TSPAN12 and GPR25

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSPAN12	GPR25
Description		tetraspanin 12	G protein-coupled receptor 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding Wnt Receptor Activity	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Angiogenesis Cell Surface Receptor Signaling Pathway Retina Layer Formation Maintenance Of Blood-brain Barrier Regulation Of Angiogenesis Norrin Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways			G alpha (s) signalling events
Drugs
Diseases		Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)
GWAS		Bitter alcoholic beverage consumption ( 31046077) Heel bone mineral density ( 30598549)	Ankylosing spondylitis ( 23749187) Autoimmune thyroid disease ( 32581359) Refractive error ( 32231278)
Interacting Genes		21 interacting genes: CDS2 CTXN3 CXCL16 CYBC1 EMP3 GPR25 GPR37L1 IGFBP5 MARCHF2 MGST3 NINJ2 PMP22 RFT1 RNF152 STX8 TEX264 TFCP2 TMEM140 TMEM147 TMEM182 TMEM218	32 interacting genes: AQP6 ATP6V0C ATP6V0E1 BEST2 CNIH4 CREB3L1 CREB3L3 FATE1 GGT7 GJB1 IKBIP KASH5 LDLRAD1 LMNA MAP3K7 MMGT1 NAALADL2 PNMA1 RETN RHCG SHISAL1 SLC16A7 SLC35E3 SLC61A1 SLCO4A1 STOM TMEM237 TMEM248 TMEM52B TPRA1 TSPAN12 VAPB
Entrez ID		23554	2848
HPRD ID		15509	03707
Ensembl ID		ENSG00000106025	ENSG00000170128
Uniprot IDs		O95859	O00155
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Bleb Assembly Endoplasmic Reticulum Membrane Endoplasmic Reticulum	Membrane Carbon Dioxide Transmembrane Transporter Activity Transmembrane Transport Carbon Dioxide Transmembrane Transport Ammonium Transmembrane Transport Ammonium Channel Activity Proton-transporting V-type ATPase, V0 Domain Host-mediated Activation Of Viral Genome Replication Endoplasmic Reticulum Membrane Host-mediated Perturbation Of Viral Genome Replication Carbon Dioxide Transport Protein Binding Proton-transporting V-type ATPase Complex Response To Unfolded Protein Intracellular Monoatomic Ion Homeostasis Proton-transporting ATPase Activity, Rotational Mechanism Regulation Of PH One-carbon Compound Transport Basolateral Plasma Membrane Monoatomic Ion Transport
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