SENP8

Gene Name		SUMO/sentrin specific peptidase family member 8
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	NEDD8-specific Protease Activity
	Biological Process	Protein Deneddylation Proteolysis
Pathways
Drugs
Diseases
GWAS		Metabolite levels (HVA/MHPG ratio) ( 23319000)
Protein-protein Interactions		12 interactors: COPS2 CUL1 CUL2 CUL4A GPS1 NEDD8 PLA2G2A SMURF1 UBB USP15 USP21 USP28
Entrez ID		123228
HPRD ID		09784
Ensembl ID		ENSG00000166192
Uniprot IDs		A8K8D3 Q96LD8
PDB IDs		1XT9 2BKQ 2BKR
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Catabolic Process Protein Modification By Small Protein Removal Cellular Protein Modification Process Proteolysis Cellular Protein Metabolic Process Protein Modification By Small Protein Conjugation Apoptotic Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway Response To Transforming Growth Factor Beta Regulation Of Proteasomal Protein Catabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cullin Deneddylation Regulation Of Proteolysis Signal Transduction Protein Deneddylation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cell Cycle Signaling Regulation Of Metabolic Process Cell Communication Regulation Of Protein Metabolic Process Cellular Metabolic Process Histone Deubiquitination Cell Cycle Arrest Negative Regulation Of Cell Cycle Response To Stimulus Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Programmed Cell Death Cell Cycle Process
Tagcloud ?		attributed bca3 bind conversely crucial cullins deacetylase du145 link mcf7 modification nad necrosis nedd8 neddylated neddylation nfkappab p65 prolongs protease recruit reversed silencing sirt1 span substrates ubiquitin worms yeast