GPX4 and APBA3

Data Source: HiPPIP (Novel)

		GPX4	APBA3
Name		glutathione peroxidase 4	amyloid beta precursor protein binding family A member 3
Structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Mitochondrion Cytosol Protein-containing Complex Extracellular Exosome	Cytoplasm Plasma Membrane Dendritic Spine Perinuclear Region Of Cytoplasm
	Molecular Function	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Selenium Binding Oxidoreductase Activity Identical Protein Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity	Amyloid-beta Binding Enzyme Inhibitor Activity Protein Binding Enzyme Binding
	Biological Process	Chromatin Organization Lipid Metabolic Process Phospholipid Metabolic Process Apoptotic Process Response To Oxidative Stress Spermatogenesis Dendrite Development Arachidonate Metabolic Process Lipoxygenase Pathway Cerebellum Development Response To Estradiol Response To Lipopolysaccharide Multicellular Organism Growth Long-chain Fatty Acid Biosynthetic Process Protein Polymerization Cellular Oxidant Detoxification Negative Regulation Of Ferroptosis	In Utero Embryonic Development Chemical Synaptic Transmission Regulation Of Gene Expression Protein Transport Negative Regulation Of Catalytic Activity
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives	Neurexins and neuroligins
Drugs		Glutathione Glutathione Glutathione disulfide Benzoyl peroxide	None
GWAS		Advanced age-related macular degeneration ( 26691988 ) Asthma (childhood onset) ( 31036433 ) Basal cell carcinoma ( 31174203 ) Crohn's disease ( 23128233 21102463 28067908 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) hemolysis of donated blood (oxidative) ( 34014839 ) Inflammatory bowel disease ( 28067908 ) Keratinocyte cancer (MTAG) ( 31174203 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Nasal polyps ( 30643255 ) Neutrophil percentage of granulocytes ( 27863252 ) Sum eosinophil basophil counts ( 27863252 ) White blood cell count ( 32888494 )	Serum alkaline phosphatase levels ( 33547301 )
Novel Interactors		7 novel interactors: APBA3 EGR4 FUT5 GAMT GTF2F1 MATK ZNF197	2 novel interactors: BDNF GPX4
Interacting Genes		5 interacting genes: MAPK13 PARK7 PRDX6 RNF31 SNRNP48	8 interacting genes: APP ARF3 ARF4 AZI2 BCR EGFR TANK TBKBP1
Entrez ID		2879	9546
HPRD ID		11819	05038
Ensembl ID		ENSG00000167468	ENSG00000011132
Uniprot IDs		P36969 Q6PI42	O96018
PDB IDs		2GS3 2OBI 5H5Q 5H5R 5H5S 6ELW 6HKQ 6HN3 7L8K 7L8L 7L8M 7L8Q 7L8R 7U4I 7U4J 7U4K 7U4L 7U4M 7U4N 8Q8J 8Q8N	2YT7 2YT8 5UWS
GO Terms Enriched among Interactors		Peroxiredoxin Activity Transferase Activity Guanidinoacetate N-methyltransferase Activity Hydrogen Peroxide Metabolic Process Glyoxal Catabolic Process L-dopa Decarboxylase Activator Activity Guanine Deglycation Protein Deglycase Activity Glyoxalase (glycolic Acid-forming) Activity Glycolate Biosynthetic Process Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Detoxification Of Mercury Ion Negative Regulation Of Death-inducing Signaling Complex Assembly Cellular Response To Glyoxal Glyoxal Metabolic Process Positive Regulation Of L-dopa Biosynthetic Process Tyrosine 3-monooxygenase Activator Activity 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase Activity Creatine Biosynthetic Process TFIIF-class Transcription Factor Complex Binding Transcription Factor TFIIF Complex Cellular Response To Sorbitol Cellular Response To Hydrogen Peroxide Cellular Oxidant Detoxification Negative Regulation Of Protein K48-linked Deubiquitination Detection Of Oxidative Stress Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Dopamine Biosynthetic Process Creatine Metabolic Process Cellular Response To Anisomycin Response To Oxidative Stress Reactive Oxygen Species Metabolic Process Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Superoxide Dismutase Copper Chaperone Activity Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Glycolate Metabolic Process Detoxification Of Hydrogen Peroxide Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of TRAIL Production Mercury Ion Binding Linear Polyubiquitin Binding Response To Hydrogen Peroxide Response To Anisomycin Cellular Response To Reactive Oxygen Species Response To Sorbitol Cellular Detoxification Cellular Detoxification Of Methylglyoxal Methylglyoxal Catabolic Process To Lactate	Serine/threonine Protein Kinase Complex Type I Interferon-mediated Signaling Pathway Interferon-mediated Signaling Pathway Collateral Sprouting Response To External Biotic Stimulus Cell Surface Receptor Signaling Pathway Protein-containing Complex Regulation Of Reactive Oxygen Species Metabolic Process Dendritic Spine Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Learning Or Memory Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Dendrite Development Signal Transduction Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Epidermal Growth Factor Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Defense Response To Virus Positive Regulation Of Ubiquitin-specific Protease Activity Cognition Negative Regulation Of Signal Transduction Acetylcholine Receptor Activator Activity Developmental Growth Response To Interleukin-1 Plasma Membrane Bounded Cell Projection Organization Regulation Of MiRNA Transcription Negative Regulation Of Signaling Cellular Localization Lipoprotein Particle Regulation Of Programmed Cell Death Positive Regulation Of Protein Import Negative Regulation Of Cell Communication Nervous System Process ERBB Signaling Pathway Phospholipase D Activator Activity Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Neutrophil Degranulation Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Shc-EGFR Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Programmed Cell Death PTB Domain Binding Axon Collateral Sprouting In Absence Of Injury Regulation Of Protein Import