CLDN19 and CD200R1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN19	CD200R1
Description		claudin 19	CD200 receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Paranodal Junction Schmidt-Lanterman Incisure Apical Junction Complex Perinuclear Region Of Cytoplasm Tight Junction Anchoring Junction Mesaxon	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding Cell-cell Adhesion Mediator Activity Paracellular Tight Junction Channel Activity	Protein Binding Immunoglobulin Receptor Activity Signaling Receptor Activity Glycosylated Region Protein Binding
	Biological Process	Retinal Pigment Epithelium Development Cell Adhesion Visual Perception Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Neuronal Action Potential Propagation Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cell Junction Assembly Apical Junction Assembly Renal Absorption Bicellular Tight Junction Assembly Tight Junction Organization Regulation Of Transepithelial Transport Paracellular Transport	Signal Transduction Negative Regulation Of Interleukin-6 Production Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Fc Receptor Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Macrophage Migration Negative Regulation Of T Cell Migration
Pathways		Tight junction interactions	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS			Asthma ( 32296059) Blood protein levels ( 30072576) Economic and political preferences ( 22566634) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neurological blood protein biomarker levels ( 31320639) Rheumatoid arthritis ( 28118524) Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) ( 28118524) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		63 interacting genes: AQP6 AQP9 BCL2L13 BIK BSCL2 BTN2A1 CD200R1 CD53 CD74 CLEC14A CLEC2D CLRN1 CREB3 CXCR3 CYSRT1 ERGIC3 FAM209A FCGR1A FCGRT FKBP7 FNDC9 GGT7 GJA8 GORAB GPR161 GPX8 HSD17B13 ICAM3 IFNGR2 IL3RA KEL KIR2DL3 KRT31 KRT34 LAPTM5 LRRC25 LRRC4C MFF MS4A14 MS4A4A MUC1 PDZK1IP1 PKD2L1 PLEKHB2 PVR SAR1A SCARB2 SGPL1 SLAMF6 SLC10A1 SLC35H1 SPACA1 SRPK2 STOM STOML3 SUSD3 SYNE4 TM4SF18 TMEM106C TMEM248 TMEM52B TMEM80 TNFSF14	9 interacting genes: ADIPOQ CD200 CLDN19 ERMP1 GALNT15 NINJ1 PTCH1 SFTPC SGTB
Entrez ID		149461	131450
HPRD ID		10834	09609
Ensembl ID		ENSG00000164007	ENSG00000163606
Uniprot IDs		Q8N6F1	Q8TD46
PDB IDs			9GWT
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding External Side Of Plasma Membrane Plasma Membrane	Negative Regulation Of Cell Population Proliferation Cell-cell Adhesion Mediator Activity Negative Regulation Of Cell Migration Heterotypic Cell-cell Adhesion Ferroptosis Neural Plate Axis Specification Positive Regulation Of Cholesterol Efflux Regulation Of Cholesterol Transport Regulation Of Cholesterol Efflux Positive Regulation Of Cholesterol Transport Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Inflammatory Response Response To Chlorate Positive Regulation Of Lipid Transport Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Detection Of Oxidative Stress TRC Complex Mesaxon Regulation Of Cell Motility Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Locomotion Glycosylated Region Protein Binding Hedgehog Family Protein Binding Hedgehog Receptor Activity Response To Linoleic Acid Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Cholesterol Import Cell-cell Adhesion Protein Binding Involved In Heterotypic Cell-cell Adhesion Negative Regulation Of Protein Transport Regeneration Membrane Destabilizing Activity Epidermal Cell Fate Specification Smoothened Binding Localization Within Membrane Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Receptor Binding Regulation Of Glycogen (starch) Synthase Activity Regulation Of Transepithelial Transport Negative Regulation Of Establishment Of Protein Localization Regulation Of Lipid Transport Regulation Of Mononuclear Cell Migration Negative Regulation Of Secretion By Cell Regulation Of Cholesterol Import
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