Membrane Glutamatergic Synapse	Nucleoplasm Endoplasmic Reticulum Plasma Membrane Membrane Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane
	Molecular Function	AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity PDZ Domain Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Scaffold Protein Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Glutamate-gated Receptor Activity Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Glutamate Receptor Signaling Pathway Intracellular Protein Localization Regulation Of Neuron Projection Development Cerebellar Granule Cell Differentiation Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Neuron Apoptotic Process Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Assembly Positive Regulation Of Synapse Assembly Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Prepulse Inhibition Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Postsynaptic Density Assembly Synaptic Signaling Via Neuropeptide Positive Regulation Of Long-term Synaptic Depression Excitatory Synapse Assembly Regulation Of Presynapse Assembly	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Modulation Of Chemical Synaptic Transmission Excitatory Postsynaptic Potential Regulation Of Presynaptic Membrane Potential
Pathways			Activation of Ca-permeable Kainate Receptor
Drugs			Glutamic acid Butabarbital Topiramate
Diseases
GWAS		Coffee consumption ( 31046077) Intelligence (MTAG) ( 29326435) Manganese levels ( 26025379) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 30456828) Obsessive-compulsive traits ( 33531474) Pancreatic beta-cell glucose sensitivity ( 32944759) Post bronchodilator FEV1/FVC ratio ( 26634245) Smoking initiation ( 33082346)	Bipolar disorder ( 21771265) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte count ( 32888494) Meat-related diet ( 32066663)
Interacting Genes		10 interacting genes: AP4M1 DLG2 EML1 GOPC GRIA1 GRID2IP GRIK2 GRIK5 MAGI2 PTPN4	9 interacting genes: DLG4 GOLM1 GPAA1 GRID2 GRIK1 GRIK2 GRIK3 LRSAM1 MLF1
Entrez ID		2895	2901
HPRD ID		06781	02614
Ensembl ID		ENSG00000152208	ENSG00000105737
Uniprot IDs		O43424	Q16478
PDB IDs		5KC8 5KCA
Enriched GO Terms of Interacting Partners?		Glutamate-gated Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Postsynaptic Density Synapse Postsynaptic Density Membrane Regulation Of Presynaptic Membrane Potential Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Negative Regulation Of Synaptic Transmission Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Complex Receptor Clustering Glutamate Receptor Signaling Pathway Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Localization Within Membrane Glutamate Receptor Binding Postsynaptic Membrane Glutamate-gated Calcium Ion Channel Activity Protein Localization To Membrane Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Trans-synaptic Signaling Synaptic Signaling Long-term Synaptic Depression Postsynaptic Density, Intracellular Component Presynaptic Membrane Dendrite Monoatomic Ion Channel Activity Modulation Of Chemical Synaptic Transmission Neuronal Action Potential Regulation Of Synaptic Plasticity Cell-cell Signaling Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Hippocampal Mossy Fiber To CA3 Synapse Signaling Modulation Of Excitatory Postsynaptic Potential Cell Communication Cell Projection Signaling Receptor Activity Mossy Fiber Rosette Detection Of Cold Stimulus Involved In Thermoception Excitatory Postsynaptic Potential Extracellularly Glutamate-gated Ion Channel Activity Negative Regulation Of Anion Channel Activity Plasma Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Glutamate Receptor Signaling Pathway Postsynaptic Density Membrane Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Glutamate-gated Calcium Ion Channel Activity Glutamate-gated Receptor Activity Glutamate Receptor Activity Postsynaptic Membrane Regulation Of Postsynaptic Membrane Potential Chemical Synaptic Transmission Dendrite Cytoplasm Trans-synaptic Signaling Synaptic Signaling Monoatomic Ion Channel Activity Regulation Of Membrane Potential Ionotropic Glutamate Receptor Complex Modulation Of Chemical Synaptic Transmission Scaffold Protein Binding Cell-cell Signaling Regulation Of Synaptic Transmission, Glutamatergic Signaling Receptor Activity Signaling PDZ Domain Binding Negative Regulation Of Synaptic Transmission, Glutamatergic Cell Communication Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Presynaptic Membrane Synapse Calcium-mediated Signaling Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Complex Regulation Of Presynaptic Membrane Potential Glutamatergic Synapse Regulation Of Synaptic Plasticity Negative Regulation Of Synaptic Transmission Terminal Bouton Modulation Of Excitatory Postsynaptic Potential Receptor Clustering Monoatomic Ion Transmembrane Transport Regulation Of Neuronal Synaptic Plasticity Excitatory Postsynaptic Potential P2Y1 Nucleotide Receptor Binding Mossy Fiber Rosette Detection Of Cold Stimulus Involved In Thermoception Extracellularly Glutamate-gated Ion Channel Activity
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