GPX4 and GTF2F1

		GPX4	GTF2F1
Description		glutathione peroxidase 4	general transcription factor IIF subunit 1
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Mitochondrion Cytosol Protein-containing Complex Extracellular Exosome	Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIF Complex Cell Junction Protein-containing Complex
	Molecular Function	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Selenium Binding Oxidoreductase Activity Identical Protein Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity	RNA Polymerase II General Transcription Initiation Factor Binding TFIIF-class Transcription Factor Complex Binding DNA Binding RNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Phosphatase Activator Activity Protein Phosphatase Binding Protein Domain Specific Binding Promoter-specific Chromatin Binding
	Biological Process	Chromatin Organization Lipid Metabolic Process Phospholipid Metabolic Process Apoptotic Process Response To Oxidative Stress Spermatogenesis Dendrite Development Arachidonate Metabolic Process Lipoxygenase Pathway Cerebellum Development Response To Estradiol Response To Lipopolysaccharide Multicellular Organism Growth Long-chain Fatty Acid Biosynthetic Process Protein Polymerization Cellular Oxidant Detoxification Negative Regulation Of Ferroptosis	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Response To Virus Negative Regulation Of Protein Binding Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression
Drugs		Glutathione Glutathione Glutathione disulfide Benzoyl peroxide
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 31174203) Crohn's disease ( 23128233 21102463 28067908) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) hemolysis of donated blood (oxidative) ( 34014839) Inflammatory bowel disease ( 28067908) Keratinocyte cancer (MTAG) ( 31174203) Liver enzyme levels (alkaline phosphatase) ( 33972514) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: MAPK13 PARK7 PRDX6 RNF31 SNRNP48	34 interacting genes: ABL1 AHR AR ARNT ATF7IP BCL2L13 CCNT1 CDK9 CEBPA CFTR CSNK2A1 CTDP1 CTDSP1 DAPK1 FEZ1 FNDC3B FOS GTF2A1 GTF2B GTF2E1 GTF2E2 GTF2F2 GTF2H4 JUN MAGEC1 MSX2 MYC PARP1 PSMC2 PTN SRF TAF1 TAF11 TRIM27
Entrez ID		2879	2962
HPRD ID		11819	01803
Ensembl ID		ENSG00000167468	ENSG00000125651
Uniprot IDs		P36969 Q6PI42	P35269
PDB IDs		2GS3 2OBI 5H5Q 5H5R 5H5S 6ELW 6HKQ 6HN3 7L8K 7L8L 7L8M 7L8Q 7L8R 7U4I 7U4J 7U4K 7U4L 7U4M 7U4N 8Q8J 8Q8N	1F3U 1I27 1J2X 1NHA 1ONV 2K7L 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWD 7ZX7 7ZX8 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8S51 8S52 8S54 8S55 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS 8WAT 8WAU 8WAV 8WAW 8WAX 8WAY 8WAZ 8WB0
Enriched GO Terms of Interacting Partners?		Peroxiredoxin Activity Transferase Activity Guanidinoacetate N-methyltransferase Activity Hydrogen Peroxide Metabolic Process Glyoxal Catabolic Process L-dopa Decarboxylase Activator Activity Guanine Deglycation Protein Deglycase Activity Glyoxalase (glycolic Acid-forming) Activity Glycolate Biosynthetic Process Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Detoxification Of Mercury Ion Negative Regulation Of Death-inducing Signaling Complex Assembly Cellular Response To Glyoxal Glyoxal Metabolic Process Positive Regulation Of L-dopa Biosynthetic Process Tyrosine 3-monooxygenase Activator Activity 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase Activity Creatine Biosynthetic Process TFIIF-class Transcription Factor Complex Binding Transcription Factor TFIIF Complex Cellular Response To Sorbitol Cellular Response To Hydrogen Peroxide Cellular Oxidant Detoxification Negative Regulation Of Protein K48-linked Deubiquitination Detection Of Oxidative Stress Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Dopamine Biosynthetic Process Creatine Metabolic Process Cellular Response To Anisomycin Response To Oxidative Stress Reactive Oxygen Species Metabolic Process Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Superoxide Dismutase Copper Chaperone Activity Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Glycolate Metabolic Process Detoxification Of Hydrogen Peroxide Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of TRAIL Production Mercury Ion Binding Linear Polyubiquitin Binding Response To Hydrogen Peroxide Response To Anisomycin Cellular Response To Reactive Oxygen Species Response To Sorbitol Cellular Detoxification Cellular Detoxification Of Methylglyoxal Methylglyoxal Catabolic Process To Lactate	Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase II General Transcription Initiation Factor Activity Transcription Initiation At RNA Polymerase II Promoter Nucleobase-containing Compound Biosynthetic Process Transcription Factor TFIID Complex DNA-templated Transcription Initiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II RNA Metabolic Process Nucleus Positive Regulation Of DNA-templated Transcription Initiation Nucleoplasm Host-mediated Activation Of Viral Transcription Regulation Of DNA-templated Transcription Initiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Macromolecule Biosynthetic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Nucleic Acid Metabolic Process TBP-class Protein Binding Positive Regulation Of RNA Metabolic Process DNA Binding Host-mediated Perturbation Of Viral Transcription Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Host-mediated Activation Of Viral Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Positive Regulation Of MiRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Metabolic Process RNA Polymerase II General Transcription Initiation Factor Binding RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of MiRNA Transcription Host-mediated Perturbation Of Viral Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription
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