SCARA5 and TMEM208

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SCARA5	TMEM208
Name		scavenger receptor class A member 5	transmembrane protein 208
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Vacuole Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Ferritin Receptor Activity	Protein Binding
	Biological Process	Monoatomic Ion Transport Iron Ion Transport Intracellular Iron Ion Homeostasis Endocytosis Cellular Response To Heat Iron Ion Transmembrane Transport Protein Homotrimerization	Vacuolar Protein Processing Autophagy
Pathways		Scavenging by Class A Receptors	None
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065 ) Age-related cognitive decline (executive function) (slope of z-scores) ( 30954325 ) Factor VIII levels ( 30586737 ) Lack of premeditation ( 30718321 ) Low vWF levels ( 26486471 ) Venous thromboembolism ( 31420334 ) vWF levels ( 30586737 )	No GWAS studies recorded
Interacting Genes		16 interacting genes: C1QL4 CMTM5 EHHADH EXOC8 FBXO7 KANK2 NTAQ1 P4HA3 PSMB1 RNF151 SLC35B4 SMARCD1 SNCA TMEM208 TSG101 WASHC3	23 interacting genes: C10orf67 CREB3L1 EBP FAM209A GPR152 GPRC5D KCNJ6 LMNA NDRG4 PGRMC2 REEP2 REEP4 RNF19B SCARA5 SCN3B SLC10A6 SLC30A8 SLC71A2 SLC7A8 SPG21 STOM TMEM31 TMX2
Entrez ID		286133	29100
HPRD ID		11356	13710
Ensembl ID		ENSG00000168079	ENSG00000168701
Uniprot IDs		Q6ZMJ2	J3KRY7 Q9BTX3
PDB IDs		7C00	Not available
GO Terms Enriched among Interactors		Exocytosis Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Secretion By Cell Membrane Fission Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Protein-N-terminal Glutamine Amidohydrolase Activity UDP-xylose Transmembrane Transport UDP-xylose Transmembrane Transporter Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Secretion Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Ubiquitin-dependent Endocytosis Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Vitamin D Receptor Signaling Pathway Vacuolar Protein Processing Protein-N-terminal Asparagine Amidohydrolase Activity	Membrane Monoatomic Cation Transport Metal Ion Transport Nuclear Envelope Organization Endoplasmic Reticulum Membrane Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization