GPX4 and MAPK13

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GPX4	MAPK13
Gene Name		glutathione peroxidase 4	mitogen-activated protein kinase 13
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Extracellular Vesicular Exosome	Cytosol
	Molecular Function	Glutathione Peroxidase Activity Selenium Binding Glutathione Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	Phospholipid Metabolic Process Glutathione Metabolic Process Response To Oxidative Stress Multicellular Organismal Development Aging Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Estradiol Hydrogen Peroxide Catabolic Process Small Molecule Metabolic Process Regulation Of Inflammatory Response Oxidation-reduction Process	MAPK Cascade Transcription, DNA-templated Regulation Of Transcription, DNA-templated Response To Stress Response To Osmotic Stress Cell Cycle Ras Protein Signal Transduction Peptidyl-serine Phosphorylation Positive Regulation Of Interleukin-6 Production Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Inflammatory Response
Pathways		Arachidonic acid metabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives	Signalling to ERKs Signalling by NGF DSCAM interactions Signaling by VEGF Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Signalling to RAS p38MAPK events NGF signalling via TRKA from the plasma membrane VEGFA-VEGFR2 Pathway Innate Immune System
Drugs		Glutathione
Diseases
GWAS		Crohn's disease ( 21102463 23128233)
Protein-Protein Interactions		2 interactors: MAPK13 PRDX6	15 interactors: AKIP1 ANKLE2 APP ATF2 EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4
Entrez ID		2879	5603
HPRD ID		11819	09113
Ensembl ID		ENSG00000167468	ENSG00000156711
Uniprot IDs		P36969	O15264
PDB IDs		2GS3 2OBI	3COI 4EXU 4EYJ 4EYM
Enriched GO Terms of Interacting Partners?			MAPK Cascade Signal Transduction By Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Adult Locomotory Behavior Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Activation Of MAPK Activity Regulation Of Protein Phosphorylation Adult Behavior Toll-like Receptor 5 Signaling Pathway Developmental Process Toll-like Receptor 10 Signaling Pathway Phosphorylation Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Response To Stress Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of MAP Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta2 Production MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Protein Modification Process Locomotory Behavior MyD88-dependent Toll-like Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Toll-like Receptor 4 Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Toll-like Receptor Signaling Pathway Response To Organic Substance Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Signaling Positive Regulation Of Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cell Communication Regulation Of Kinase Activity
Tagcloud ?		biopsies chc cohorts drive eliminates elimination eradication fusogenic glutathione hcv hepatocarcinogenesis hepatocellular infectivity lipoproteins liposome modulating ns5a peroxidase peroxide peroxides phosphatidylinositol regimens replicative returned ros scavenger scavengers tightly virions	alpha3 alpha3beta bap calcification calcifying ccl22 cd14 cd16 cd45 chi3l1 chit1 chitinase diaphyseal distinguished drilled femurs freshly fulfill gpnmb hole implanted ll monocytes monoosteophil monoosteophils osteoactivin osteopontin p38mapkdelta spp1
Tagcloud (Difference) ?		biopsies chc cohorts drive eliminates elimination eradication fusogenic glutathione hcv hepatocarcinogenesis hepatocellular infectivity lipoproteins liposome modulating ns5a peroxidase peroxide peroxides phosphatidylinositol regimens replicative returned ros scavenger scavengers tightly virions	alpha3 alpha3beta bap calcification calcifying ccl22 cd14 cd16 cd45 chi3l1 chit1 chitinase diaphyseal distinguished drilled femurs freshly fulfill gpnmb hole implanted ll monocytes monoosteophil monoosteophils osteoactivin osteopontin p38mapkdelta spp1
Tagcloud (Intersection) ?