GRID2 and EML1

Number of citations: 0 (PubMedID 11829466)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		GRID2	EML1
Name		glutamate ionotropic receptor delta type subunit 2	EMAP like 1
Structure
GO Annotations	Cellular Component	Plasma Membrane Ionotropic Glutamate Receptor Complex Membrane AMPA Glutamate Receptor Complex Somatodendritic Compartment Dendritic Spine Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Trans-synaptic Protein Complex Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Mitotic Spindle Mitotic Spindle Pole Mitotic Spindle Midzone
	Molecular Function	AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity PDZ Domain Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Scaffold Protein Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Calcium Ion Binding Protein Binding Microtubule Binding Tubulin Binding
	Biological Process	Monoatomic Ion Transport Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Glutamate Receptor Signaling Pathway Intracellular Protein Localization Regulation Of Neuron Projection Development Cerebellar Granule Cell Differentiation Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Neuron Apoptotic Process Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Assembly Positive Regulation Of Synapse Assembly Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Prepulse Inhibition Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Postsynaptic Density Assembly Synaptic Signaling Via Neuropeptide Positive Regulation Of Long-term Synaptic Depression Excitatory Synapse Assembly Regulation Of Presynapse Assembly	Microtubule Cytoskeleton Organization Hematopoietic Progenitor Cell Differentiation Mitotic Spindle Organization Neuroblast Proliferation Brain Development
GWAS		Coffee consumption ( 31046077 ) Intelligence (MTAG) ( 29326435 ) Manganese levels ( 26025379 ) Metabolite levels ( 23823483 ) Obesity-related traits ( 23251661 ) Obsessive-compulsive disorder ( 30456828 ) Obsessive-compulsive traits ( 33531474 ) Pancreatic beta-cell glucose sensitivity ( 32944759 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Smoking initiation ( 33082346 )	Appendicular lean mass ( 33097823 ) Brain morphology (MOSTest) ( 32665545 ) Coronary artery disease ( 29212778 ) Depression in smokers ( 30219690 ) Pulse pressure ( 27841878 ) Scalp hair shape ( 26926045 ) Visceral fat ( 30942860 )
Novel Interactors		None recorded	2 novel interactors: CKB GRIN2A
Interacting Genes		10 interacting genes: AP4M1 DLG2 EML1 GOPC GRIA1 GRID2IP GRIK2 GRIK5 MAGI2 PTPN4	7 interacting genes: GRID1 GRID2 ISG20L2 MTDH PTEN TUBA1A UBE3A
Entrez ID		2895	2009
HPRD ID		06781	03613
Ensembl ID		ENSG00000152208	ENSG00000066629
Uniprot IDs		O43424	O00423
PDB IDs		5KC8 5KCA	4CI8
GO Terms Enriched among Interactors		Glutamate-gated Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Postsynaptic Density Synapse Postsynaptic Density Membrane Regulation Of Presynaptic Membrane Potential Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Negative Regulation Of Synaptic Transmission Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Complex Receptor Clustering Glutamate Receptor Signaling Pathway Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Localization Within Membrane Glutamate Receptor Binding Postsynaptic Membrane Glutamate-gated Calcium Ion Channel Activity Protein Localization To Membrane Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Trans-synaptic Signaling Synaptic Signaling Long-term Synaptic Depression Postsynaptic Density, Intracellular Component Presynaptic Membrane Dendrite Monoatomic Ion Channel Activity Modulation Of Chemical Synaptic Transmission Neuronal Action Potential Regulation Of Synaptic Plasticity Cell-cell Signaling Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Hippocampal Mossy Fiber To CA3 Synapse Signaling Modulation Of Excitatory Postsynaptic Potential Cell Communication Cell Projection Signaling Receptor Activity Mossy Fiber Rosette Detection Of Cold Stimulus Involved In Thermoception Excitatory Postsynaptic Potential Extracellularly Glutamate-gated Ion Channel Activity Negative Regulation Of Anion Channel Activity Plasma Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Dendritic Spine Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Trans-synaptic Protein Complex AMPA Glutamate Receptor Activity Synaptic Signaling Via Neuropeptide Forebrain Morphogenesis Chemical Synaptic Transmission Trans-synaptic Signaling Regulation Of Postsynaptic Membrane Potential Postsynaptic Density Membrane Synaptic Signaling Prepulse Inhibition Startle Response Synapse Regulation Of Membrane Potential Monoatomic Ion Channel Activity Dentate Gyrus Development AMPA Glutamate Receptor Complex Glutamatergic Synapse Positive Regulation Of Excitatory Postsynaptic Potential Cell-cell Signaling Signaling Postsynaptic Membrane Cell Communication Synapse Organization Modulation Of Excitatory Postsynaptic Potential Signaling Receptor Activity Learning Or Memory Social Behavior Visual Learning Regulation Of Synapse Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Excitatory Postsynaptic Potential Visual Behavior Cognition Negative Regulation Of Synaptic Vesicle Clustering Sperm Entry Positive Regulation Of Golgi Lumen Acidification Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels PDZ Domain Binding Futile Creatine Cycle Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration