TSPAN12 and RFT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSPAN12	RFT1
Description		tetraspanin 12	RFT1 glycolipid translocator homolog
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Wnt Receptor Activity	Protein Binding Glycolipid Floppase Activity
	Biological Process	Angiogenesis Cell Surface Receptor Signaling Pathway Retina Layer Formation Maintenance Of Blood-brain Barrier Regulation Of Angiogenesis Norrin Signaling Pathway	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Glycolipid Translocation
Pathways			Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective RFT1 causes CDG-1n
Drugs
Diseases		Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)	Congenital disorders of glycosylation (CDG) type I
GWAS		Bitter alcoholic beverage consumption ( 31046077) Heel bone mineral density ( 30598549)	A body shape index ( 34021172) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Crohn's disease ( 28067908) Diastolic blood pressure ( 32902719) Feeling worry ( 29500382) Height ( 23563607 31562340) High density lipoprotein cholesterol levels ( 31928498) Hip circumference adjusted for BMI ( 25673412 34021172) Immune reponse to smallpox (secreted IL-2) ( 22610502) Schizophrenia ( 23974872) Serum uric acid levels ( 29403010 30993211) Type 2 diabetes ( 30297969) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		21 interacting genes: CDS2 CTXN3 CXCL16 CYBC1 EMP3 GPR25 GPR37L1 IGFBP5 MARCHF2 MGST3 NINJ2 PMP22 RFT1 RNF152 STX8 TEX264 TFCP2 TMEM140 TMEM147 TMEM182 TMEM218	12 interacting genes: AQP6 BEST2 CNR2 CREB3L1 ERGIC3 MUC1 NEDD4 PSMA3 RNF144A TMX2 TNS2 TSPAN12
Entrez ID		23554	91869
HPRD ID		15509	15239
Ensembl ID		ENSG00000106025	ENSG00000163933
Uniprot IDs		O95859	Q96AA3
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Bleb Assembly Endoplasmic Reticulum Membrane Endoplasmic Reticulum
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