NKIRAS1 and BMPR1B

Number of citations: 0 (PubMedID 15761153)
Data Source: HPRD (in vivo)

		NKIRAS1	BMPR1B
Name		NFKB inhibitor interacting Ras like 1	bone morphogenetic protein receptor type 1B
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol	Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex
	Molecular Function	Nucleotide Binding GTPase Activity GTP Binding GTPase Activating Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Transferase Activity BMP Binding SMAD Binding Metal Ion Binding BMP Receptor Activity
	Biological Process	Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Ral Protein Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Surfactant Homeostasis Lung Alveolus Development	Cartilage Condensation Ovarian Cumulus Expansion Osteoblast Differentiation Eye Development Chondrocyte Differentiation Chondrocyte Development Inflammatory Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Central Nervous System Neuron Differentiation Cell Differentiation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Positive Regulation Of Chondrocyte Differentiation Ovulation Cycle Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Retina Development In Camera-type Eye Bone Development Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation
Pathways		RIP-mediated NFkB activation via ZBP1 TAK1-dependent IKK and NF-kappa-B activation TRAF6 mediated NF-kB activation	Signaling by BMP
Drugs		None	Fostamatinib
Diseases		None	Acromesomelic dysplasia with genital anomalies Brachydactyly, including: type A; type B; type D; type E
GWAS		Acne (severe) ( 24927181 ) Extremely high intelligence ( 29520040 ) General cognitive ability ( 29844566 ) Intake of total sugars ( 31005972 ) Intelligence (MTAG) ( 29326435 )	Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Attention deficit hyperactivity disorder ( 20732626 ) Colorectal cancer or advanced adenoma ( 30510241 ) Coronary artery disease ( 29212778 33020668 ) Diverticular disease ( 30177863 ) Haemorrhoidal disease ( 33888516 ) Heel bone mineral density ( 30598549 ) Hen's egg allergy ( 29051540 ) Maximum stenosis ( 32469969 ) Opioid dependence (time to event) ( 34124712 ) Polycystic ovary syndrome (reproductive subtype) ( 32574161 ) Prepulse inhibition of the startle response ( 31596458 ) Schizophrenia ( 30470734 ) Sum of carotid plaque area ( 32469969 ) Sum of stenosis ( 32469969 ) Systolic blood pressure ( 30578418 30224653 ) Waist-hip ratio ( 28552196 )
Interacting Genes		8 interacting genes: ACVR1 APP BMPR1B NFKBIA NFKBIB SMURF2 TGFBR1 XRCC2	64 interacting genes: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OTUB1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1
Entrez ID		28512	658
HPRD ID		06841	04457
Ensembl ID		ENSG00000197885	ENSG00000138696
Uniprot IDs		Q9NYS0	A8KAE3 O00238
PDB IDs		Not available	3MDY
GO Terms Enriched among Interactors		Transforming Growth Factor Beta Receptor Activity, Type I SMAD Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus BMP Receptor Activity Activin Receptor Complex Positive Regulation Of Developmental Process Activin Receptor Activity, Type I Regionalization Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Response To Growth Factor Regulation Of Developmental Process Activin Binding Regulation Of Cell Differentiation Pattern Specification Process Regulation Of Apoptotic Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Process Pharyngeal System Development Positive Regulation Of RNA Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Signal Transduction Transforming Growth Factor Beta Binding Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Inflammatory Response Regulation Of Cell Communication Positive Regulation Of Cell Migration Activin Receptor Signaling Pathway Regulation Of RNA Metabolic Process Cellular Response To BMP Stimulus Positive Regulation Of Cell Motility Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signaling Receptor Complex Positive Regulation Of Locomotion Membrane Raft Reproductive Process Defense Response Regulation Of Nucleobase-containing Compound Metabolic Process Ventricular Septum Morphogenesis In Utero Embryonic Development	Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cartilage Development Response To Growth Factor Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cartilage Development Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Cellular Response To BMP Stimulus GTPase Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling GTP Binding Positive Regulation Of Bone Mineralization Cardiac Septum Morphogenesis Ubiquitin Protein Ligase Binding Regulation Of Ossification Nucleotide Binding Positive Regulation Of Biomineral Tissue Development Regulation Of Chondrocyte Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Regulation Of Osteoblast Differentiation Mesenchyme Development BMP Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Growth Factor Activity Negative Regulation Of Signal Transduction Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Locomotion Intracellular Signal Transduction Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Signaling Negative Regulation Of Cell Communication Post-translational Protein Modification Regulation Of Cell Migration