SCARA5 and KANK2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SCARA5	KANK2
Name		scavenger receptor class A member 5	KN motif and ankyrin repeat domains 2
Structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Cytoplasm Mitochondrion
	Molecular Function	Protein Binding Ferritin Receptor Activity	Protein Binding
	Biological Process	Monoatomic Ion Transport Iron Ion Transport Intracellular Iron Ion Homeostasis Endocytosis Cellular Response To Heat Iron Ion Transmembrane Transport Protein Homotrimerization	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Rho Protein Signal Transduction Negative Regulation Of Programmed Cell Death Negative Regulation Of Vitamin D Receptor Signaling Pathway Kidney Epithelium Development Podocyte Cell Migration Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Scavenging by Class A Receptors	None
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065 ) Age-related cognitive decline (executive function) (slope of z-scores) ( 30954325 ) Factor VIII levels ( 30586737 ) Lack of premeditation ( 30718321 ) Low vWF levels ( 26486471 ) Venous thromboembolism ( 31420334 ) vWF levels ( 30586737 )	Apolipoprotein B levels ( 32203549 ) Cholesterol, total ( 26780889 ) Coronary artery disease ( 29212778 ) HDL cholesterol ( 23505323 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Intraocular pressure ( 31959993 ) Low density lipoprotein cholesterol levels ( 32154731 32902719 ) Mean spheric corpuscular volume ( 32888494 ) Non-HDL cholesterol levels ( 32902719 ) Red cell distribution width ( 28957414 32888494 27863252 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Triglyceride levels ( 32203549 )
Interacting Genes		16 interacting genes: C1QL4 CMTM5 EHHADH EXOC8 FBXO7 KANK2 NTAQ1 P4HA3 PSMB1 RNF151 SLC35B4 SMARCD1 SNCA TMEM208 TSG101 WASHC3	187 interacting genes: ABI3 AEN ANKRD11 AP2B1 ARL14EP ASB15 BEND7 BIRC7 BLZF1 BORCS6 C2orf68 CADPS CAMK2G CAPN3 CARD10 CARD9 CBX8 CCDC33 CCDC57 CCDC88B CDC20B CDC5L CDKL3 CEACAM6 CEP55 CEP63 CEP70 CFAP68 CHCHD3 CHIC2 CINP COG6 CRX CSNK2A1 CUTC CWF19L2 CYTH4 DDIT4L DLGAP3 DPEP2NB DTX2 DYNLL1 EFHC2 EIF4E ELOA EXOSC8 FAM161A FAM90A1 FHL2 FHL3 FKBP6 GADD45GIP1 GATA1 GEMIN4 GKAP1 GMCL1 GMNN GOLGA2 GOLGA6A GOLGA6L9 GPANK1 GPKOW GPSM1 GRB10 HAND2 HOMER3 HSF2BP HSPB2 HSPB2-C11orf52 IHO1 IKZF3 IL16 KIF9 KIFAP3 KIFC3 KRT27 KRT31 KRT34 KRT40 KRT75 KRT86 KRTAP6-3 L3MBTL3 LBX1 LENG1 LHX1 LHX3 LMO1 LMO2 LMO3 LMO4 LZTS1 MAGEB4 MCCD1 MCRS1 MED19 MEOX1 MEOX2 MID2 MITD1 MKRN3 MOB1A MOB3C MORN3 MSS51 MTUS2 MYOZ3 NCOA1 NCOA5 NECAB2 NOS3 NRIP1 NUTM1 OIP5 PAX6 PCBD1 PDE9A PDLIM7 PFDN6 PIBF1 PLAGL2 PLEKHA2 PNKP PPP1CB PRDM14 PRDM6 PRKAR1B PRMT5 PRPF18 PRPF31 PRR5L PSEN1 PSMB4 PSTPIP1 RAB11FIP2 RALBP1 RBCK1 RHOH SCARA5 SCNM1 SERTAD3 SNAPIN SNW1 SORBS3 SRPK2 STAC SYT6 TAX1BP1 TEX11 TFIP11 TGM5 THAP1 THAP6 TIFA TLE5 TOP3B TRAF1 TRAF2 TRAF4 TRIB3 TRIM35 TRIM54 TSGA10 TSGA10IP TSPYL6 TXLNA UBAP2 UBC USHBP1 UTP14C VMAC VPS52 VWC2 WASF3 WASHC1 ZBTB42 ZFP57 ZMAT2 ZMYND12 ZNF212 ZNF414 ZNF512 ZNF648 ZNF774 ZNF784 ZNHIT1 ZRANB1
Entrez ID		286133	25959
HPRD ID		11356	12463
Ensembl ID		ENSG00000168079	ENSG00000197256
Uniprot IDs		Q6ZMJ2	Q63ZY3
PDB IDs		7C00	4HBD 5YBV 6TMD
GO Terms Enriched among Interactors		Exocytosis Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Secretion By Cell Membrane Fission Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Protein-N-terminal Glutamine Amidohydrolase Activity UDP-xylose Transmembrane Transport UDP-xylose Transmembrane Transporter Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Secretion Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Ubiquitin-dependent Endocytosis Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Vitamin D Receptor Signaling Pathway Vacuolar Protein Processing Protein-N-terminal Asparagine Amidohydrolase Activity	Protein Binding Identical Protein Binding Nucleus Structural Constituent Of Skin Epidermis