SCARA5 and C1QL4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SCARA5	C1QL4
Name		scavenger receptor class A member 5	complement C1q like 4
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Extracellular Region Collagen Trimer Extracellular Space
	Molecular Function	Protein Binding Ferritin Receptor Activity	Protein Binding Identical Protein Binding
	Biological Process	Monoatomic Ion Transport Iron Ion Transport Intracellular Iron Ion Homeostasis Endocytosis Cellular Response To Heat Iron Ion Transmembrane Transport Protein Homotrimerization	Negative Regulation Of Fat Cell Differentiation Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		Scavenging by Class A Receptors	None
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065 ) Age-related cognitive decline (executive function) (slope of z-scores) ( 30954325 ) Factor VIII levels ( 30586737 ) Lack of premeditation ( 30718321 ) Low vWF levels ( 26486471 ) Venous thromboembolism ( 31420334 ) vWF levels ( 30586737 )	No GWAS studies recorded
Interacting Genes		16 interacting genes: C1QL4 CMTM5 EHHADH EXOC8 FBXO7 KANK2 NTAQ1 P4HA3 PSMB1 RNF151 SLC35B4 SMARCD1 SNCA TMEM208 TSG101 WASHC3	19 interacting genes: CD53 CERS4 FATE1 FNDC9 GOLM1 GPR152 IL10RA LEUTX MFF RHCG SCARA5 SGTA SGTB SLC38A1 SSMEM1 TMEM179B TMPRSS2 TRHR UBQLN2
Entrez ID		286133	338761
HPRD ID		11356	17350
Ensembl ID		ENSG00000168079	ENSG00000186897
Uniprot IDs		Q6ZMJ2	A0A3B0INP7 Q86Z23
PDB IDs		7C00	Not available
GO Terms Enriched among Interactors		Exocytosis Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Secretion By Cell Membrane Fission Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Protein-N-terminal Glutamine Amidohydrolase Activity UDP-xylose Transmembrane Transport UDP-xylose Transmembrane Transporter Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Secretion Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Ubiquitin-dependent Endocytosis Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Vitamin D Receptor Signaling Pathway Vacuolar Protein Processing Protein-N-terminal Asparagine Amidohydrolase Activity	Membrane TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of ERAD Pathway Identical Protein Binding Regulation Of ERAD Pathway Establishment Of Protein Localization To Organelle Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Interleukin-10 Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Thyrotropin-releasing Hormone Receptor Activity Ferritin Receptor Activity Protein Targeting