TTYH2 and KDELR2

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TTYH2	KDELR2
Description		tweety family member 2	KDEL endoplasmic reticulum protein retention receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Chloride Channel Complex	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Membrane Transport Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Volume-sensitive Anion Channel Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Calcium Ion Binding Protein Binding Metal Ion Binding Volume-sensitive Chloride Channel Activity	KDEL Sequence Binding ER Retention Sequence Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport L-glutamate Transmembrane Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport	Protein Retention In ER Lumen Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport Maintenance Of Protein Localization In Endoplasmic Reticulum
Pathways		Stimuli-sensing channels	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Systolic blood pressure (cigarette smoking interaction) ( 26752167)	Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Irritable bowel syndrome ( 25248455) Lymphocyte percentage of white cells ( 27863252 32888494) Mean platelet volume ( 27863252 32888494) Monocyte count ( 27863252 29403010 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Red cell distribution width ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		15 interacting genes: CCND2 CDKN2B COPB1 ERBB2 FGFR4 GPR37 GRM1 IGF1R IKBKG KAT2A KDELR2 NEDD4 NF2 PDGFRA TRARG1	22 interacting genes: AKT1 BECN1 CCND2 CD44 CDK4 CDK6 CDKN2B EPHA2 ERBB2 FGFR4 GRM1 IGF1R KAT2A LATS2 MAP2K3 MET MYC NF2 PDGFRA RASSF1 STK11 TTYH2
Entrez ID		94015	11014
HPRD ID		16394	06598
Ensembl ID		ENSG00000141540	ENSG00000136240
Uniprot IDs		B4DKD1 Q9BSA4	P33947
PDB IDs		7P54 7P5M
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Receptor Complex Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Tyrosine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction COPI-coated Vesicle Membrane Transport Vesicle Ubiquitin Ligase Complex Protein Autophosphorylation Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Regulation Of Cell Population Proliferation Phosphorylation Long-term Memory Neuromuscular Junction Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Signal Transduction Protein Kinase Activity Peptidyl-lysine Glutarylation Histone Glutaryltransferase Activity Histone Succinyltransferase Activity Peptide Glutaryltransferase Activity G Protein-coupled Receptor Homodimeric Complex G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Formation Of Structure Involved In A Symbiotic Process Platelet-derived Growth Factor Alpha-receptor Activity Plasma Membrane Protein Modification Process ERBB3:ERBB2 Complex Kinase Activity Histone H3K9 Acetyltransferase Activity Prosaposin Receptor Activity Dendriole Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Dimeric Complex Channel Inhibitor Activity Odontogenesis Of Dentin-containing Tooth Platelet-derived Growth Factor Receptor-alpha Signaling Pathway	Protein Kinase Activity Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Signal Transduction Response To Growth Factor Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Transferase Activity Regulation Of Signal Transduction ATP Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Receptor Complex Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization Protein Phosphorylation Regulation Of Catalytic Activity Nucleotide Binding Regulation Of Epithelial Cell Proliferation Phosphorylation Protein Autophosphorylation Positive Regulation Of Cellular Component Organization Peptidyl-tyrosine Phosphorylation Positive Regulation Of Fibroblast Proliferation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Mitotic Cell Cycle Phase Transition Positive Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process Cell Cycle Phase Transition Positive Regulation Of Catalytic Activity Negative Regulation Of Intracellular Signal Transduction Animal Organ Development Intracellular Signal Transduction Protein Serine Kinase Activity Cyclin D2-CDK4 Complex Regulation Of Programmed Cell Death Regulation Of Fibroblast Proliferation
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