EMC10 and SMO

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		EMC10	SMO
Description		ER membrane protein complex subunit 10	smoothened, frizzled class receptor
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GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane EMC Complex	Cytoplasm Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Centriole Plasma Membrane Caveola Cilium Membrane Dendrite Endocytic Vesicle Membrane Cell Projection Ciliary Membrane Extracellular Exosome Ciliary Tip 9+0 Non-motile Cilium Plasma Membrane Bounded Cell Projection
	Molecular Function	Membrane Insertase Activity	CAMP-dependent Protein Kinase Inhibitor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Patched Binding Protein Binding Oxysterol Binding Protein Kinase A Catalytic Subunit Binding Protein Sequestering Activity
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Migration Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Positive Regulation Of Angiogenesis Tail-anchored Membrane Protein Insertion Into ER Membrane	Negative Regulation Of Transcription By RNA Polymerase II Ossification Vasculogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Neural Crest Cell Migration Negative Regulation Of Protein Phosphorylation Hair Follicle Development Heart Looping Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Heart Morphogenesis Determination Of Left/right Asymmetry In Lateral Mesoderm Type B Pancreatic Cell Development Protein Import Into Nucleus Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Smoothened Signaling Pathway Determination Of Left/right Symmetry Ventral Midline Determination Pattern Specification Process Neuroblast Proliferation Central Nervous System Development Midgut Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Tissue Development Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Spinal Cord Dorsal/ventral Patterning Dentate Gyrus Development Cerebellar Cortex Morphogenesis Thalamus Development Dorsal/ventral Neural Tube Patterning Central Nervous System Neuron Differentiation Cerebral Cortex Development Positive Regulation Of Cell Migration Epithelial Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Astrocyte Activation Cell Development Digestive Tract Development Embryonic Organ Development Developmental Growth Skeletal Muscle Fiber Development Smooth Muscle Tissue Development Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Protein Stabilization Myoblast Migration Negative Regulation Of Hair Follicle Development Contact Inhibition Atrial Septum Morphogenesis Mammary Gland Epithelial Cell Differentiation Epithelial-mesenchymal Cell Signaling Somite Development Pancreas Morphogenesis Left/right Axis Specification Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Commissural Neuron Axon Guidance Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Response To Inositol Regulation Of Somatic Stem Cell Population Maintenance Regulation Of Heart Morphogenesis
Pathways			Class B/2 (Secretin family receptors) Hedgehog 'off' state BBSome-mediated cargo-targeting to cilium Hedgehog 'on' state Activation of SMO Activation of SMO
Drugs			Fluocinonide Halcinonide Vismodegib Sonidegib Glasdegib
Diseases			Basal cell carcinoma
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325)	Osteoarthritis (hip) ( 30374069)
Interacting Genes		3 interacting genes: CCR2 OXTR SMO	28 interacting genes: ARLN ARV1 C18orf32 EMC10 FKBP8 GABARAPL2 GABBR1 HMGN4 HMOX1 HMOX2 ITGB1BP1 JPH3 LEPROT NDFIP1 NEDD4 NGEF NIPA1 PLPP7 PTCH1 PTCH2 RPN2 S1PR5 SLC41A3 SSPN TIMMDC1 TMCC2 TSPAN7 WLS
Entrez ID		284361	6608
HPRD ID		14153	03294
Ensembl ID		ENSG00000161671	ENSG00000128602
Uniprot IDs		Q5UCC4	Q99835
PDB IDs		6WW7 6Z3W 7ADO 7ADP 8EOI 8J0N 8J0O 8S9S 9C7V	4JKV 4N4W 4O9R 4QIM 4QIN 5L7D 5L7I 5V56 5V57 6OT0 6XBJ 6XBK 6XBL 6XBM 7ZI0
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity Homeostasis Of Number Of Cells Within A Tissue Oxytocin Receptor Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Ventral Midline Determination Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Regulation Of Cold-induced Thermogenesis Tissue Homeostasis Anatomical Structure Homeostasis Homeostasis Of Number Of Cells Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Contact Inhibition Pancreas Morphogenesis Regulation Of Thymocyte Migration Regulation Of Immune Complex Clearance By Monocytes And Macrophages Detection Of Cell Density Response To Inositol CCR2 Chemokine Receptor Binding Positive Regulation Of T Cell Extravasation Maternal Process Involved In Parturition Regulation Of Systemic Arterial Blood Pressure By Vasopressin Cerebellar Cortex Morphogenesis Epithelial-mesenchymal Cell Signaling Negative Regulation Of Hair Follicle Development Positive Regulation Of Monocyte Extravasation Monocyte Extravasation Positive Regulation Of Multicellular Organismal Process Neutrophil Clearance Vasopressin Receptor Activity Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Spinal Cord Dorsal/ventral Patterning Midgut Development Patched Binding Cell Surface Receptor Signaling Pathway Determination Of Left/right Asymmetry In Lateral Mesoderm Forebrain Morphogenesis Regulation Of Heart Morphogenesis CAMP-dependent Protein Kinase Inhibitor Activity 9+0 Non-motile Cilium	Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Heme Oxidation Heme Oxygenase (decyclizing) Activity Hedgehog Family Protein Binding Hedgehog Receptor Activity Epidermal Cell Fate Specification Smoothened Binding Heme Catabolic Process Porphyrin-containing Compound Catabolic Process Dorsal/ventral Neural Tube Patterning Magnesium Ion Transmembrane Transporter Activity Magnesium Ion Transmembrane Transport Cell Fate Specification Magnesium Ion Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction
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