TTYH2 and CCND2

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TTYH2	CCND2
Description		tweety family member 2	cyclin D2
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Chloride Channel Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Membrane Nuclear Membrane Cyclin D2-CDK4 Complex
	Molecular Function	Volume-sensitive Anion Channel Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Calcium Ion Binding Protein Binding Metal Ion Binding Volume-sensitive Chloride Channel Activity	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Monoatomic Ion Transport Chloride Transport L-glutamate Transmembrane Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport	G1/S Transition Of Mitotic Cell Cycle Long-term Memory Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Apoptotic Process Cell Division Regulation Of Cell Cycle Cellular Response To X-ray Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Stimuli-sensing channels	Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity
Drugs
Diseases			Testicular cancer
GWAS		Systolic blood pressure (cigarette smoking interaction) ( 26752167)	Alanine aminotransferase levels ( 34315874) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Blood glucose levels ( 31928498) Brown vs. black hair color ( 30531825) Colorectal cancer ( 24836286 31826910 26151821 30529582 23266556 23263487) Colorectal cancer or advanced adenoma ( 30510241) Glucocorticoid-induced osteonecrosis ( 26265699) Height ( 28270201 28552196) Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 19107115 23377640) Mean corpuscular hemoglobin ( 28017375) Mean corpuscular volume ( 28017375) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 27841878 30578418) QT interval (drug interaction) ( 23459443) Red blood cell count ( 20139978 28017375) Red blood cell traits ( 23222517) Smoking behaviour (cigarettes smoked per day) ( 30679032) Triglyceride levels ( 31928498 32154731 32203549) Type 2 diabetes ( 30297969 31118516 30054458 29358691 28869590 32499647 22885922) Waist circumference ( 31928498)
Interacting Genes		15 interacting genes: CCND2 CDKN2B COPB1 ERBB2 FGFR4 GPR37 GRM1 IGF1R IKBKG KAT2A KDELR2 NEDD4 NF2 PDGFRA TRARG1	64 interacting genes: ABCB5 ABL1 ADRB2 AKAP8 AKT1 ARAF ARNT AURKA BECN1 CALM1 CALM2 CALM3 CBLC CCNE1 CD44 CDK4 CDK5 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C DMTF1 EPHA2 ERBB2 FBXL2 FGFR4 FZR1 GLIS2 GRM1 H1-1 HGF HIF1A KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MET NF2 NPDC1 PCGF2 PDGFRA PIK3CA PSMD10 PTEN RAF1 RASSF1 RB1 RELA RUNX1 SERTAD1 STK11 TEAD2 TERT TEX11 TNFRSF1A TSC1 TTYH2
Entrez ID		94015	894
HPRD ID		16394	00451
Ensembl ID		ENSG00000141540	ENSG00000118971
Uniprot IDs		B4DKD1 Q9BSA4	P30279
PDB IDs		7P54 7P5M	6EI2
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Receptor Complex Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Tyrosine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction COPI-coated Vesicle Membrane Transport Vesicle Ubiquitin Ligase Complex Protein Autophosphorylation Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Regulation Of Cell Population Proliferation Phosphorylation Long-term Memory Neuromuscular Junction Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Signal Transduction Protein Kinase Activity Peptidyl-lysine Glutarylation Histone Glutaryltransferase Activity Histone Succinyltransferase Activity Peptide Glutaryltransferase Activity G Protein-coupled Receptor Homodimeric Complex G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Formation Of Structure Involved In A Symbiotic Process Platelet-derived Growth Factor Alpha-receptor Activity Plasma Membrane Protein Modification Process ERBB3:ERBB2 Complex Kinase Activity Histone H3K9 Acetyltransferase Activity Prosaposin Receptor Activity Dendriole Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Dimeric Complex Channel Inhibitor Activity Odontogenesis Of Dentin-containing Tooth Platelet-derived Growth Factor Receptor-alpha Signaling Pathway	Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Animal Organ Development Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Signal Transduction Protein Kinase Activity Regulation Of Cell Cycle Process Regulation Of Cell Population Proliferation Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Kinase Binding Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Developmental Process Positive Regulation Of Signal Transduction Protein Serine Kinase Activity Regulation Of Growth Regulation Of Apoptotic Process Cell Cycle Phase Transition Negative Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Cellular Senescence Regulation Of Catalytic Activity Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Developmental Process Apoptotic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Programmed Cell Death Cell Death Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Cell Differentiation Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Cell Differentiation
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