NKIRAS1 and XRCC2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		NKIRAS1	XRCC2
Name		NFKB inhibitor interacting Ras like 1	X-ray repair cross complementing 2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol	Nucleus Nucleoplasm Replication Fork Cytoplasm Centrosome Cytoskeleton Rad51B-Rad51C-Rad51D-XRCC2 Complex
	Molecular Function	Nucleotide Binding GTPase Activity GTP Binding GTPase Activating Protein Binding	Four-way Junction DNA Binding DNA Binding Protein Binding ATP Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Ral Protein Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Surfactant Homeostasis Lung Alveolus Development	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis DNA Repair DNA Recombination DNA Damage Response Centrosome Cycle Response To X-ray Response To Gamma Radiation Neurogenesis Multicellular Organism Growth DNA Strand Invasion Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neurogenesis Meiotic Cell Cycle Regulation Of Fibroblast Apoptotic Process
Pathways		RIP-mediated NFkB activation via ZBP1 TAK1-dependent IKK and NF-kappa-B activation TRAF6 mediated NF-kB activation	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2
GWAS		Acne (severe) ( 24927181 ) Extremely high intelligence ( 29520040 ) General cognitive ability ( 29844566 ) Intake of total sugars ( 31005972 ) Intelligence (MTAG) ( 29326435 )	Diabetic kidney disease ( 26305897 ) Mean platelet volume ( 27863252 32888494 ) Palmitic acid (16:0) levels ( 23362303 )
Interacting Genes		8 interacting genes: ACVR1 APP BMPR1B NFKBIA NFKBIB SMURF2 TGFBR1 XRCC2	5 interacting genes: MEOX2 NKIRAS1 RAD51 RAD51D WFDC1
Entrez ID		28512	7516
HPRD ID		06841	02656
Ensembl ID		ENSG00000197885	ENSG00000196584
Uniprot IDs		Q9NYS0	A0A384MEK2 O43543
PDB IDs		Not available	8FAZ 8GBJ 8OUY 8OUZ
GO Terms Enriched among Interactors		Transforming Growth Factor Beta Receptor Activity, Type I SMAD Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus BMP Receptor Activity Activin Receptor Complex Positive Regulation Of Developmental Process Activin Receptor Activity, Type I Regionalization Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Response To Growth Factor Regulation Of Developmental Process Activin Binding Regulation Of Cell Differentiation Pattern Specification Process Regulation Of Apoptotic Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Process Pharyngeal System Development Positive Regulation Of RNA Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Signal Transduction Transforming Growth Factor Beta Binding Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Inflammatory Response Regulation Of Cell Communication Positive Regulation Of Cell Migration Activin Receptor Signaling Pathway Regulation Of RNA Metabolic Process Cellular Response To BMP Stimulus Positive Regulation Of Cell Motility Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signaling Receptor Complex Positive Regulation Of Locomotion Membrane Raft Reproductive Process Defense Response Regulation Of Nucleobase-containing Compound Metabolic Process Ventricular Septum Morphogenesis In Utero Embryonic Development	DNA Strand Invasion ATP-dependent DNA Damage Sensor Activity Telomere Maintenance Via Recombination Mitotic Recombination Reciprocal Meiotic Recombination ATP-dependent Activity, Acting On DNA Homologous Recombination Interstrand Cross-link Repair Response To Glucoside Telomere Maintenance Mitotic Recombination-dependent Replication Fork Processing Single-stranded DNA Binding Double-strand Break Repair Via Homologous Recombination DNA Strand Exchange Activity Telomere Organization Presynaptic Intermediate Filament Cytoskeleton Recombinational Repair Cellular Response To Cisplatin Chromosome, Telomeric Region Rad51B-Rad51C-Rad51D-XRCC2 Complex Ral Protein Signal Transduction Somite Specification DNA Recombinase Assembly Cellular Response To Camptothecin Nuclear Ubiquitin Ligase Complex Double-strand Break Repair Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Response To Cisplatin DNA Recombination Response To Glycoside Double-strand Break Repair Involved In Meiotic Recombination Cellular Response To Hydroxyurea GTPase Activating Protein Binding Response To Hydroxyurea Chromosome Organization Lateral Element Segment Specification Somite Development Four-way Junction DNA Binding Single-stranded DNA Helicase Activity Surfactant Homeostasis DNA Polymerase Binding Regulation Of DNA Damage Checkpoint Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Nucleotide Binding Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome Response To X-ray DNA Repair Cellular Response To Gamma Radiation