GRID2 and PTPN4

Number of citations of the paper that reports this interaction (PMID 10748123)
8

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		GRID2	PTPN4
Gene Name		glutamate receptor, ionotropic, delta 2	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Ionotropic Glutamate Receptor Complex Cell Junction Dendrite Dendritic Spine Synapse Postsynaptic Membrane	Cytoplasm Cytoskeleton Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Ionotropic Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Glutamate Receptor Activity PDZ Domain Binding Scaffold Protein Binding	Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding
	Biological Process	Transport Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Glutamate Receptor Signaling Pathway Regulation Of Neuron Projection Development Cerebellar Granule Cell Differentiation Ion Transmembrane Transport Cellular Protein Localization Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Neuron Apoptotic Process Regulation Of Excitatory Postsynaptic Membrane Potential Prepulse Inhibition	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways
Drugs			Alendronate
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		10 interactors: AP4M1 DLG2 EML1 GOPC GRIA1 GRID2IP GRIK2 GRIK5 MAGI2 PTPN4	11 interactors: ATRX CRK EEF1A1 EEF1G GRID2 GRIN2A KAT5 LPL PRSS1 TK1 ZZEF1
Entrez ID		2895	5775
HPRD ID		06781	01471
Ensembl ID		ENSG00000152208	ENSG00000088179
Uniprot IDs		E9PH24 O43424	P29074
PDB IDs			2CS5 2I75 2VPH 3NFK 3NFL
Enriched GO Terms of Interacting Partners?		Receptor Clustering Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Neuron-neuron Synaptic Transmission Regulation Of Synaptic Transmission Cellular Protein Localization Protein Retention In ER Lumen Maintenance Of Protein Localization In Endoplasmic Reticulum Protein Localization To Membrane Regulation Of Vesicle-mediated Transport Long Term Synaptic Depression Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Regulation Of Synaptic Plasticity Protein Localization Synaptic Transmission Regulation Of Synaptic Vesicle Exocytosis Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Transport Cellular Localization Positive Regulation Of Neuron Apoptotic Process Membrane Organization Cellular Response To Glucose Stimulus Regulation Of Neurotransmitter Secretion Cell-cell Signaling Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Neuron Death Regulation Of Postsynaptic Membrane Potential Cytoplasmic Sequestering Of CFTR Protein Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Regulation Of Phosphatase Activity Planar Cell Polarity Pathway Involved In Axis Elongation Negative Regulation Of Signaling Membrane Depolarization Protein Localization To Endoplasmic Reticulum Regulation Of Dephosphorylation Response To Glucose Regulation Of Exocytosis Intracellular Transport Cytoplasmic Transport Response To Carbohydrate Negative Regulation Of Golgi To Plasma Membrane Protein Transport Glucose Homeostasis	Startle Response Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Response To Organic Substance Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Fetal Process Involved In Parturition Negative Regulation Of Telomeric RNA Transcription From RNA Pol II Promoter Regulation Of Postsynaptic Membrane Potential Response To External Stimulus Response To Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Response To Radiation Skeletal Muscle Cell Proliferation Signal Transduction By P53 Class Mediator Membrane Depolarization Chylomicron Remodeling Cellular Response To Hydroxyurea Neuromuscular Process Directional Locomotion Positive Regulation Of Nuclear Cell Cycle DNA Replication Translational Elongation Response To Cortisol Thymidine Metabolic Process Positive Regulation Of Sequestering Of Triglyceride Deoxyribonucleoside Monophosphate Biosynthetic Process Very-low-density Lipoprotein Particle Remodeling Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Triglyceride-rich Lipoprotein Particle Remodeling Cerebellar Granule Cell Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Regulation Of Membrane Potential DNA Damage Response, Signal Transduction Resulting In Transcription Response To Hormone Heterocycle Metabolic Process Prepulse Inhibition Serotonin Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stimulus Biosynthetic Process Replication Fork Processing Sleep Positive Regulation Of DNA-dependent DNA Replication Cerebellar Granular Layer Morphogenesis Parturition
Tagcloud ?		4q ataxia atrophy biallelic cerebella cerebellar cerebellum deletions evolutionarily exon eye fibers genotyping heterozygous homozygosity homozygous linkage movement movements ortholog purkinje recordings resemblance sanger speech spines synapse tonic upgaze	abrogates adopts analytical angle catalytic communication compact competence conformation disrupting emerging encompassing interdomain mere nmr notion pdz phosphatase physiologically players predominant prevents ray regulators restores scattering strengthens triggers ultracentrifugation
Tagcloud (Difference) ?		4q ataxia atrophy biallelic cerebella cerebellar cerebellum deletions evolutionarily exon eye fibers genotyping heterozygous homozygosity homozygous linkage movement movements ortholog purkinje recordings resemblance sanger speech spines synapse tonic upgaze	abrogates adopts analytical angle catalytic communication compact competence conformation disrupting emerging encompassing interdomain mere nmr notion pdz phosphatase physiologically players predominant prevents ray regulators restores scattering strengthens triggers ultracentrifugation
Tagcloud (Intersection) ?