CLDN19 and LRRC25

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN19	LRRC25
Description		claudin 19	leucine rich repeat containing 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Paranodal Junction Schmidt-Lanterman Incisure Apical Junction Complex Perinuclear Region Of Cytoplasm Tight Junction Anchoring Junction Mesaxon	Cytoplasm Endoplasmic Reticulum Cytosol Microtubule Cytoskeleton Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding Cell-cell Adhesion Mediator Activity Paracellular Tight Junction Channel Activity	Protein Binding
	Biological Process	Retinal Pigment Epithelium Development Cell Adhesion Visual Perception Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Neuronal Action Potential Propagation Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cell Junction Assembly Apical Junction Assembly Renal Absorption Bicellular Tight Junction Assembly Tight Junction Organization Regulation Of Transepithelial Transport Paracellular Transport
Pathways		Tight junction interactions
Drugs
Diseases
GWAS			Body size at age 10 ( 32376654) Hyperemesis gravidarum ( 29563502) Monocyte percentage of white cells ( 27863252 32888494) Severity of nausea and vomiting of pregnancy ( 29563502) Systemic lupus erythematosus ( 28714469 33536424) White blood cell count ( 32888494)
Interacting Genes		63 interacting genes: AQP6 AQP9 BCL2L13 BIK BSCL2 BTN2A1 CD200R1 CD53 CD74 CLEC14A CLEC2D CLRN1 CREB3 CXCR3 CYSRT1 ERGIC3 FAM209A FCGR1A FCGRT FKBP7 FNDC9 GGT7 GJA8 GORAB GPR161 GPX8 HSD17B13 ICAM3 IFNGR2 IL3RA KEL KIR2DL3 KRT31 KRT34 LAPTM5 LRRC25 LRRC4C MFF MS4A14 MS4A4A MUC1 PDZK1IP1 PKD2L1 PLEKHB2 PVR SAR1A SCARB2 SGPL1 SLAMF6 SLC10A1 SLC35H1 SPACA1 SRPK2 STOM STOML3 SUSD3 SYNE4 TM4SF18 TMEM106C TMEM248 TMEM52B TMEM80 TNFSF14	38 interacting genes: ACD AGPAT4 ANKRD46 APOL3 ATP6V0C BMP10 BRICD5 C3orf52 CD72 CLDN19 CLEC1A CLN6 CLRN2 CNIH3 CXCL9 DEFB121 DNAJC30 EDDM3B FAM3C FATE1 FPR2 GPRC5D LHFPL5 MAL OPRM1 PKMYT1 PNLIPRP1 SEC22A SEC61G SMCO4 SPNS3 TMEM120A TMEM201 TNF TRAF3IP3 TSPAN4 VAMP5 YIPF6
Entrez ID		149461	126364
HPRD ID		10834	09597
Ensembl ID		ENSG00000164007	ENSG00000175489
Uniprot IDs		Q8N6F1	Q8N386
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding External Side Of Plasma Membrane Plasma Membrane	Membrane Detection Of Mechanical Stimulus Involved In Sensory Perception
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